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Oscillometric blood pressure device

Assignee: U S Medical Corp
•
Filing: 1989-12-26
•
Granted: 1991-10-08
•
Expires: 2009-12-26
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Abstract

Abstract An oscillometric blood pressure measuring device (200) is disclosed for determining systolic, mean and diastolic blood pressures. The device (200) includes a cuff (202) adapted to be continuously deflated during a measuring cycle. Analog signals representative of pulsatile changes in cuff pressure are utilized to generate signals representative of pulse characteristics, including peak amplitude and pulse integral characteristics. Difference signals are then generated for the pulses, representative of the difference between peak amplitudes and pulse integrals, and a determination is made as to the systolic and diastolic blood pressure based on these difference signals and static cuff pressures.

Inventors

  • 👤 Gerard M. Lazzaro
  • 👤 Raymond J. Huey

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 19:34
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/02; A61B5/021; A61B5/022; A61B5/02225; A61B5/72; A61B5/7235; A61B5/7242

Claims Analysis

Total Claims: 39
Claim 1
Independent Claim 203 words
An oscillometric blood pressure device for measuring systolic and diastolic blood pressures, and adapted to be interconnected to a cuff attachable to a test subject, said blood pressure device comprising: means adapted to be coupled to said cuff for applying an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; means adapted to be coupled to said cuff for decreasing said occluding pressure to a pressure below said diastolic pressure; a pressure transducer adapted to be coupled to said cuff for generating analog pressure signals representative of instantaneous cuff pressure, said analog pressure signals comprising a first analog signal representative of blood pressure pulses occurring in said artery, and a second analog signal representative of static cuff pressure; circuit means responsive to said first analog signal for generating, for each of said blood pressure pulses, a difference measurement indicative of the difference between a peak amplitude of a pulse and an integral of said pulse, so that for a plurality of said blood pressure pulses, said circuit means generates a plurality of difference measurements; and said circuit means generates signals indicating values of said systolic pressure and said diastolic pressure based on said difference measurements.
Claim 2
Dependent Claim 203 words
An oscillometric blood pressure device for measuring systolic and diastolic blood pressures, and adapted to be interconnected to a cuff attachable to a test subject, said blood pressure device comprising: means adapted to be coupled to said cuff for applying an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; means adapted to be coupled to said cuff for decreasing said occluding pressure to a pressure below said diastolic pressure; a pressure transducer adapted to be coupled to said cuff for generating analog pressure signals representative of instantaneous cuff pressure, said analog pressure signals comprising a first analog signal representative of blood pressure pulses occurring in said artery, and a second analog signal representative of static cuff pressure; circuit means responsive to said first analog signal for generating, for each of said blood pressure pulses, a difference measurement indicative of the difference between a peak amplitude of a pulse and an integral of said pulse, so that for a plurality of said blood pressure pulses, said circuit means generates a plurality of difference measurements; and said circuit means generates signals indicating values of said systolic pressure and said diastolic pressure based on said difference measurements.
Claim 3
Dependent Claim 62 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means generates said signals indicating a value of said systolic pressure substantially near the time of occurrence of a blood pressure pulse having a difference measurement indicating that the static cuff pressure occurring near the time of occurrence of said pulse substantially corresponds to said systolic pressure.
Claim 4
Dependent Claim 62 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means generates said signals indicating a value of said diastolic pressure substantially near the time of occurrence of a blood pressure pulse having a difference measurement indicating that the static cuff pressure occurring near the time of occurrence of said pulse substantially corresponds to said diastolic pressure.
Claim 5
Dependent Claim 36 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means generates said signals indicating a value of said systolic pressure prior to the time of occurrence of said diastolic pressure.
Claim 6
Dependent Claim 33 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means is further responsive to said analog signals for generating signals indicating the value of mean arterial pressure.
Claim 7
Dependent Claim 46 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means comprises means for periodically sampling said analog signals, in the absence of the occurrence of a blood pressure pulse, and for generating signals indicating values of said static cuff pressure.
