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US5100564A
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US
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Blood collection and processing system
Assignee: Pall Corp
•
Filing: 1990-11-06
•
Granted: 1992-03-31
•
Expires: 2010-11-06
Abstract
Abstract A system for collecting and processing donated blood comprises a first porous medium interposed between a blood collection bag and a satellite bag and a second porous medium interposed between the blood collection bag and another satellite bag. The porous media are leucocyte depletion media. The system can be used to centrifuge whole blood into one or more components, and a means for protecting the system during centrifugation including a bracket carried by the centrifuge bucket for receiving the porous media.
Inventors
- 👤 David B. Pall
- 👤 Thomas C. Gsell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 22:13
CPC Classifications
A; A61; A61J; A61J1/00; A61J1/05; A61J1/10; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/0227; A61M1/0231; A61M1/029; A61M1/34; A61M1/3472; A61M1/36; A61M1/3621; A61M1/3627; A61M1/3633; A61M1/3643; A61M1/3644; A61M1/3646; A61M1/3652; B; B01; B01D; B01D61/00; B01D61/14; B01D61/145; B01D61/147; B01D61/16; B01D63/00; B01D63/08; B01D63/087; A61M1/3693; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415; A61M2202/0427; A61M2202/0429; A61M2202/0439; A61M2206/00; A61M2206/10; A61M2206/12; B01D2311/00; B01D2311/04; B04; B04B; B04B5/00; B04B5/04; B04B5/0407; B04B2005/0435
Claims Analysis
Total Claims: 131
Claim 1
Independent Claim
86 words
A blood collection and processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous medium interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; and a second porous medium interposed between the first container and the third container and comprising a leucocyte depletion medium.
Claim 2
Dependent Claim
86 words
A blood collection and processing system comprising a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous medium interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; and a second porous medium interposed between the first container and the third container and comprising a leucocyte depletion medium.
Claim 3
Dependent Claim
27 words
The blood collection and processing system of claim 1 wherein the first container is a blood collection bag and the second and third containers are satellite bags.
Claim 4
Dependent Claim
38 words
The blood collection and processing system of claim 1 wherein the first porous medium and the second porous medium comprise fibers that have been modified by exposure to a monomer comprising a polymerizable group and a hydroxyl-containing group.
Claim 5
Dependent Claim
26 words
The blood collection and processing system of claim 3 wherein the fibers of the porous media have been modified to present hydroxyl groups and carboxyl groups.
Claim 6
Dependent Claim
31 words
The blood collection and processing system of claim 4 wherein the fibers of the first porous medium have been modified with a mixture of monomers comprising hydroxyethyl methacrylate and methacrylic acid.
Claim 7
Dependent Claim
28 words
The blood collection and processing system of claim 5 wherein the methacrylic acid to hydroxyethyl methacrylate monomer weight ratio in the modifying mixture is between 0.01:1 and 0.5:1.
Claim 8
Dependent Claim
34 words
The blood collection and processing system of claim 4 wherein the fibers of the second porous medium have been modified with a mixture of monomers comprising hydroxyethyl methacrylate and methyl acrylate or methyl methacrylate.
Claim 9
Dependent Claim
31 words
The blood collection and processing system of claim 7 wherein the methyl acrylate or methyl methacrylate to hydroxyethyl methacrylate monomer weight ratio in the modifying mixture is between 0.1:1 and 0.4:1.
Claim 10
Dependent Claim
20 words
The blood collection and processing system of claim 1 wherein the first and second porous media comprise polybutylene terephthalate fibers.
Claim 11
Dependent Claim
26 words
The blood collection and processing system of claim 1 wherein the first porous medium comprises the combined leucocyte depletion medium and a red cell barrier medium.
Claim 12
Dependent Claim
38 words
The blood collection and processing system of claim 10 wherein the first porous medium comprises a fibrous medium and wherein the fiber surface area of the first porous medium is about 0.3 to about 2.0 M 2 .
Claim 13
Dependent Claim
28 words
The blood collection and processing system of claim 11 wherein the fiber surface area of the first porous medium is about 0.35 to about 0.6 M 2 .
