US4760051A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Use of GHL-Cu as a wound-healing and anti-inflammatory agent
Assignee: Procyte Corp
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Filing: 1985-01-24
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Granted: 1988-07-26
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Expires: 2005-01-24
Abstract
Abstract A method of enhancing the wound-healing process in animals utilizing glycyl-1-histidyl-1-lysine: copper(II) (GHL-Cu) is disclosed. GHL-Cu functions as a superoxide dismutase which detoxifies tissue-damaging oxygen radicals, but does not evoke an antigenic response. A method of treating inflammatory conditions in animals and a method of reducing the traumatic effects in animals occurring subsequent to major tissue damage utilizing GHL-Cu is also disclosed.
Inventors
- 👤 Loren R. Pickart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:07
CPC Classifications
A; A61; A61K; A61K38/00; A61K38/04; A61K38/06; A61P; A61P17/00; A61P29/00; A61P43/00; A61P7/00; A61P9/00
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
25 words
A method for enhancing the wound-healing process in an animal comprising administering to the animal a therapeutically effective amount of a composition containing glcyl-L-histidyl-L-lysine: copper(II).
Claim 2
Independent Claim
25 words
A method for enhancing the wound-healing process in an animal comprising administering to the animal a therapeutically effective amount of a composition containing glcyl-L-histidyl-L-lysine: copper(II).
Claim 3
Dependent Claim
26 words
The method of claim 1 wherein said composition is administered through intravenous injection, topical application, or injection into the wound or the area surrounding the wound.
Claim 4
Dependent Claim
15 words
The method of claim 1 wherein said composition further includes an effective amount of dimethylsulfoxide.
Claim 5
Dependent Claim
22 words
The method of claim 1 wherein said composition is admixed with a pharmaceutically acceptable vehicle prior to being administered to said animal.
Claim 6
Dependent Claim
17 words
The method of claim 4 wherein said pharmaceutically acceptable vehicle is phosphate-buffered saline at a physiological pH.
Claim 7
Independent Claim
23 words
A method of treating inflammatory conditions in animals comprising administering to the animal an antiinflammatorily effective amount of a composition containing glycyl-L-histidyl-L-lysine: copper(II).
Claim 8
Independent Claim
23 words
A method of treating inflammatory conditions in animals comprising administering to the animal an antiinflammatorily effective amount of a composition containing glycyl-L-histidyl-L-lysine: copper(II).
Claim 9
Dependent Claim
32 words
The method of claim 6 wherein said composition is administered through intravenous injection, topical application, or injection into the wound or inflamed area, or the area surrounding the wound or inflamed area.
Claim 10
Dependent Claim
15 words
The method of claim 6 wherein said composition further includes an effective amount of dimethylsulfoxide.
Claim 11
Dependent Claim
22 words
The method of claim 6 wherein said composition is admixed with a pharmaceutically acceptable vehicle prior to being administered to said animal.
Claim 12
Dependent Claim
17 words
The method of claim 9 wherein said pharmaceutically acceptable vehicle is phosphate-buffered saline at a physiological pH.
Claim 13
Independent Claim
27 words
A method of inhibiting a rise in blood fibrinogen in injured animals comprising administering to the animal a therapeutically effective amount of a composition containing glycyl-L-histidyl-L-lysine: copper(II).
Claim 14
Independent Claim
27 words
A method of inhibiting a rise in blood fibrinogen in injured animals comprising administering to the animal a therapeutically effective amount of a composition containing glycyl-L-histidyl-L-lysine: copper(II).
Claim 15
Dependent Claim
16 words
The method of claim 11 wherein said composition is administered through intraveneous injection, or intraperitoneal injection.
Claim 16
Dependent Claim
15 words
The method of claim 11 wherein said composition further includes an effective amount of dimethylsulfoxide.
Claim 17
Dependent Claim
22 words
The method of claim 11 wherein said composition is admixed with a pharmaceutically acceptable vehicle prior to being administered to said animal.
Claim 18
Dependent Claim
17 words
The method of claim 14 wherein said pharmaceutically acceptable vehicle is phosphate-buffered saline at a physiological pH.
Claim 19
Independent Claim
34 words
A method of reducing hyperfibrinogenemia, thromboembolism, shock or loss of ambulatory desires in animals occuring subsequent to major tissue damage, comprising administering to the animal an effective amount of a composition containing glycyl-L-histidyl-L-lysine: copper(II).
Claim 20
Independent Claim
34 words
A method of reducing hyperfibrinogenemia, thromboembolism, shock or loss of ambulatory desires in animals occuring subsequent to major tissue damage, comprising administering to the animal an effective amount of a composition containing glycyl-L-histidyl-L-lysine: copper(II).
Claim 21
Dependent Claim
16 words
The method of claim 16 wherein said composition is administered through intraveneous injection, or intraperitoneal injection.
Claim 22
Dependent Claim
15 words
The method of claim 16 wherein said composition further includes an effective amount of dimethylsulfoxide.
Claim 23
Dependent Claim
22 words
The method of claim 16 wherein said composition is admixed with a pharmaceutically acceptable vehicle prior to being administered to said animal.
Claim 24
Dependent Claim
17 words
The method of claim 16 wherein said pharmaceutically acceptable vehicle is phosphate-buffered saline at a physiological pH.
References Cited (Backward Citations)
US3551554A
Cited
US4440788A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-26 | 1992-01-25 | 1992-07-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-26 | 1996-01-25 | 1996-07-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-26 | 2000-01-25 | 2000-07-26 | $7700.00 | Window Closed / Lapsed |