US4665054A
Expired / Lapsed
US
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Chemical derivatives of GHL-Cu
Assignee: BIOHEAL Inc A CORP OF WA
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Filing: 1985-02-08
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Granted: 1987-05-12
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Expires: 2005-02-08
Abstract
Abstract Derivatives of GHL-Cu possessing greater resistance to proteolytic enzyme breakdown are disclosed. These derivatives can be tailored to increse their fat solubility, making them more useful in the formation of pharmaceutical creams and gels. Further, the derivatives of the present invention possess significant superoxide dismustase activity, making them useful for enhancing the wound-healing process in animals.
Inventors
- 👤 Loren R. Pickart
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 20:00
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/19; A61K8/30; A61K8/64; A61P; A61P29/00; A61P43/00; A61Q; A61Q7/00; C; C07; C07K; C07K5/00; C07K5/04; C07K5/08; C07K5/0827; A61K2800/00; A61K2800/40; A61K2800/58; A61K38/00
Claims Analysis
Total Claims: 31
Claim 1
Independent Claim
77 words
Derivatives of GHL-Cu which possess wound-healing activity, said derivatives further possessing greater resistance to proteolytic enzyme breakdown, said derivatives having the general formula: [glycyl-L-histidyl-L- ##STR1## copper (II) wherein R is selected from the group consisting of an NH 2 moiety, alkyl moieties containing from 1 to 12 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms.
Claim 2
Dependent Claim
77 words
Derivatives of GHL-Cu which possess wound-healing activity, said derivatives further possessing greater resistance to proteolytic enzyme breakdown, said derivatives having the general formula: [glycyl-L-histidyl-L- ##STR1## copper (II) wherein R is selected from the group consisting of an NH 2 moiety, alkyl moieties containing from 1 to 12 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms.
Claim 3
Dependent Claim
13 words
The derivative of claim 1 wherein the aryl moiety is a benzyl moiety.
Claim 4
Dependent Claim
13 words
The derivative of claim 1 wherein the alkyl moiety is a methyl moiety.
Claim 5
Dependent Claim
13 words
The derivative of claim 1 wherein the alkyl moiety is an unbranched chain.
Claim 6
Dependent Claim
13 words
The derivative of claim 4 wherein the unbranched chain is an n-octyl moiety.
Claim 7
Independent Claim
87 words
A method for enhancing the wound-healing process in an animal, comprising administering to the animal a therapeutically effective amount of a composition containing a derivative of GHL-Cu, said derivatives having the general formula: [glycyl-L-histidyl-L- ##STR2## copper (II) wherein R is selected from the group consisting of an NH 2 moiety, alkyl moieties containing from 1 to 12 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms.
Claim 8
Independent Claim
87 words
A method for enhancing the wound-healing process in an animal, comprising administering to the animal a therapeutically effective amount of a composition containing a derivative of GHL-Cu, said derivatives having the general formula: [glycyl-L-histidyl-L- ##STR2## copper (II) wherein R is selected from the group consisting of an NH 2 moiety, alkyl moieties containing from 1 to 12 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms.
Claim 9
Dependent Claim
13 words
The method of claim 6 wherein the aryl moiety is a benzyl moiety.
Claim 10
Dependent Claim
13 words
The method of claim 6 wherein the alkyl moiety is a methyl moiety.
Claim 11
Dependent Claim
13 words
The method of claim 6 wherein the alkyl moiety is an unbranched chain.
Claim 12
Dependent Claim
13 words
The method of claim 9 wherein the unbranched chain is an n-octyl moiety.
Claim 13
Independent Claim
89 words
A method of inhibiting the production of thromboxane by platelets in animals comprising administering to the animal a therapeutically effective amount of a composition containing a derivative of GHL-Cu, said derivatives having the general formula: [glycyl-L-histidyl-L- ##STR3## copper (II) wherein R is selected from the group consisting of an NH 2 moiety, alkyl moieties containing from 1 to 12 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms.
Claim 14
Independent Claim
89 words
A method of inhibiting the production of thromboxane by platelets in animals comprising administering to the animal a therapeutically effective amount of a composition containing a derivative of GHL-Cu, said derivatives having the general formula: [glycyl-L-histidyl-L- ##STR3## copper (II) wherein R is selected from the group consisting of an NH 2 moiety, alkyl moieties containing from 1 to 12 carbon atoms, aryl moieties containing from 6 to 12 carbon atoms, alkoxy moieties containing from 1 to 12 carbon atoms, and aryloxy moieties containing from 6 to 12 carbon atoms.
Claim 15
Dependent Claim
13 words
The method of claim 11 wherein the aryl moiety is a benzyl moiety.
Claim 16
Dependent Claim
13 words
The method of claim 11 wherein the alkyl moiety is a methyl moiety.
Claim 17
Dependent Claim
13 words
The method of claim 11 wherein the alkyl moiety is an unbranched chain.
Claim 18
Dependent Claim
13 words
The derivative of claim 14 wherein the unbranched chain is an n-octyl moiety.
Claim 19
Dependent Claim
17 words
The derivative of claim 1 wherein said derivatives can be tailored to increase the fat solubility thereof.
Claim 20
Dependent Claim
13 words
The derivative of claim 1 wherein the aryloxy moiety is an O-benzyl moiety.
Claim 21
Dependent Claim
13 words
The derivative of claim 1 wherein the alkoxy moiety is a methoxy moiety.
Claim 22
Dependent Claim
17 words
The derivative of claim 1 wherein the carbon portion of the alkoxy moiety is an unbranched chain.
Claim 23
Dependent Claim
12 words
The derivative of claim 19 wherein the unbranched carbon chain is n-octyl.
Claim 24
Dependent Claim
13 words
The method of claim 6 wherein the aryloxy moiety is an O-benzyl moiety.
Claim 25
Dependent Claim
13 words
The method of claim 6 wherein the alkoxy moiety is a methoxy moiety.
Claim 26
Dependent Claim
17 words
The method of claim 6 wherein the carbon portion of the alkoxy moiety is an unbranched chain.
Claim 27
Dependent Claim
12 words
The method of claim 23 wherein the unbranched carbon chain is n-octyl.
Claim 28
Dependent Claim
13 words
The method of claim 11 wherein the aryloxy moiety is an O-benzyl moiety.
Claim 29
Dependent Claim
13 words
The method of claim 11 wherein the alkoxy moiety is a methoxy moiety.
Claim 30
Dependent Claim
17 words
The method of claim 11 wherein the carbon portion of the alkoxy moiety is an unbranched chain.
Claim 31
Dependent Claim
12 words
The method of claim 27 wherein the unbranched carbon chain is n-octyl.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-11 | 1990-11-10 | 1991-05-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-11 | 1994-11-10 | 1995-05-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-11 | 1998-11-10 | 1999-05-12 | $7700.00 | Window Closed / Lapsed |