Claim 14
Dependent Claim
24 words
The blood collection and processing system of claim 11 wherein the first porous medium has a voids volume of about 75% to about 80%.
Claim 15
Dependent Claim
24 words
The blood collection and processing system of claim 10 wherein the first porous medium has a voids volume of about 71% to about 83%.
Claim 16
Dependent Claim
26 words
The blood collection and processing system of claim 10 wherein the flow of the first porous medium is about 2.5 to about 10 cm 2 .
Claim 17
Dependent Claim
27 words
The blood collection and processing system of claim 15 wherein the flow area of the first porous medium is about 3.0 to about 6.0 cm 2 .
Claim 18
Dependent Claim
31 words
The blood collection and processing system of claim 10 wherein the first porous medium has a zeta potential of from about -3 to about -30 millivolts at a pH of 7.3.
Claim 19
Dependent Claim
31 words
The blood collection and processing system of claim 17 wherein the first porous medium has a zeta potential of from about -7 to about -20 millivolts at a pH of 7.3.
Claim 20
Dependent Claim
31 words
The blood collection and processing system of claim 18 wherein the first porous medium has a zeta potential of from about -10 to about -14 millivolts at a pH of 7.3.
Claim 21
Dependent Claim
23 words
The blood collection and processing system of claim 10 wherein the first porous medium has a CWST of greater than about 70 dynes/cm.
Claim 22
Dependent Claim
25 words
The blood collection and processing system of claim 20 wherein the first porous medium has a CWST of about 70 dynes/cm to about 115 dynes/cm.
Claim 23
Dependent Claim
25 words
The blood collection and processing system of claim 21 wherein the first porous medium has a CWST of about 90 dynes/cm to about 100 dynes/cm.
Claim 24
Dependent Claim
25 words
The blood collection and processing system of claim 22 wherein the first porous medium has a CWST of about 93 dynes/cm to about 97 dynes/cm.
Claim 25
Dependent Claim
24 words
The blood collection and processing system of claim 10 wherein the first porous medium permits platelets to pass therethrough but blocks red blood cells.
Claim 26
Dependent Claim
38 words
The blood collection and processing system of claim 1 wherein the first porous medium comprises a fibrous medium and wherein the fiber surface area of the first porous medium is about 0.3 to about 2.0 M 2 .
Claim 27
Dependent Claim
24 words
The blood collection and processing system of claim 1 wherein the first porous medium has a voids volume of about 71% to about 83%.
Claim 28
Dependent Claim
27 words
The blood collection and processing system of claim 1 wherein the flow area of the first porous medium is about 2.5 to about 10 cm 2 .
Claim 29
Dependent Claim
33 words
The blood collection and processing system of claim 1 wherein the first porous medium has a zeta potential of from about 31 3 to about 31 30 millivolts at a pH of 7.3.
Claim 30
Dependent Claim
23 words
The blood collection and processing system of claim 1 wherein the first porous medium has a CWST of greater than about 70 dynes/cm.
Claim 31
Dependent Claim
24 words
The blood collection and processing system of claim 1 wherein the first porous medium permits platelets to pass therethrough but blocks red blood cells.
Claim 32
Dependent Claim
20 words
The blood collection and processing system of claim 1 wherein the first porous medium comprises a red cell barrier medium.
Claim 33
Dependent Claim
38 words
The blood collection and processing system of claim 31 wherein the first porous medium comprises a fibrous medium and wherein the fiber surface area of the first porous medium is about 0.04 to about 0.3 M 2 .
Claim 34
Dependent Claim
24 words
The blood collection and processing system of claim 31 wherein the first porous medium has a voids volume of about 71% to about 83%.
Claim 35
Dependent Claim
27 words
The blood collection and processing system of claim 31 wherein the flow area of the first porous medium is about 3 to about 8 cm 2 .
Claim 36
Dependent Claim
31 words
The blood collection and processing system of claim 31 wherein the first porous medium has a zeta potential of from about -3 to about -30 millivolts at a pH of 7.3.
Claim 37
Dependent Claim
23 words
The blood collection and processing system of claim 31 wherein the first porous medium has a CWST of greater than about 70 dynes/cm.
Claim 38
Dependent Claim
19 words
The blood collection and processing system of claim 1 wherein the first porous medium comprises a leucocyte depletion medium.