Claim 8
Dependent Claim 36 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means comprises means for detecting the occurrence of a blood pressure pulse having an amplitude greater than a reference threshold value.
Claim 9
Dependent Claim 53 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means generates said signals indicating the values of said systolic pressure and said diastolic pressure based on magnitudes of difference measurements of blood pressure pulses relative to magnitudes of difference measurements of immediately previously occurring blood pressure pulses.
Claim 10
Dependent Claim 54 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means generates said signals indicating a value for said systolic pressure on the basis of an identification of the occurrence of a valid group of blood pressure pulses when a predetermined number of successive difference measurements increase in magnitude.
Claim 11
Dependent Claim 54 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means generates said signals indicating a value for said diastolic pressure on the basis of an identification of the occurrence of a valid group of blood pressure pulses when a predetermined number of successive difference measurements decrease in magnitude.
Claim 12
Dependent Claim 41 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means comprises pulse detection means responsive to said first analog signal for generating a pulse detection signal indicative of the occurrence of a blood pressure pulse.
Claim 13
Dependent Claim 49 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means comprises peak detection means responsive to said first analog signal for generating, for each of said blood pressure pulses, a peak detection signal indicative of a peak amplitude of each of said pulses.
Claim 14
Dependent Claim 48 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means comprises pulse integration means responsive to said first analog signal for generating, for each of said blood pressure pulses, a pulse integral signal indicative of an integral of each of said pulses.
Claim 15
Dependent Claim 140 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means comprises: pulse detection means responsive to said first analog signal for generating a pulse detection signal indicative of the occurrence of a blood pressure pulse; peak detection means responsive to said first analog signal for generating a peak detection signal indicative of the peak amplitude of said blood pressure pulse; pulse integration means responsive to said first analog signal for generating a pulse integral signal indicative of the integral of said pulse; and differencing means responsive to said peak amplitude signal and to said pulse integral signal for generating, for each blood pressure pulse detected by said pulse detection means, said difference measurement, wherein said difference measurement represents a value of said peak amplitude signal subtracted from the value of said pulse integral signal.
Claim 16
Dependent Claim 45 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means comprises analog-to-digital conversion means for converting said peak amplitude signal into a digital peak amplitude signal, and for converting said pulse integral signal into a digital pulse integral signal.
Claim 17
Dependent Claim 64 words
An oscillometric blood pressure device in accordance with claim 14 characterized in that said circuit means further comprises means for periodically sampling said analog signals, in the absence of the occurrence of a blood pressure pulse, and for storing a signal representative of the most recent sample of said analog signals occurring prior to the time of the occurrence of a blood pressure pulse.
Claim 18
Dependent Claim 46 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said circuit means comprises: first filter means responsive to said analog pressure signals for filtering said first analog signal and for generating only said second analog signal representative of said static cuff pressure.
Claim 19
Dependent Claim 46 words
An oscillometric blood pressure device in accordance with claim 17 characterized in that said circuit means further comprises a differencing circuit responsive to said analog pressure signals for subtracting said second analog signal from said analog pressure signals, and for generating only said first analog signal.
Claim 20
Dependent Claim 46 words
An oscillometric blood pressure device in accordance with claim 1 characterized in that said device further comprises display means responsive to said signals indicating values of said systolic pressure and said diastolic pressure for providing a visual display of said systolic pressure and said diastolic pressure.
