US4954332A
Expired / Lapsed
US
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Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent
Assignee: Procter and Gamble Co
•
Filing: 1989-06-26
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Granted: 1990-09-04
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Expires: 2009-06-26
Abstract
Abstract Disclosed are pharmaceutical compositions comprising tocopherol sorbate and an anti-inflammatory agent which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of tocopherol sorbate, an anti-inflammatory agent, and a sunscreen are also disclosed. Also disclosed is a method for using these compositions topically to prevent damage to skin caused by acute or chronic UV exposure.
Inventors
- 👤 Donald L. Bissett
- 👤 Rodney D. Bush
- 👤 Ranjit Chatterjee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 01:45
CPC Classifications
A; A61; A61Q; A61Q17/00; A61Q17/04; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/40; A61K8/44; A61K8/445; A61K8/49; A61K8/4973; A61K8/498; A61K8/67; A61K8/678; A61Q19/00; A61Q19/10; A61Q5/00; A61Q5/02; Y; Y10; Y10S; Y10S424/00; Y10S424/05
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
146 words
A photoprotective composition useful for topical application comprising: (a) a safe and photoprotectively effective amount of a radical scavenging compound selected from the group consisting of tocopherol and tocopherol esters selected from acetate, succinate, propionate, oleate, orotate, benzoate, p-aminobenzoate, p-nitrobenzoate, linoleate, nicotinate, 2-ethylhexanoate and sorbate, and mixtures thereof; (b) a safe and photoprotectively effective amount of an anti-inflammatory agent selected from the group consisting of a steroidal anti-inflammatory agent; a non-steroidal anti-inflammatory agent selected from the group consisting of the oxicams, the salicylates, the acetic acid derivatives, the fenamates, the propionic acid derivatives, the pyrazoles, the 2,6-di-tert-butyl phenol derivatives, and the 2-naphtyl-containing ester compounds; and a natural anti-inflammatory agent selected from the group consisting of candelilla wax, alpha bisabolol, Aloe vera, Manjistha, and Guggal; (c) a safe and photoprotectively effective amount of a sunscreening agent; and (d) a safe and effective amount of a topical carrier.
Claim 2
Dependent Claim
146 words
A photoprotective composition useful for topical application comprising: (a) a safe and photoprotectively effective amount of a radical scavenging compound selected from the group consisting of tocopherol and tocopherol esters selected from acetate, succinate, propionate, oleate, orotate, benzoate, p-aminobenzoate, p-nitrobenzoate, linoleate, nicotinate, 2-ethylhexanoate and sorbate, and mixtures thereof; (b) a safe and photoprotectively effective amount of an anti-inflammatory agent selected from the group consisting of a steroidal anti-inflammatory agent; a non-steroidal anti-inflammatory agent selected from the group consisting of the oxicams, the salicylates, the acetic acid derivatives, the fenamates, the propionic acid derivatives, the pyrazoles, the 2,6-di-tert-butyl phenol derivatives, and the 2-naphtyl-containing ester compounds; and a natural anti-inflammatory agent selected from the group consisting of candelilla wax, alpha bisabolol, Aloe vera, Manjistha, and Guggal; (c) a safe and photoprotectively effective amount of a sunscreening agent; and (d) a safe and effective amount of a topical carrier.
Claim 3
Dependent Claim
13 words
The composition of claim 1 wherein the radical scavenging compound is tocopherol sorbate.
Claim 4
Dependent Claim
16 words
The composition of claim 2 which comprises from about 1% to about 10% of tocopherol sorbate.
Claim 5
Dependent Claim
17 words
The composition of claim 3 which comprises from about 0.2% to about 5% of the anti-inflammatory agent.
Claim 6
Dependent Claim
17 words
The composition of claim 4 which comprises from about 1% to about 10% of the sunscreening agent.
Claim 7
Dependent Claim
72 words
The composition of claim 5 wherein the sunscreening agent is selected from the group consisting of 2-ethylhexyl p-methoxycinnamate, butyl methoxydibenzoylmethane, 2-hydroxy-4 methoxybenzophenone, octyl dimethyl p-aminobenzoic acid, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, the N,N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 4-hydroxydibenzoylmethane, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 4-hydroxydibenzoyl methane, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 4-(2-hydroxyethoxy)dibenzoylmethane, the N-N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, the N,N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 4-(2-hydroxyethoxy)dibenzoylmethane and mixtures thereof.
Claim 8
Dependent Claim
56 words
The composition of claim 6 wherein the anti-inflammatory agent is selected from the group consisting of ibuprofen, naproxen, and flufenamic acid, and the sunscreening agent is selected from the group consisting of 2-ethylhexyl p-methoxycinnamate, butyl methoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyl dimethyl p-aminobenzoic acid, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 4-(2-hydroxyethoxy)dibenzoylmethane and mixtures thereof.
Claim 9
Independent Claim
53 words
A method of inhibiting the deleterious effects of ultraviolet light exposure to skin comprising applying a safe and photoprotectively effective amount of tocopherol sorbate, a safe and photoprotectively effective amount of an anti-inflammatory agent and a safe and photoprotectively effective amount of a sunscreening agent to the skin in conjunction with UV exposure.