Claim 39
Dependent Claim
39 words
The blood collection and processing system of claim 37 wherein the first porous medium comprises a fibrous medium and wherein the fiber surface area of the first porous medium is from about 0.08 to about 1.0 M 2 .
Claim 40
Dependent Claim
24 words
The blood collection and processing system of claim 37 wherein the first porous medium has a voids volume of about 50% to about 89%.
Claim 41
Dependent Claim
31 words
The blood collection and processing system of claim 37 wherein the first porous medium has a zeta potential of from about -3 to about -30 millivolts at a pH of 7.3.
Claim 42
Dependent Claim
23 words
The blood collection and processing system of claim 37 wherein the first porous medium has a CWST of greater than about 70 dynes/cm.
Claim 43
Dependent Claim
26 words
The blood collection and processing system of claim 1 wherein the second porous medium comprises a leucocyte depletion medium for depleting leucocytes from packed red cells.
Claim 44
Dependent Claim
23 words
The blood collection and processing system of claim 42 wherein the second porous medium has a CWST of greater than about 53 dynes/cm.
Claim 45
Dependent Claim
25 words
The blood collection and processing system of claim 43 wherein the second porous medium has a CWST of about 53 dynes/cm to about 90 dynes/cm.
Claim 46
Dependent Claim
24 words
The blood collection and processing system of claim 42 wherein the second porous medium has a voids volume of about 60% to about 90%.
Claim 47
Dependent Claim
24 words
The blood collection and processing system of claim 45 wherein the second porous medium has a voids volume of about 73% to about 88.5%.
Claim 48
Dependent Claim
26 words
The blood collection and processing system of claim 42 wherein the flow of the second porous medium is about 30 to about 60 cm 2 .
Claim 49
Dependent Claim
18 words
The blood collection and processing system of claim 42 wherein the second porous medium also includes a pre-filter.
Claim 50
Dependent Claim
23 words
The blood collection and processing system of claim 1 wherein the second porous medium has a CWST of greater than about 53 dynes/cm.
Claim 51
Dependent Claim
24 words
The blood collection and processing system of claim 1 wherein the second porous medium has a voids volume of about 60% to about 90%.
Claim 52
Dependent Claim
24 words
The blood collection and processing system of claim 50 wherein the second porous medium has a voids volume of about 73% to about 88.5%.
Claim 53
Dependent Claim
27 words
The blood collection and processing system of claim 1 wherein the flow area of the second porous medium is about 30 to about 60 cm 2 .
Claim 54
Dependent Claim
18 words
The blood collection and processing system of claim 1 wherein the second porous medium also includes a pre-filter.
Claim 55
Dependent Claim
31 words
The blood collection and processing system of claim 1 wherein flexible tubing connects the first container to the second container and flexible tubing connects the first container to the third container.
Claim 56
Dependent Claim
40 words
A blood collection and processing system comprising: a bucket; at least one container fitted in the bucket; at least one filter assembly in fluid communication with the container; and a bracket receiving the filter assembly and carried by the bucket.
Claim 57
Dependent Claim
40 words
A blood collection and processing system comprising: a bucket; at least one container fitted in the bucket; at least one filter assembly in fluid communication with the container; and a bracket receiving the filter assembly and carried by the bucket.
Claim 58
Dependent Claim
17 words
The blood collection and processing system of claim 55 wherein the container is a blood collection bag.
Claim 59
Dependent Claim
20 words
The blood collection and processing system of claim 55 comprising a blood collection bag and at least one satellite bag.
Claim 60
Dependent Claim
42 words
The blood collection and processing system of claim 55 wherein the filter assembly comprises a housing and in the housing at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium.
Claim 61
Dependent Claim
20 words
The blood collection and processing system of claim 55 comprising a second filter assembly in fluid communication with the container.
Claim 62
Dependent Claim
33 words
The blood collection and processing system of claim 59 wherein the second filter assembly comprises a housing and in the housing a porous medium for the depletion of leucocytes from packed red cells.
Claim 63
Dependent Claim
44 words
The blood collection and processing system of claim 59 wherein at least one filter assembly is positioned such that the force imposed on the filter assembly during centrifugation is not greater than about 60% of the force imposed at the bottom of the bucket.