Claim 21
Dependent Claim 305 words
An oscillometric blood pressure device for measuring systolic and diastolic blood pressures, and adapted to be interconnected to a cuff attachable to a test subject, said blood pressure device comprising: means adapted to be coupled to said cuff for applying an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; means adapted to be coupled to said cuff for decreasing said occluding pressure to a pressure below said diastolic pressure; a pressure transducer adapted to be coupled to said cuff for generating analog pressure signals representative of instantaneous cuff pressure, said analog pressure signals comprising a first analog signal representative of blood pressure pulses occurring in said artery, and a second analog signal representative of static cuff pressure; an analog pulse detection circuit responsive to said first analog signal for generating an analog pulse detection output signal having a first state indicative of the occurrence of a pulse and a second state indicative of the absence of a pulse; an analog peak detection circuit responsive to said first analog signal for generating an analog peak amplitude signal representative of the maximum amplitude of each pulse; an analog integrator circuit responsive to said first analog signal for generating an analog integral signal representative of the integral of each pulse; circuit means responsive to said analog pulse detector output signal, said analog peak amplitude signal and said analog integral signal for generating, for each of said blood pressure pulses, a difference measurement indicative of the difference between a peak amplitude of a pulse and an integral of said pulse, so that for a plurality of said blood pressure pulses, said circuit means generates a plurality of difference measurements; and said circuit means generates signals indicating values of said systolic pressure and said diastolic pressure based on said difference measurements.
Claim 22
Dependent Claim 305 words
An oscillometric blood pressure device for measuring systolic and diastolic blood pressures, and adapted to be interconnected to a cuff attachable to a test subject, said blood pressure device comprising: means adapted to be coupled to said cuff for applying an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; means adapted to be coupled to said cuff for decreasing said occluding pressure to a pressure below said diastolic pressure; a pressure transducer adapted to be coupled to said cuff for generating analog pressure signals representative of instantaneous cuff pressure, said analog pressure signals comprising a first analog signal representative of blood pressure pulses occurring in said artery, and a second analog signal representative of static cuff pressure; an analog pulse detection circuit responsive to said first analog signal for generating an analog pulse detection output signal having a first state indicative of the occurrence of a pulse and a second state indicative of the absence of a pulse; an analog peak detection circuit responsive to said first analog signal for generating an analog peak amplitude signal representative of the maximum amplitude of each pulse; an analog integrator circuit responsive to said first analog signal for generating an analog integral signal representative of the integral of each pulse; circuit means responsive to said analog pulse detector output signal, said analog peak amplitude signal and said analog integral signal for generating, for each of said blood pressure pulses, a difference measurement indicative of the difference between a peak amplitude of a pulse and an integral of said pulse, so that for a plurality of said blood pressure pulses, said circuit means generates a plurality of difference measurements; and said circuit means generates signals indicating values of said systolic pressure and said diastolic pressure based on said difference measurements.
Claim 23
Dependent Claim 34 words
An oscillometric blood pressure device in accordance with claim 20 characterized in that said signals indicating values of said systolic pressure are generated when a predetermined number of successive difference measurements increase in amplitude.
Claim 24
Dependent Claim 34 words
An oscillometric blood pressure device in accordance with claim 20 characterized in that said signals indicating values of said diastolic pressure are generated when a predetermined number of successive difference measurements decrease in amplitude.
Claim 25
Dependent Claim 46 words
An oscillometric blood pressure device in accordance with claim 20 characterized in that said circuit means comprises conversion means for converting said analog peak amplitude signal into a digital peak amplitude signal, and for converting said analog pulse integral signal into a digital pulse integral signal.
Claim 26
Dependent Claim 61 words
An oscillometric blood pressure device in accordance with claim 23 characterized in that said circuit means further comprises: processing means responsive to said digital peak amplitude signal and to said digital pulse integral signal for generating, for each of said blood pressure pulses, digital signals representative of the difference between said digital peak amplitude signal and said digital pulse integral signal.
