US5120831A
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US
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Metal-peptide compositions
Assignee: Procyte Corp
•
Filing: 1989-11-13
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Granted: 1992-06-09
•
Expires: 2009-11-13
Abstract
Abstract There is provided metal-peptide compositions for use as stimulating agents for hair growth in warm-blooded animals. Methods for stimulating the growth of hair in warm-blooded animals are also disclosed. The methods utilize a stimulating effective amount of the metal-petide composition or a pharmaceutical preparation containing the metal-peptide composition.
Inventors
- 👤 Loren R. Pickart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 13:14
CPC Classifications
C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K7/00; C07K7/04; C07K7/06; A; A61; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/30; A61K8/64; A61P; A61P43/00; A61Q; A61Q7/00; C07K5/0815; C07K5/0827; A61K2800/00; A61K2800/40; A61K2800/58; A61K38/00
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
25 words
A metal-peptide having the general formula: glycyl-L-histidyl-L-lysine:X wherein X is a metal ion selected from the group consisting of cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II).
Claim 2
Dependent Claim
25 words
A metal-peptide having the general formula: glycyl-L-histidyl-L-lysine:X wherein X is a metal ion selected from the group consisting of cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II).
Claim 3
Dependent Claim
100 words
A metal-peptide derivative of GHL-X having the general formula: ##STR5## wherein X is a metal ion selected from the group consisting of cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II); and R is selected from the group consisting of an --NH 2 moiety, alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 18 carbon atoms, aryloxy moieties containing from 6 to 12 carbon atoms, and alkylamino moieties containing from 1 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine, L-valyl-L-phenylalanyl-L-valine, L-tryptophan, or (glycyl) n -L-tryptophan where n=1-2.
Claim 4
Dependent Claim
100 words
A metal-peptide derivative of GHL-X having the general formula: ##STR5## wherein X is a metal ion selected from the group consisting of cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II); and R is selected from the group consisting of an --NH 2 moiety, alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 18 carbon atoms, aryloxy moieties containing from 6 to 12 carbon atoms, and alkylamino moieties containing from 1 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine, L-valyl-L-phenylalanyl-L-valine, L-tryptophan, or (glycyl) n -L-tryptophan where n=1-2.
Claim 5
Dependent Claim
30 words
A metal-peptide derivative of GHL-Cu having the general formula: ##STR6## wherein R is an alkylamino moiety containing from 1 to 18 carbon atoms, L-tryptophan or (glycyl) n -L-tryptophan where n=1-2.
Claim 6
Dependent Claim
30 words
A metal-peptide derivative of GHL-Cu having the general formula: ##STR6## wherein R is an alkylamino moiety containing from 1 to 18 carbon atoms, L-tryptophan or (glycyl) n -L-tryptophan where n=1-2.
Claim 7
Dependent Claim
26 words
A metal-peptide having the general formula: glycyl-L-(3-methyl)-histidyl-L-lysine:X wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II).
Claim 8
Dependent Claim
26 words
A metal-peptide having the general formula: glycyl-L-(3-methyl)-histidyl-L-lysine:X wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II).
Claim 9
Dependent Claim
100 words
A metal-peptide derivative of glycyl-L-(3-methyl)-histidyl-L-lysine:X having the general formula: ##STR7## wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II); and R is selected from the group consisting of an --NH 2 moiety, alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 18 carbon atoms, aryloxy moieties containing from 6 to 12 carbon atoms, alkylamino moieties containing from 1 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine, L-valyl-L-phenylalanyl-L-valine, L-tryptophan, or (glycyl) n -L-tryptophan where n=1-2.
Claim 10
Dependent Claim
100 words
A metal-peptide derivative of glycyl-L-(3-methyl)-histidyl-L-lysine:X having the general formula: ##STR7## wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II); and R is selected from the group consisting of an --NH 2 moiety, alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 18 carbon atoms, aryloxy moieties containing from 6 to 12 carbon atoms, alkylamino moieties containing from 1 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine, L-valyl-L-phenylalanyl-L-valine, L-tryptophan, or (glycyl) n -L-tryptophan where n=1-2.
Claim 11
Dependent Claim
26 words
A metal-peptide having the general formula: L-lysyl-L-histidyl-glycine:X wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II) iron(II) and manganese(II).
Claim 12
Dependent Claim
26 words
A metal-peptide having the general formula: L-lysyl-L-histidyl-glycine:X wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II) iron(II) and manganese(II).
Claim 13
Dependent Claim
101 words
A metal-peptide derivative of LHG-X having the general formula: ##STR8## wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II); and R is selected from the group consisting of an --NH 2 moiety, alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 18 carbon atoms, aryloxy moieties containing from 6 to 12 carbon atoms, and alkylamino moieties containing from 1 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine, L-valyl-L-phenylalanyl-L-valine, L-tryptophan, or (glycyl) n -L-tryptophan where n=1-2.
Claim 14
Dependent Claim
101 words
A metal-peptide derivative of LHG-X having the general formula: ##STR8## wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II); and R is selected from the group consisting of an --NH 2 moiety, alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 18 carbon atoms, aryloxy moieties containing from 6 to 12 carbon atoms, and alkylamino moieties containing from 1 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine, L-valyl-L-phenylalanyl-L-valine, L-tryptophan, or (glycyl) n -L-tryptophan where n=1-2.
Claim 15
Dependent Claim
26 words
A metal-peptide having the general formula: L-lysyl-L-(3-methyl)-histidyl-glycine:X wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II).
Claim 16
Dependent Claim
26 words
A metal-peptide having the general formula: L-lysyl-L-(3-methyl)-histidyl-glycine:X wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II).
Claim 17
Dependent Claim
101 words
A metal-peptide derivative of L-lysyl-L-(3-methyl)-histidyl-glycine:X having the general formula: ##STR9## wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II); and R is selected from the group consisting of an --NH 2 moiety, alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 18 carbon atoms, aryloxy moieties containing from 6 to 12 carbon atoms, and alkylamino moieties containing from 1 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine, L-valyl-L-phenylalanyl-L-valine, L-tryptophan, or (glycyl) n -L-tryptophan where n=1-2.
Claim 18
Dependent Claim
101 words
A metal-peptide derivative of L-lysyl-L-(3-methyl)-histidyl-glycine:X having the general formula: ##STR9## wherein X is a metal ion selected from the group consisting of copper(II), cadmium(II), cobalt(II), tin(II), iron(II) and manganese(II); and R is selected from the group consisting of an --NH 2 moiety, alkyl moieties containing from 1 to 18 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 18 carbon atoms, aryloxy moieties containing from 6 to 12 carbon atoms, and alkylamino moieties containing from 1 to 18 carbon atoms, or where R is L-prolyl-L-valyl-L-phenylalanyl-L-valine, L-valyl-L-phenylalanyl-L-valine, L-tryptophan, or (glycyl) n -L-tryptophan where n=1-2.
Claim 19
Dependent Claim
26 words
The metal-peptide of any one of claims 1-9 further including a vehicle which adapts the metal-peptide for intradermal injection or topical application to a warm-blooded animal.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-06-09 | 1995-12-09 | 1996-06-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-06-09 | 1999-12-09 | 2000-06-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-06-09 | 2003-12-09 | 2004-06-09 | $7700.00 | Window Closed / Lapsed |