Claim 64
Dependent Claim
37 words
The blood collection and processing system of claim 59 wherein at least one filter assembly is positioned outside the bucket when the filter assembly is received in the bucket and the bracket is carried by the bucket.
Claim 65
Dependent Claim
30 words
The blood collection and processing system of claim 59 wherein at least one filter assembly is positioned on the bracket and the bracket rests on or partly within the bucket.
Claim 66
Dependent Claim
42 words
The blood collection and processing system of claim 55 wherein the filter assembly is positioned such that the force imposed on the filter assembly during centrifugation is not greater than about 60% of the force imposed at the bottom of the bucket.
Claim 67
Dependent Claim
35 words
The blood collection and processing system of claim 64 wherein the force imposed on the filter assembly during centrifugation is not greater than about 40% of the force imposed at the bottom of the bucket.
Claim 68
Dependent Claim
35 words
The blood collection and processing system of claim 55 wherein the filter assembly is positioned outside the bucket when the filter assembly is received in the bucket and the bracket is carried by the bucket.
Claim 69
Dependent Claim
28 words
The blood collection and processing system of claim 55 wherein the filter assembly is positioned on the bracket and the bracket rests on or partly within the bucket.
Claim 70
Dependent Claim
52 words
A blood centrifugation and processing system comprising: a centrifuge having at least two buckets; at least one container which fits in a bucket; at least one filter assembly in fluid communication with the container; and a bracket adapted to receive the filter assembly and carried by at least one of said buckets.
Claim 71
Dependent Claim
52 words
A blood centrifugation and processing system comprising: a centrifuge having at least two buckets; at least one container which fits in a bucket; at least one filter assembly in fluid communication with the container; and a bracket adapted to receive the filter assembly and carried by at least one of said buckets.
Claim 72
Dependent Claim
40 words
The blood collection and processing system of claim 68 further comprising a second and a third container, wherein the first container comprises a blood collection bag and said second and third containers comprise a first and second satellite bag, respectively.
Claim 73
Dependent Claim
42 words
The blood collection and processing system of claim 68 wherein the filter assembly comprises a housing and in the housing at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium.
Claim 74
Dependent Claim
22 words
The blood collection and processing system of claim 68 further comprising a second filter assembly in fluid communication with the first container.
Claim 75
Dependent Claim
30 words
The blood collection and processing system of claim 71 wherein the second filter assembly comprises a housing and a porous medium for the depletion of leucocytes from packed red cells.
Claim 76
Dependent Claim
42 words
The blood collection and processing system of claim 68 wherein the filter assembly is positioned such that the force imposed on the filter assembly during centrifugation is not greater than about 60% of the force imposed at the bottom of the bucket.
Claim 77
Dependent Claim
105 words
A blood collection and processing system comprising: a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous fibrous medium interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion and red cell barrier medium; and a second porous fibrous medium interposed between the first container and the third container and comprising a leucocyte depletion medium; the first and second porous media having fibers which have been modified to present hydroxyl groups.
Claim 78
Dependent Claim
105 words
A blood collection and processing system comprising: a first container; a second container in fluid communication with the first container; a third container in fluid communication with the first container; a first porous fibrous medium interposed between the first container and the second container comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion and red cell barrier medium; and a second porous fibrous medium interposed between the first container and the third container and comprising a leucocyte depletion medium; the first and second porous media having fibers which have been modified to present hydroxyl groups.
Claim 79
Dependent Claim
27 words
The blood collection and processing system of claim 74 wherein the first container is a blood collection bag and the second and third containers are satellite bags.
Claim 80
Dependent Claim
31 words
The blood collection and processing system of claim 74 wherein the fibers of the first porous medium have been modified with a mixture of monomers comprising hydroxyethyl methacrylate and methacrylic acid.
Claim 81
Dependent Claim
34 words
The blood collection and processing system of claim 74 wherein the fibers of the second porous medium have been modified with a mixture of monomers comprising hydroxyethyl methacrylate and methyl acrylate or methyl methacrylate.
Claim 82
Dependent Claim
20 words
The blood collection and processing system of claim 74 wherein the first and second porous media comprise polybutylene terephthalate fibers.