Claim 27
Dependent Claim 485 words
An oscillometric blood pressure device for measuring systolic and diastolic blood pressures, and adapted to be interconnected to a cuff attachable to a test subject, said blood pressure device comprising: pump means adapted to be coupled to said cuff for applying an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; bleed means adapted to be coupled to said cuff for decreasing said occluding pressure to a pressure below said diastolic pressure; transducer means coupled to said cuff for generating an analog pressure signals representative of instantaneous cuff pressure, said analog pressure signal comprising a first analog signal representative of blood pressure pulses occurring in said artery and a second analog signal representative of static cuff pressure; first filter means responsive to said analog pressure signal for filtering said analog pressure signal and generating only said second analog signal; differencing circuit means responsive to said analog pressure signal and said second analog signal generated by said filter means for generating an output signal comprising said first analog signal superimposed on a DC level signal; second filter means responsive to said output signal from said differencing circuit means for removing said DC component and for generating only said first analog signal; reference threshold means for generating a reference threshold signal; pulse detector means responsive to said first analog signal and said reference threshold single for generating a pulse detection signal having a first state when said first analog signal is greater than said reference threshold signal, and a second state when said first analog signal is less than said reference threshold signal; reset control means responsive to said pulse detector means for generating a reset signal depending on the state of said pulse detector signal; integrator means responsive to said first analog signal and to said reset signal for integrating said first analog signal during the occurrence of a pulse; peak detector means responsive to said first analog signal and to said reset signal for generating a peak amplitude signal indicative of the peak amplitude occurring during a pulse; processing means responsive to said pulse detector signal for generating control signals; sampling means responsive to said peak detector signal, said integrator signal, said analog signal and said control signals for selectively generating digital representations of said peak amplitude signal, said integrator signal and said second analog signal; said processor means is responsive to said digital representations of said peak detector signal, said integrator signal and said second analog signal for generating, for each of said blood pressure pulses, a difference measurement indicative of the difference between a peak amplitude of a pulse and the integral of said pulse, so that for a plurality of said blood pressure pulses, said circuit means generates a plurality of difference measurements; and said processing means generates signals indicating values of said systolic pressure and said diastolic pressure based on said difference measurements.
Claim 28
Dependent Claim 485 words
An oscillometric blood pressure device for measuring systolic and diastolic blood pressures, and adapted to be interconnected to a cuff attachable to a test subject, said blood pressure device comprising: pump means adapted to be coupled to said cuff for applying an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; bleed means adapted to be coupled to said cuff for decreasing said occluding pressure to a pressure below said diastolic pressure; transducer means coupled to said cuff for generating an analog pressure signals representative of instantaneous cuff pressure, said analog pressure signal comprising a first analog signal representative of blood pressure pulses occurring in said artery and a second analog signal representative of static cuff pressure; first filter means responsive to said analog pressure signal for filtering said analog pressure signal and generating only said second analog signal; differencing circuit means responsive to said analog pressure signal and said second analog signal generated by said filter means for generating an output signal comprising said first analog signal superimposed on a DC level signal; second filter means responsive to said output signal from said differencing circuit means for removing said DC component and for generating only said first analog signal; reference threshold means for generating a reference threshold signal; pulse detector means responsive to said first analog signal and said reference threshold single for generating a pulse detection signal having a first state when said first analog signal is greater than said reference threshold signal, and a second state when said first analog signal is less than said reference threshold signal; reset control means responsive to said pulse detector means for generating a reset signal depending on the state of said pulse detector signal; integrator means responsive to said first analog signal and to said reset signal for integrating said first analog signal during the occurrence of a pulse; peak detector means responsive to said first analog signal and to said reset signal for generating a peak amplitude signal indicative of the peak amplitude occurring during a pulse; processing means responsive to said pulse detector signal for generating control signals; sampling means responsive to said peak detector signal, said integrator signal, said analog signal and said control signals for selectively generating digital representations of said peak amplitude signal, said integrator signal and said second analog signal; said processor means is responsive to said digital representations of said peak detector signal, said integrator signal and said second analog signal for generating, for each of said blood pressure pulses, a difference measurement indicative of the difference between a peak amplitude of a pulse and the integral of said pulse, so that for a plurality of said blood pressure pulses, said circuit means generates a plurality of difference measurements; and said processing means generates signals indicating values of said systolic pressure and said diastolic pressure based on said difference measurements.
