US4847071A
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US
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Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent
Assignee: Procter and Gamble Co
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Filing: 1987-10-22
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Granted: 1989-07-11
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Expires: 2007-10-22
Abstract
Abstract Disclosed are pharmaceutical compositions comprising tocopherol sorbate and an anti-inflammatory agent which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of tocopherol sorbate, an anti-inflammatory agent, and a sunscreen are also disclosed. Also disclosed is a method for using these compositions topically to prevent damage to skin caused by acute or chronic UV exposure.
Inventors
- 👤 Donald L. Bissett
- 👤 Rodney D. Bush
- 👤 Ranjit Chatterjee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 14:04
CPC Classifications
A; A61; A61Q; A61Q17/00; A61Q17/04; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/445; A61K8/49; A61K8/4973; A61K8/498; A61K8/67; A61K8/678; A61K8/72; A61K8/84; A61K8/89; A61K8/92; A61K8/922; A61P; A61P29/00; A61P3/00; A61P3/02; A61Q1/00; A61Q1/02; A61Q1/04; A61Q1/06; A61Q19/00; A61Q19/10; A61Q5/00; A61Q5/02; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
135 words
A photoprotective composition useful for topical application comprising: (a) a safe and photoprotectively effective amount of a radical scavenging compound selected from the group consisting of tocopherol and tocopherol esters selected from acetate, succinate, propionate, oleate, orotate, benzoate, p-aminobenzoate, p-nitrobenzoate, linoleate, nicotinate, 2-ethylhexanoate and sorbate, and mixtures thereof; (b) a safe and photoprotectively effective amount of an anti-inflammatory agent selected from the group consisting of a steroidal anti-inflammatory agent; a non-steroidal anti-inflammatory agent selected from the group consisting of the oxicams, the salicylates, the acetic acid derivatives, the fenamates, the propionic acid derivatives, the pyrazoles, the 2,6-di-tert-butyl phenol derivatives, and the 2-naphtyl-containing ester compounds; and a natural anti-inflammatory agent selected from the group consisting of candelilla wax, alpha bisabolol, aloe vera, Manjistha, and Guggal; and (c) a safe and effective amount of a topical carrier.
Claim 2
Dependent Claim
135 words
A photoprotective composition useful for topical application comprising: (a) a safe and photoprotectively effective amount of a radical scavenging compound selected from the group consisting of tocopherol and tocopherol esters selected from acetate, succinate, propionate, oleate, orotate, benzoate, p-aminobenzoate, p-nitrobenzoate, linoleate, nicotinate, 2-ethylhexanoate and sorbate, and mixtures thereof; (b) a safe and photoprotectively effective amount of an anti-inflammatory agent selected from the group consisting of a steroidal anti-inflammatory agent; a non-steroidal anti-inflammatory agent selected from the group consisting of the oxicams, the salicylates, the acetic acid derivatives, the fenamates, the propionic acid derivatives, the pyrazoles, the 2,6-di-tert-butyl phenol derivatives, and the 2-naphtyl-containing ester compounds; and a natural anti-inflammatory agent selected from the group consisting of candelilla wax, alpha bisabolol, aloe vera, Manjistha, and Guggal; and (c) a safe and effective amount of a topical carrier.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein the radical scavenging compound is tocopherol sorbate.
Claim 4
Dependent Claim
16 words
The composition of claim 2 which comprises from about 1% to about 10% of tocopherol sorbate.
Claim 5
Dependent Claim
16 words
The composition of claim 3 which comprises from about 1% to about 5% of tocopherol sorbate.
Claim 6
Dependent Claim
17 words
The composition of claim 3 which comprises from about 0.2% to about 5% of the anti-inflammatory agent.
Claim 7
Dependent Claim
17 words
The composition of claim 5 which comprises from about 0.5% to about 2% of the anti-inflammatory agent.