Claim 83
Dependent Claim
39 words
The blood collection and processing system of claim 74 wherein fiber surface area in the first porous medium is about 0.3 to about 2.0 M 2 and the flow area is about 2.5 to about 10 cm 2 .
Claim 84
Dependent Claim
24 words
The blood collection and processing system of claim 74 wherein the first porous medium has a voids volume of about 71% to about 83%.
Claim 85
Dependent Claim
40 words
The blood collection and processing system of claim 74 wherein the first porous medium has a zeta potential of from about -3 to about -30 millivolts at a pH of 7.3 and a CWST of greater than about 70 dynes/cm.
Claim 86
Dependent Claim
35 words
The blood collection and processing system of claim 74 wherein the second porous medium comprises a leucocyte depletion medium for depleting leucocytes from packed red cells having a CWST of greater than about 53 dynes/cm.
Claim 87
Dependent Claim
37 words
The blood collection and processing system of claim 74 wherein the second porous medium has a voids volume of about 60% to about 90% and a flow area of about 30 to about 60 cm 2 .
Claim 88
Dependent Claim
18 words
The blood collection and processing system of claim 74 wherein the second porous medium also includes a pre-filter.
Claim 89
Dependent Claim
163 words
A blood collection and processing system comprising a blood collection bag; a first satellite bag; a second satellite bag; tubing connecting the blood collection bag to the first satellite bag and to the second satellite bag; a first porous medium interposed in the tubing between the collection bag and the first satellite bag comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; said first porous medium having a zeta potential of about -3 to about -30 millivolts at pH of 7.3 and a CWST of greater than about 70 dynes/cm; and a second porous medium interposed in the tubing between the collection bag and the second satellite bag and comprising a leucocyte depletion medium, said second porous medium having a CWST of greater than about 53 dynes/cm, a voids volume of about 60% to about 90%, and a flow area of about 30 to about 60 cm 2 .
Claim 90
Dependent Claim
163 words
A blood collection and processing system comprising a blood collection bag; a first satellite bag; a second satellite bag; tubing connecting the blood collection bag to the first satellite bag and to the second satellite bag; a first porous medium interposed in the tubing between the collection bag and the first satellite bag comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; said first porous medium having a zeta potential of about -3 to about -30 millivolts at pH of 7.3 and a CWST of greater than about 70 dynes/cm; and a second porous medium interposed in the tubing between the collection bag and the second satellite bag and comprising a leucocyte depletion medium, said second porous medium having a CWST of greater than about 53 dynes/cm, a voids volume of about 60% to about 90%, and a flow area of about 30 to about 60 cm 2 .
Claim 91
Independent Claim
81 words
A method for collecting and processing blood comprising: collecting whole blood in a container; centrifuging the whole blood; passing the supernatant layer of the centrifuged blood through a first porous medium, the first porous medium comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; and passing the sediment layer of the centrifuged blood through a second porous medium, the second porous medium comprising a leucocyte depletion medium.
Claim 92
Independent Claim
81 words
A method for collecting and processing blood comprising: collecting whole blood in a container; centrifuging the whole blood; passing the supernatant layer of the centrifuged blood through a first porous medium, the first porous medium comprising at least one of a leucocyte depletion medium, a red cell barrier medium, and a combined leucocyte depletion red cell barrier medium; and passing the sediment layer of the centrifuged blood through a second porous medium, the second porous medium comprising a leucocyte depletion medium.
Claim 93
Dependent Claim
71 words
The method of claim 86 wherein centrifuging the whole blood includes separating the whole blood into a supernatant layer and a sediment layer that includes red blood cells, and wherein passing the supernatant layer through the first porous medium comprises passing the centrifuged blood, supernatant layer first, through the red cell barrier medium or the combined leucocyte depletion red cell barrier medium until the red cells block the first porous medium.
Claim 94
Dependent Claim
64 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through fibers that have been modified by exposure to a monomer comprising a hydroxyl-containing group, and wherein passing the sediment layer through a second porous medium comprises passing the layer through fibers that have been modified by exposure to a monomer comprising a hydroxyl-containing group.