Claim 29
Dependent Claim 206 words
An oscillometric device having means to detected the occurrence of pulses in an analog electrical signal, means for generating pulse characteristic signals representative of predetermined characteristics of said pulses, and means for analyzing characteristics of said pulses and for generating indicating signals on the basis of said analysis of said pulse characteristics, the improvement comprising: filter means responsive to said analog signal for filtering said analog signal and for generating a filtered analog signal representative only of said pulses, wherein said pulse characteristics generating means is responsive to said filtered analog signal for generating analog pulse characteristic signals representative of predetermined characteristics of each of said pulses, said pulse characteristic signals each having a steady state value substantially at the time of occurrence of the end of a pulse; and said analyzing means comprises means responsive to said detection means detecting the end of a pulse for sampling, only once for each detected pulse, each of said pulse characteristic signals and for generating said indicating signals on the basis of an analysis of said sampled pulse characteristic signals, so that said indicating signals can be generated without requiring any periodic sampling of said pulse characteristic signals or said filtered analog signal during the occurrence of pulses.
Claim 30
Dependent Claim 206 words
An oscillometric device having means to detected the occurrence of pulses in an analog electrical signal, means for generating pulse characteristic signals representative of predetermined characteristics of said pulses, and means for analyzing characteristics of said pulses and for generating indicating signals on the basis of said analysis of said pulse characteristics, the improvement comprising: filter means responsive to said analog signal for filtering said analog signal and for generating a filtered analog signal representative only of said pulses, wherein said pulse characteristics generating means is responsive to said filtered analog signal for generating analog pulse characteristic signals representative of predetermined characteristics of each of said pulses, said pulse characteristic signals each having a steady state value substantially at the time of occurrence of the end of a pulse; and said analyzing means comprises means responsive to said detection means detecting the end of a pulse for sampling, only once for each detected pulse, each of said pulse characteristic signals and for generating said indicating signals on the basis of an analysis of said sampled pulse characteristic signals, so that said indicating signals can be generated without requiring any periodic sampling of said pulse characteristic signals or said filtered analog signal during the occurrence of pulses.
Claim 31
Dependent Claim 307 words
An oscillometric blood pressure device for measuring systolic and diastolic blood pressures, and adapted to be interconnected to a cuff attachable to a test subject, said blood pressure device comprising: means adapted to be coupled to said cuff for applying an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; means adapted to be coupled to said cuff for decreasing said occluding pressure to a pressure below said diastolic pressure; a pressure transducer adapted to be coupled to said cuff for generating analog pressure signals representative of instantaneous cuff pressure, said analog pressure signals comprising a first analog signal representative of blood pressure pulses occurring in said artery, and a second analog signal representative of static cuff pressure; filter means responsive to said analog pressure signals for filtering said analog pressure signals and for generating a filtered analog signal comprising said first analog signal; pulse characteristic generating means responsive to said filtered analog signal for generating analog pulse characteristic signals representative of predetermined characteristics of each of said pulses, said pulse characteristic signals each having a steady state value substantially at the time of occurrence of the end of a pulse; pulse detection means responsive to said filtered analog signal for detecting the occurrence of a pulse, including the end of a pulse; and analyzing means responsive to said detection means detecting the end of a pulse for sampling, only once for each detected pulse, each of said pulse characteristic signals and for generating indicating signals on the basis of an analysis of said sampled pulse characteristic signals, said indicating signals indicating the occurrence or non-occurrence of said systolic and diastolic blood pressures, wherein said indicating signals are generated without requiring any periodic sampling of said pulse characteristic signals or said filtered analog signal during the occurrence of pulses.
