US4022888A
Expired / Lapsed
US
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Esterified orgotein
Assignee: GT Biopharma Inc
•
Filing: 1975-09-09
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Granted: 1977-05-10
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Expires: 1995-09-09
Abstract
Abstract Esterified orgotein, like the native protein, possesses Superoxide Dismutase and anti-inflammatory activity.
Inventors
- 👤 Wolfgang Huber
- 👤 Mark G. Saifer
- 👤 Lewis D. Williams
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 15:12
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/0004; C12N9/0089; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
71 words
An esterified orgotein wherein up to 8 of the free carboxylic acid groups of the orgotein protein molecule are esterified with a physiologically acceptable group, and the esterified acid groups are -COOR, wherein R is alkyl of 1-4 carbon atoms, CH(phenyl) 2 or -- CH 2 COX, wherein X is OCH 3 , OC 2 H 5 , NH 2 , NHCH 2 CONH 2 or CH 2 CH 2 phenyl.
Claim 2
Dependent Claim
71 words
An esterified orgotein wherein up to 8 of the free carboxylic acid groups of the orgotein protein molecule are esterified with a physiologically acceptable group, and the esterified acid groups are -COOR, wherein R is alkyl of 1-4 carbon atoms, CH(phenyl) 2 or -- CH 2 COX, wherein X is OCH 3 , OC 2 H 5 , NH 2 , NHCH 2 CONH 2 or CH 2 CH 2 phenyl.
Claim 3
Dependent Claim
11 words
The orgotein ester of claim 1, wherein the orgotein is bovine.
Claim 4
Dependent Claim
17 words
The orgotein ester of claim 1, having from 1 to 6 esterified carboxylic acid groups per molecule.
Claim 5
Dependent Claim
11 words
The orgotein ester of claim 3, wherein the orgotein is bovine.
Claim 6
Dependent Claim
18 words
The orgotein ester of claim 1, wherein the esters are alkyl esters of 1 to 4 carbon atoms.
Claim 7
Dependent Claim
12 words
The orgotein ester of claim 1, wherein the esters are methyl esters.
Claim 8
Dependent Claim
11 words
The orgotein ester of claim 6, wherein the orgotein is bovine.
Claim 9
Dependent Claim
17 words
The orgotein ester of claim 6, having from 1 to 6 esterified carboxylic acid groups per molecule.
Claim 10
Dependent Claim
29 words
A pharmaceutical composition having antiinflammatory activity comprising, in admixture with a pharmaceutically acceptable carrier, an anti inflammatorily effective amount per unit dosage of an orgotein ester of claim 1.
Claim 11
Dependent Claim
11 words
The pharmaceutical composition according to claim 9. in sterile injectable form.
References Cited (Backward Citations)
US3687927A
Cited
US3758682A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-09 | 1980-11-08 | 1981-05-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-09 | 1984-11-08 | 1985-05-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-09 | 1988-11-08 | 1989-05-10 | $7700.00 | Window Closed / Lapsed |