Claim 10
Independent Claim
53 words
A method of inhibiting the deleterious effects of ultraviolet light exposure to skin comprising applying a safe and photoprotectively effective amount of tocopherol sorbate, a safe and photoprotectively effective amount of an anti-inflammatory agent and a safe and photoprotectively effective amount of a sunscreening agent to the skin in conjunction with UV exposure.
Claim 11
Dependent Claim
52 words
The method of claim 8 wherein from about 0.05 mg/cm 2 to about 0.5 mg/cm 2 tocopherol sorbate, from about 0.01 mg/cm 2 to about 0.1 mg/cm 2 of the anti-inflammatory agent, and from about 0.05 mg/cm 2 to about 0.5 mg/cm 2 of the sunscreening agent is applied to the skin.
Claim 12
Dependent Claim
70 words
The method of claim 9 wherein the sunscreening agent is selected from the group consisting of 2-ethylhexyl p-methoxycinnamate, butyl methoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyl dimethyl p-aminobenzoic acid, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2,4-dihydroxybenzophenone, the N,N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 4-hydroxy-dibenzoylmethane, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 4-hydroxydibenzoylmethane, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 4-(2-hydroxyethoxy)dibenzoylmethane, the N-N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, the N,N-di-(2-ethylhexyl)-4-aminobenzoic acid ester of 4-(2-hydroxyethoxy)dibenzoylmethane and mixtures thereof.
Claim 13
Dependent Claim
39 words
The method of claim 10 wherein the sunscreening agent is selected from the group consisting of 2-ethylhexyl p-methoxycinnamate, butyl methoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyldimethyl p-aminobenzoic acid, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 2-hydroxy-4-(2-hydroxyethoxy)benzophenone, the 4-N,N-(2-ethylhexyl)methylaminobenzoic acid ester of 4-(2-hydroxyethoxy)-dibenzoylmethane, and mixtures thereof.
Claim 14
Dependent Claim
38 words
The method of claim 10 wherein the anti-inflammatory agent is selected from the group consisting of hydrocortisone acetate, ibuprofen, naproxen, flufenamic acid, mefenamic acid, meclofenamic acid, piroxicam, felbinac, 4-(4'-pentyn-3'-one)-2,6-di-t-butylphenol, 4-(5'-hexynoyl)-2,6-di-t-butylphenol, 4-((S)-(-)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-((R)-(+)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-(3',3'-dimethoxypropionyl)-2,6-di-t-butylphenol, Manjistha, Guggal, and mixtures thereof.
Claim 15
Dependent Claim
23 words
The method of claim 12 wherein the anti-inflammatory agent is selected from the group consisting of ibuprofen, naproxen, flufenamic acid, and mixtures thereof.
Claim 16
Dependent Claim
27 words
The method of claim 8 wherein the tocopherol sorbate, anti-inflammatory agent, and sunscreening agent are applied to the skin up to 4 hours prior to UV exposure.
Claim 17
Dependent Claim
26 words
The method of claim 8 wherein the tocopherol sorbate, anti-inflammatory agent, and sunscreening agent are applied to the skin up to 30 minutes after UV exposure.
Claim 18
Independent Claim
30 words
A method of inhibiting the chronic deleterious effects of ultraviolet exposure to skin comprising chronic application of a safe and photoprotectively effective amount of an anti-inflammatory agent to the skin.
Claim 19
Independent Claim
30 words
A method of inhibiting the chronic deleterious effects of ultraviolet exposure to skin comprising chronic application of a safe and photoprotectively effective amount of an anti-inflammatory agent to the skin.
Claim 20
Dependent Claim
25 words
The method of claim 16 wherein from about 0.01 mg/cm 2 to about 0.1 mg/cm 2 of the anti-inflammatory agent is applied to the skin.
Claim 21
Dependent Claim
38 words
The method of claim 17 wherein the anti-inflammatory agent is selected from the group consisting of hydrocortisone acetate, ibuprofen, naproxen, flufenamic acid, mefenamic acid, meclofenamic acid, piroxicam, felbinac, 4-(4'-pentyn-3'-one)-2,6-di-t-butylphenol, 4-(5'-hexynoyl)-2,6-di-t-butylphenol, 4-((S)-(-)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-((R)-(+)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-(3',3'-dimethoxypropionyl)-2,6-di-t-butylphenol, Manjistha, Guggal, and mixtures thereof.
Claim 22
Dependent Claim
23 words
The method of claim 16 wherein the anti-inflammatory agent is applied to the skin from about 1 times to about 3 times daily.
Claim 23
Dependent Claim
23 words
The method of claim 16 wherein the anti-inflammatory agent is applied to the skin at least once daily for at least 10 days.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1993-09-03 | 1994-03-05 | 1994-09-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-09-03 | 1998-03-05 | 1998-09-04 | $3760.00 | Window Closed / Lapsed |
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