Claim 32
Dependent Claim 307 words
An oscillometric blood pressure device for measuring systolic and diastolic blood pressures, and adapted to be interconnected to a cuff attachable to a test subject, said blood pressure device comprising: means adapted to be coupled to said cuff for applying an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; means adapted to be coupled to said cuff for decreasing said occluding pressure to a pressure below said diastolic pressure; a pressure transducer adapted to be coupled to said cuff for generating analog pressure signals representative of instantaneous cuff pressure, said analog pressure signals comprising a first analog signal representative of blood pressure pulses occurring in said artery, and a second analog signal representative of static cuff pressure; filter means responsive to said analog pressure signals for filtering said analog pressure signals and for generating a filtered analog signal comprising said first analog signal; pulse characteristic generating means responsive to said filtered analog signal for generating analog pulse characteristic signals representative of predetermined characteristics of each of said pulses, said pulse characteristic signals each having a steady state value substantially at the time of occurrence of the end of a pulse; pulse detection means responsive to said filtered analog signal for detecting the occurrence of a pulse, including the end of a pulse; and analyzing means responsive to said detection means detecting the end of a pulse for sampling, only once for each detected pulse, each of said pulse characteristic signals and for generating indicating signals on the basis of an analysis of said sampled pulse characteristic signals, said indicating signals indicating the occurrence or non-occurrence of said systolic and diastolic blood pressures, wherein said indicating signals are generated without requiring any periodic sampling of said pulse characteristic signals or said filtered analog signal during the occurrence of pulses.
Claim 33
Independent Claim 165 words
A method adapted for use with an oscillometric blood pressure device for measuring systolic and diastolic blood pressures, said method comprising the steps of: applying to a cuff attachable to a test subject an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; gradually decreasing said occluding pressure; generating analog pressure signals representative of instantaneous cuff pressure, with said analog pressure signals comprising a first analog signal representative of blood pressure pulses occurring in said artery and a second analog signal representative of static cuff pressure; generating, for each of said blood pressure pulses, and in response to said first analog signal, a difference measurement indicative of the difference between a peak amplitude of a pulse and an integral of said pulse, so that for a plurality of said blood pressure pulses, a plurality of difference measurements are generated; and generating signals indicating values of said systolic pressure and said diastolic pressure based on said difference measurements.
Claim 34
Independent Claim 165 words
A method adapted for use with an oscillometric blood pressure device for measuring systolic and diastolic blood pressures, said method comprising the steps of: applying to a cuff attachable to a test subject an occluding pressure greater than said systolic pressure in the vicinity of an artery of said test subject; gradually decreasing said occluding pressure; generating analog pressure signals representative of instantaneous cuff pressure, with said analog pressure signals comprising a first analog signal representative of blood pressure pulses occurring in said artery and a second analog signal representative of static cuff pressure; generating, for each of said blood pressure pulses, and in response to said first analog signal, a difference measurement indicative of the difference between a peak amplitude of a pulse and an integral of said pulse, so that for a plurality of said blood pressure pulses, a plurality of difference measurements are generated; and generating signals indicating values of said systolic pressure and said diastolic pressure based on said difference measurements.
Claim 35
Dependent Claim 58 words
A method in accordance with claim 28, further comprising the step of generating said signals indicating a value of said systolic pressure substantially near the time of occurrence of a blood pressure pulse having a difference measurement indicating that the static cuff pressure occurring near the time of occurrence of said pulse substantially corresponds to said systolic pressure.
Claim 36
Dependent Claim 63 words
A method in accordance with claim 28, characterized in that said method further comprises the step of generating said signals indicating a value of said diastolic pressure substantially near the time of occurrence of a blood pressure pulse having a difference measurement indicating that the static cuff pressure occurring near the time of occurrence of said pulse substantially corresponds to said diastolic pressure.
Claim 37
Dependent Claim 32 words
A method in accordance with claim 28 characterized in that said method further comprises the step of generating, in response to said analog signals, signals indicating the value of mean arterial pressure.
Claim 38
Dependent Claim 43 words
A method in accordance with claim 28 characterized in that said method further comprises the step of periodically sampling said analog signals, in the absence of the occurrence of a blood pressure pulse, and generating signals indicating values of said static cuff pressure.
Claim 39
Dependent Claim 53 words
A method in accordance with claim 28 characterized in that said method further comprises the step of generating said signals indicating values of said systolic pressure and said diastolic pressure based on magnitudes of difference measurements of blood pressure pulses relative to magnitudes of difference measurements of immediately previously occurring blood pressure pulses.

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