Claim 95
Dependent Claim
36 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through fibers that have been modified with a mixture of monomers comprising hydroxyethyl methacrylate and methacrylic acid.
Claim 96
Dependent Claim
39 words
The method of claim 86 wherein passing the sediment layer through a second porous medium comprises passing the layer through fibers that have been modified with a mixture of monomers comprising hydroxyethyl methacrylate and methyl acrylate or methyl methacrylate.
Claim 97
Dependent Claim
42 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through polybutylene terephthalate fibers, and wherein passing the sediment layer through a second porous medium comprises passing the layer through polybutylene terephthalate fibers.
Claim 98
Dependent Claim
31 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through the combined leucocyte depletion medium and a red cell barrier medium.
Claim 99
Dependent Claim
36 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through a medium wherein the fiber surface area is about 0.3 to about 2.0 M 2 .
Claim 100
Dependent Claim
32 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through a medium having a voids volume of about 71% to about 83%.
Claim 101
Dependent Claim
35 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through a medium having a flow area of about 2.5 to about 10 cm 2 .
Claim 102
Dependent Claim
18 words
The method of claim 95 wherein the flow area is about 3.0 to about 6.0 cm 2 .
Claim 103
Dependent Claim
37 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through a medium wherein the zeta potential is about -3 to about -30 millivolts at pH of 7.3.
Claim 104
Dependent Claim
31 words
The method of claim 86 wherein passing the supernatant layer through a first porous medium comprises passing the layer through a medium having a CWST of greater than about 70 dynes/cm.
Claim 105
Dependent Claim
50 words
The method of claim 86 wherein centrifuging of the whole blood comprises positioning the container containing whole blood in a centrifuge bucket and positioning a filter assembly comprising a housing and the second porous medium, on a bracket adapted to receive the filter assembly and carried by the centrifuge bucket.
Claim 106
Dependent Claim
38 words
The method of claim 99 comprising positioning the filter assembly such that the force imposed on the filter assembly during centrifugation is not greater than about 60% of the force imposed at the bottom of the centrifuge bucket.
Claim 107
Dependent Claim
37 words
The method of claim 100 comprising positioning the filter assembly such that the force imposed on the filter assembly during centrifugation is not greater than about 40% of the force imposed at the bottom of the bucket.
Claim 108
Dependent Claim
13 words
The method of claim 99 comprising positioning the filter assembly outside the bucket.
Claim 109
Dependent Claim
22 words
The method of claim 102 comprising positioning the filter assembly on a bracket which rests on or partly within the centrifuge bucket.
Claim 110
Dependent Claim
31 words
The method of claim 86 wherein passing the sediment layer through a second porous medium comprises passing the layer through a leucocyte depletion medium for depleting leucocytes from packed red cells.
Claim 111
Dependent Claim
31 words
The method of claim 86 wherein passing the sediment layer through a second porous medium comprises passing the layer through a medium having a CWST of greater than about 53 dynes/cm.
Claim 112
Dependent Claim
32 words
The method of claim 86 wherein passing the sediment layer through a second porous medium comprises passing the layer through a medium having a voids volume of about 60% to about 90%.
Claim 113
Dependent Claim
32 words
The method of claim 106 wherein passing the sediment layer through a second porous medium comprises passing the layer through a medium having a voids volume of about 73% to about 88.5%.
Claim 114
Dependent Claim
35 words
The method of claim 86 wherein passing the sediment layer through a second porous medium comprises passing the layer through a medium having a flow area of about 30 to about 60 cm 2 .
Claim 115
Dependent Claim
27 words
The method of claim 86 wherein passing the sediment layer through a second porous medium comprises passing the layer through a medium that also includes a pre-filter.
Claim 116
Dependent Claim
38 words
The method of collecting and processing blood of claim 86 wherein the supernatant layer is passed through flexible tubing into the first porous medium, and the sediment layer is passed through flexible tubing into the second porous medium.
Claim 117
Independent Claim
113 words
A method for collecting and processing blood comprising: collecting whole blood in a first container; centrifuging the whole blood into a supernatant component and a sediment component, wherein centrifuging the whole blood comprises positioning the first container containing the whole blood in a centrifuge bucket and positioning a filter assembly comprising a housing and a porous medium on a bracket adapted to receive the filter assembly and carried by the centrifuge bucket; removing the supernatant component from the first container; and passing the sediment component through a porous medium and into another container, wherein the porous medium removes leucocytes from packed red cells and has a CWST of greater than about 53 dynes/cm.