Claim 8
Dependent Claim
37 words
The composition of claim 5 wherein the anti-inflammatory agent is selected from the group consisting of hydrocortisone, ibuprofen, naproxen, flufenamic acid, mefenamic acid, meclofenamic acid, piroxicam, felbinac, 4-(4'-pentyn-3'-one)-2,6-di-t-butylphenol, 4-(5'-hexynoyl)-2,6-di-t-butylphenol, 4-((S)-(-)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-((R)-(+)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-(3',3'-dimethoxypropionyl)-2,6-di-t-butylphenol, Manjistha, Guggal, and mixtures thereof.
Claim 9
Dependent Claim
23 words
The composition of claim 7 wherein the anti-inflammatory agent is selected from the group consisting of ibuprofen, naproxen, flufenamic acid, and mixtures thereof.
Claim 10
Dependent Claim
16 words
The composition of claim 5 which comprises from about 85% to about 99% of the carrier.
Claim 11
Dependent Claim
11 words
The composition of claim 9 wherein the carrier comprises an emollient.
Claim 12
Dependent Claim
10 words
The composition of claim 10 wherein the emollient is glycerol.
Claim 13
Dependent Claim
34 words
The composition of claim 10 containing from about 1.0% to about 10% by weight of an emollient which comprises a propoxylated glycerol derivative having the formula: ##STR4## wherein n=1 or 2, and mixtures thereof.
Claim 14
Dependent Claim
50 words
The composition of claim 9 which additionally comprises from about 0.25% to about 3% of an ethylene acrylic acid copolymer having the formula ##STR5## wherein the ratio of x:y is from about 1:9 to about 1:24 and the molecular weight of the copolymer is from about 3500 to about 4500.
Claim 15
Independent Claim
48 words
A method of inhibiting the deleterious effects of ultraviolet light exposure to skin comprising applying a safe and photoprotectively effective amount of tocopherol sorbate and a safe and photoprotectively effective amount of an anti-inflammatory agent to the skin in conjunction with exposure of the skin to ultraviolet light.
Claim 16
Independent Claim
48 words
A method of inhibiting the deleterious effects of ultraviolet light exposure to skin comprising applying a safe and photoprotectively effective amount of tocopherol sorbate and a safe and photoprotectively effective amount of an anti-inflammatory agent to the skin in conjunction with exposure of the skin to ultraviolet light.
Claim 17
Dependent Claim
27 words
The method of claim 14 wherein the tocopherol sorbate and the anti-inflammatory agent are applied to the skin prior to exposure of the skin to ultraviolet light.
Claim 18
Dependent Claim
39 words
The method of claim 14 wherein from about 0.05 mg/cm 2 to about 0.5 mg/cm 2 of tocopherol sorbate, and from about 0.01 mg/cm 2 to about 0.1 mg/cm 2 of the anti-inflammatory agent are applied to the skin.
Claim 19
Dependent Claim
37 words
The method of claim 16 wherein the anti-inflammatory agent is selected from the group consisting of hydrocortisone, ibuprofen, naproxen, flufenamic acid, mefenamic acid, meclofenamic acid, piroxicam, felbinac, 4-(4'-pentyn-3'-pentyn-3'-one)-2,6-di-t-butylphenol, 4-(5'-hexynoyl)-2,6-di-t-butylphenol, 4-((S)-(-)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-((R)-(+)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-(3',3'-dimethoxypropionyl)-2,6-di-t-butylphenol, Manjistha, Guggal, and mixtures thereof.
Claim 20
Dependent Claim
23 words
The method of claim 17 wherein the anti-inflammatory agent is selected from the group consisting of ibuprofen, naproxen, flufenamic acid, and mixtures thereof.
Claim 21
Dependent Claim
25 words
The method of claim 14 wherein the tocopherol sorbate and the anti-inflammatory agent are applied to the skin up to 30 minutes after UV exposure.
Claim 22
Dependent Claim
27 words
The method of claim 15 wherein the tocopherol sorbate and the anti-inflammatory agent are applied to the skin up to about 4 hours prior to UV exposure.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |