US4847069A
Expired / Lapsed
US
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Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent
Assignee: Procter and Gamble Co
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Filing: 1987-10-22
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Granted: 1989-07-11
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Expires: 2007-10-22
Abstract
Abstract Disclosed are pharmaceutical compositions comprising sorbohydroxamic acid, or pharmaceutically-acceptable salts thereof, and an anti-inflammatory agent, which are useful for topical application to prevent damage to skin caused by acute or chronic UV exposure. Combinations of sorbohydroxamic acid and an anti-inflammatory agent together with tocopherol sorbate and/or sunscreens are also disclosed. Also disclosed is a method for using these compositions topically to prevent damage to skin caused by acute or chronic UV exposure.
Inventors
- 👤 Donald Lynn Bissett
- 👤 Ranjit Chatterjee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 16:35
CPC Classifications
A; A61; A61Q; A61Q17/00; A61Q17/04; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/40; A61K8/44; A61K8/445; A61K8/49; A61K8/4973; A61K8/498; A61K8/67; A61K8/678; A61K8/72; A61K8/81; A61K8/8135; A61K8/84; A61K8/89; A61Q1/00; A61Q1/02; A61Q1/04; A61Q1/06; A61Q19/00; A61Q19/10; A61Q5/00; A61Q5/02
Claims Analysis
Total Claims: 32
Claim 1
Independent Claim
117 words
A photoprotective composition useful for topical application comprising: (a) a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof; (b) a safe and photoprotectively effective amount of an anti-inflammatory agent selected from the group consisting of a steroidal anti-inflammatory agent; a nonsteroidal anti-inflammatory agent selected from the group consisting of the oxicams, the salicylates, the acetic acid derivatives, the fenamates, the propionic acid derivatives, the pyrazoles, the 2,6-di-tert-butyl phenol derivatives, and the 2-napthyl-containing ester compounds; and a natural anti-inflammatory agent selected from the group consisting of candelilla wax, alpha bisabolol, aloe vera, Manjistha, and Guggal; and (c) a safe and effective amount of a topical carrier.
Claim 2
Dependent Claim
117 words
A photoprotective composition useful for topical application comprising: (a) a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof; (b) a safe and photoprotectively effective amount of an anti-inflammatory agent selected from the group consisting of a steroidal anti-inflammatory agent; a nonsteroidal anti-inflammatory agent selected from the group consisting of the oxicams, the salicylates, the acetic acid derivatives, the fenamates, the propionic acid derivatives, the pyrazoles, the 2,6-di-tert-butyl phenol derivatives, and the 2-napthyl-containing ester compounds; and a natural anti-inflammatory agent selected from the group consisting of candelilla wax, alpha bisabolol, aloe vera, Manjistha, and Guggal; and (c) a safe and effective amount of a topical carrier.
Claim 3
Dependent Claim
28 words
The composition of claim 1 which comprises from about 1% to about 10% of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof.
Claim 4
Dependent Claim
28 words
The composition of claim 2 which comprises from about 1% to about 5% of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof.
Claim 5
Dependent Claim
17 words
The composition of claim 2 which comprises from about 0.2% to about 5% of the anti-inflammatory agent.
Claim 6
Dependent Claim
17 words
The composition of claim 4 which comprises from about 0.5% to about 2% of the anti-inflammatory agent.
Claim 7
Dependent Claim
37 words
The composition of claim 4 wherein the anti-inflammatory agent is selected from the group consisting of hydrocortisone, ibuprofen, naproxen, flufenamic acid, mefenamic acid, meclofenamic acid, piroxicam, felbinac, 4-(4'-pentyn-3'-one)-2,6-di-t-butylphenol, 4-(5'-hexynoyl)-2,6-di-t-butylphenol, 4-((S)-(-)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-((R)-(+)-3'-methyl-5'-hexynoyl)-2,6-di-t-butylphenol, 4-(3',3'-dimethoxypropinyl)-2,6-di-t-butylphenol, Manjistha, Guggal, and mixtures thereof.
Claim 8
Dependent Claim
23 words
The composition of claim 6 wherein the anti-inflammatory agent is selected from the group consisting of ibuprofen, naproxen, flufenamic acid, and mixtures thereof.
Claim 9
Dependent Claim
16 words
The composition of claim 4 which comprises from about 85% to about 99% of the carrier.
Claim 10
Dependent Claim
13 words
The composition of claim 8 which is in the form of a solution.
Claim 11
Dependent Claim
19 words
The composition of claim 9 which additionally comprises a thickening agent in an amount sufficient to form a gel.
Claim 12
Dependent Claim
19 words
The composition of claim 9 which additionally comprises a propellant in an amount sufficient to form an aerosol spray.
Claim 13
Dependent Claim
11 words
The composition of claim 4 wherein the carrier comprises an emollient.
Claim 14
Dependent Claim
73 words
The composition of claim 9 wherein the emollient is selected from the group consisting of hydrocarbon oils and waxes, silicone oils, triglyceride esters, acetoglyceride esters, ethoxylated glycerides, alkyl esters of fatty acids, alkenyl esters of fatty acids, fatty acids, fatty alcohols, fatty alcohol ethers, esters of ethoxylated fatty alcohols, lanolin and its derivatives, polyhydric alcohols and polyether derivatives, polyhydric alcohol esters, wax esters, beeswax derivatives, vegetable waxes, phospholipids, sterols, amides, and mixtures thereof.
Claim 15
Dependent Claim
10 words
The composition of claim 12 wherein the emollient is glycerol.
Claim 16
Dependent Claim
33 words
The composition of claim 12 containing from about 1% to about 10% by weight of emollient which comprises a propoxylated glycerol derivative having the formula: ##STR5## wherein n=1 or 2, and mixtures thereof.
Claim 17
Dependent Claim
13 words
The composition of claim 8 which is in the form of an emulsion.
Claim 18
Dependent Claim
20 words
The composition of claim 14 wherein the emulsion comprises from about 1% to about 10% by weight of an emulsifier.
Claim 19
Dependent Claim
13 words
The composition of claim 15 wherein the emulsifier is an organic nonionic surfactant.
Claim 20
Dependent Claim
11 words
The composition of claim 16 which is formulated as a lotion.
Claim 21
Dependent Claim
11 words
The composition of claim 16 which is formulated as a cream.
Claim 22
Dependent Claim
102 words
The composition of claim 8 wherein the carrier comprises an oil-in-water-in-silicone fluid emulsion composition comprising: (a) from about 15% to about 90% by weight of the emulsion composition of a silicone fluid continuous phase consisting essentially of at least one liquid organopolysiloxane; (b) from about 30% to about 80% by weight of the emulsion composition of an aqueous discontinuous phase comprising an oil-in-water emulsion of a cosmetically-acceptable oily liquid non-particulate phase dispersed in an aqueous phase; and (c) from about 0.5% to about 5% by weight of emulsion composition of an effective dispersing amount of dimethicone copolyol for dispersing (b) in (a).
Claim 23
Dependent Claim
50 words
The composition of claim 8 which additionally comprises from about 0.25% to about 3% of an ethylene acrylic acid copolymer having the formula ##STR6## wherein the ratio of x:y is from about 1:9 to about 1:24 and the molecular weight of the copolymer is from about 3500 to about 4500.
Claim 24
Dependent Claim
17 words
The composition of claim 8 which additionally comprises a safe and effective amount of a penetration enhancer.
Claim 25
Independent Claim
126 words
A method of inhibiting the deleterious effects of ultraviolet light exposure to skin comprising applying a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically acceptable salts thereof, and a safe and photoprotectively effective amount of an anti-inflammatory agent selected from the group consisting of a steroidal anti-inflammatory agent; a nonsteroidal anti-inflammatory agent selected from the group consisting of the oxicams, the salicylates, the acetic acid derivatives, the fenamates, the propionic acid derivatives, the pyrazoles, the 2,6-di-tert-butyl phenol derivatives, and the 2-napthyl-containing ester compounds; and a natural anti-inflammatory agent selected from the group consisting of candelilla wax, alpha bisabolol, aloe vera, Manjistha, and Guggal, to skin simultaneously in conjunction with exposure of the skin to ultraviolet light.
Claim 26
Independent Claim
126 words
A method of inhibiting the deleterious effects of ultraviolet light exposure to skin comprising applying a safe and photoprotectively effective amount of an agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically acceptable salts thereof, and a safe and photoprotectively effective amount of an anti-inflammatory agent selected from the group consisting of a steroidal anti-inflammatory agent; a nonsteroidal anti-inflammatory agent selected from the group consisting of the oxicams, the salicylates, the acetic acid derivatives, the fenamates, the propionic acid derivatives, the pyrazoles, the 2,6-di-tert-butyl phenol derivatives, and the 2-napthyl-containing ester compounds; and a natural anti-inflammatory agent selected from the group consisting of candelilla wax, alpha bisabolol, aloe vera, Manjistha, and Guggal, to skin simultaneously in conjunction with exposure of the skin to ultraviolet light.
Claim 27
Dependent Claim
38 words
The method of claim 24 wherein the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, and the anti-inflammatory agent are applied to the skin prior to exposure of the skin to ultraviolet light.
Claim 28
Dependent Claim
51 words
The method of claim 24 wherein from about 0.05 mg/cm 2 to about 0.5 mg/cm 2 of the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salt thereof, and from about 0.01 mg/cm 2 to about 0.01 mg/cm 2 of the anti-inflammatory agent are applied to the skin.
Claim 29
Dependent Claim
36 words
The method of claim 26 wherein anti-inflammatory agent is selected from the group consisting of hydrocortisone, ibuprofen, naproxen, flufenamic acid, mefenamic acid, meclofenamic acid, piroxicam, felbinac, 4-(4'-pentyn-3'-one)-2,6-di-t-butylphenol, 4-(5'-hexynoyl)-2,6-di-t-butylphenol, 4-((S)-(-)-3'-methyl-5'-hexynoyl-2,6-di-t-butylphenol, 4-((R)-(+)-3'-methyl-5'-hexynoyl-2,6-di-t-butylphenol, 4-(3',3'-di-t-butylphenol, Manjistha, Guggal, and mixtures thereof.
Claim 30
Dependent Claim
23 words
The method of claim 27 wherein the anti-inflammatory agent is selected from the group consisting of ibuprofen, naproxen, flufenamic acid, and mixtures thereof.
Claim 31
Dependent Claim
36 words
The method of claim 24 wherein the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salt thereof, and the anti-inflammatory agent are applied to the skin up to 30 minutes after UV exposure.
Claim 32
Dependent Claim
38 words
The method of claim 25 wherein the agent selected from the group consisting of sorbohydroxamic acid and pharmaceutically-acceptable salts thereof, and the anti-flammatory agent are applied to the skin up to about 4 hours prior to UV exposure.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-07-10 | 1993-01-09 | 1993-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-07-10 | 1997-01-09 | 1997-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-07-10 | 2001-01-09 | 2001-07-11 | $7700.00 | Window Closed / Lapsed |