Claim 118
Independent Claim
113 words
A method for collecting and processing blood comprising: collecting whole blood in a first container; centrifuging the whole blood into a supernatant component and a sediment component, wherein centrifuging the whole blood comprises positioning the first container containing the whole blood in a centrifuge bucket and positioning a filter assembly comprising a housing and a porous medium on a bracket adapted to receive the filter assembly and carried by the centrifuge bucket; removing the supernatant component from the first container; and passing the sediment component through a porous medium and into another container, wherein the porous medium removes leucocytes from packed red cells and has a CWST of greater than about 53 dynes/cm.
Claim 119
Dependent Claim
51 words
The method of claim 111 wherein positioning the filter assembly includes locating the filter assembly with regard to the bottom of the bucket such that the force imposed on the filter assembly during centrifugation is not greater than about 60% of the force imposed at the bottom of the centrifuge bucket.
Claim 120
Dependent Claim
51 words
The method of claim 112 wherein positioning the filter assembly includes locating the filter assembly with regard to the bottom of the bucket such that the force imposed on the filter assembly during centrifugation is not greater than about 40% of the force imposed at the bottom of the centrifuge bucket.
Claim 121
Dependent Claim
19 words
The method of claim 113 wherein positioning the filter assembly includes positioning the filter assembly outside the centrifuge bucket.
Claim 122
Dependent Claim
27 words
The method of claim 114 wherein positioning the filter assembly includes positioning the filter assembly on a bracket which rests on or partly within the centrifuge bucket.
Claim 123
Dependent Claim
30 words
The method of claim 111 wherein passing the sediment layer through a porous medium comprises passing the layer through a leucocyte depletion medium for depleting leucocytes from packed red cells.
Claim 124
Dependent Claim
31 words
The method of claim 111 wherein passing the sediment layer through a porous medium comprises passing the layer through a medium having a voids volume of about 60% to about 90%.
Claim 125
Dependent Claim
34 words
The method of claim 111 wherein passing the sediment layer through a porous medium comprises passing the layer through a medium having a flow area of about 30 to about 60 cm 2 .
Claim 126
Dependent Claim
26 words
The method of claim 111 wherein passing the sediment layer through a porous medium comprises passing the layer through a medium that also includes a pre-filter.
Claim 127
Independent Claim
83 words
A method for collecting and processing blood comprising: collecting whole blood in the first container of a blood collection and processing system comprising a first container for whole blood, a second container for a blood component, and a filter assembly interposed between the first container and the second container; placing the first container holding whole blood and the second container in a centrifuge bucket; positioning the filter assembly on a bracket away from the bottom of the centrifuge bucket; and centrifuging the system.
Claim 128
Independent Claim
83 words
A method for collecting and processing blood comprising: collecting whole blood in the first container of a blood collection and processing system comprising a first container for whole blood, a second container for a blood component, and a filter assembly interposed between the first container and the second container; placing the first container holding whole blood and the second container in a centrifuge bucket; positioning the filter assembly on a bracket away from the bottom of the centrifuge bucket; and centrifuging the system.
Claim 129
Dependent Claim
51 words
The method of claim 120 wherein positioning the filter assembly includes locating the filter assembly with regard to the bottom of the bucket such that the force imposed on the filter assembly during centrifugation is not greater than about 60% of the force imposed at the bottom of the centrifuge bucket.
Claim 130
Dependent Claim
19 words
The method of claim 120 wherein positioning the filter assembly includes positioning the filter assembly outside the centrifuge bucket.
Claim 131
Dependent Claim
24 words
The method of claim 120 wherein positioning the filter assembly includes positioning the filter assembly on a bracket which rests on the centrifuge bucket.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1995-03-31 | 1995-09-30 | 1996-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1999-03-31 | 1999-09-30 | 2000-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2003-03-31 | 2003-09-30 | 2004-03-31 | $7700.00 | Window Closed / Lapsed |