US4137907A
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Systolic pressure determining apparatus and process using integration to determine pulse amplitude
Assignee: Baxter International Inc
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Filing: 1976-12-27
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Granted: 1979-02-06
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Expires: 1996-12-27
Abstract
Abstract Improved method and apparatus for identifying and quantizing a substantially periodic, steeply rising wavefront of a signal in the possible presence of low amplitude interference. A time derivative of at least the steep wavefront is obtained. The derivative is then integrated over a predetermined interval in each of successive repetitions of the steep wavefront, the interval being that during which the derivative exceeds a reference level. A threshold value is established, preferably dynamically, to verify or validate that when the derivative exceeds the reference level it indeed represents the steeply rising wavefront. The integrated derivative is recognized as the quantized value of the steeply rising wavefront only if such verification occurs. The invention is suited to oscillometric determination of systolic pressure in a patient, where measurement of signal amplitude is preferably achieved by integrating the time derivative of the systolic rise wavefront.
Inventors
- 👤 William D. Jansen
- 👤 Jerry D. Haney
- 👤 Christopher C. Day
- 👤 Stephen A. Schneeberger
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:09
CPC Classifications
A; A61; A61B; A61B5/00; A61B5/02; A61B5/021; A61B5/022; A61B5/02225; A61B5/02108; A61B5/02116; A61B5/72; A61B5/7235; A61B5/7239; A61B5/7242
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
337 words
Apparatus for determining systolic pressure of a living test subject comprising means for applying a selectively changeable pressure to the test subject adjacent a blood vessel; means for measuring a fluctuating quantity proportional to a sum, said sum comprising a time-dependent fluctuating component proportional to the amplitude of the pulsatile pressure within the blood vessel plus the selectively changeable pressure applied externally adjacent the blood vessel; means for converting said quantity into a representation of a time derivative of said fluctuating component thereof; means for obtaining the time integral of said time derivative over an interval of predetermined limits in each of successive blood pressure pulses, said interval being the time during which said time derivative representation exceeds a predetermined reference level; means for determining the maximum value attained by successive said integrals as the applied pressure is changed; means for storing a representation of said maximum integral value; means for determining when a said integral is substantially equal to a predetermined fraction of said maximum integral value for an applied pressure greater than the pressure applied when said maximum integral value results; means for reading out said applied pressure corresponding to said integral being substantially equal to said predetermined fraction to said maximum value, said read-out pressure corresponding to the systolic pressure of said subject; means for establishing a threshold level signal representative of the magnitude of substantially only the time derivative representing a systolic rise; means for comparing said time derivative representation of said fluctuating component of said quantity with said threshold level signal while said time derivative representation exceeds said reference level to provide a control signal indicative of whether or not said time derivative representation exceeding said reference level is representative of a valid systolic rise; and means responsive only to a validating indication that a particular said time derivative representation exceeding said reference level is a systolic rise for extending said integral of said particular representation to said maximum integral value determining means and said fraction of maximum integral value determining means.
Claim 2
Dependent Claim
337 words
Apparatus for determining systolic pressure of a living test subject comprising means for applying a selectively changeable pressure to the test subject adjacent a blood vessel; means for measuring a fluctuating quantity proportional to a sum, said sum comprising a time-dependent fluctuating component proportional to the amplitude of the pulsatile pressure within the blood vessel plus the selectively changeable pressure applied externally adjacent the blood vessel; means for converting said quantity into a representation of a time derivative of said fluctuating component thereof; means for obtaining the time integral of said time derivative over an interval of predetermined limits in each of successive blood pressure pulses, said interval being the time during which said time derivative representation exceeds a predetermined reference level; means for determining the maximum value attained by successive said integrals as the applied pressure is changed; means for storing a representation of said maximum integral value; means for determining when a said integral is substantially equal to a predetermined fraction of said maximum integral value for an applied pressure greater than the pressure applied when said maximum integral value results; means for reading out said applied pressure corresponding to said integral being substantially equal to said predetermined fraction to said maximum value, said read-out pressure corresponding to the systolic pressure of said subject; means for establishing a threshold level signal representative of the magnitude of substantially only the time derivative representing a systolic rise; means for comparing said time derivative representation of said fluctuating component of said quantity with said threshold level signal while said time derivative representation exceeds said reference level to provide a control signal indicative of whether or not said time derivative representation exceeding said reference level is representative of a valid systolic rise; and means responsive only to a validating indication that a particular said time derivative representation exceeding said reference level is a systolic rise for extending said integral of said particular representation to said maximum integral value determining means and said fraction of maximum integral value determining means.
Claim 3
Dependent Claim
76 words
The apparatus of claim 1 wherein said input signal is additionally in the possible presence of high amplitude, low frequency interference and wherein said time derivative means comprises a differentiating network for converting said input signal into a representation of the first time derivative thereof over a frequency band including said steeply rising wavefront and into a representation of the second time derivative thereof at the lower frequency of said possible high amplitude, low frequency interference.
Claim 4
Dependent Claim
40 words
The apparatus of claim 1 wherein said threshold level signal establishing means establishes said threshold level as a function of the magnitude by which at least the immediately preceding time derivative representation exceeding said reference level exceeds another reference level.
Claim 5
Dependent Claim
17 words
The apparatus of claim 3 wherein said reference level and said other reference level are the same.
Claim 6
Dependent Claim
27 words
The apparatus of claim 4 wherein said threshold level is proportional only to the magnitude by which said immediately preceding time derivative representation exceeds said reference level.
Claim 7
Dependent Claim
23 words
The apparatus of claim 5 wherein said threshold level is substantially 50% of said reference-exceeding magnitude of said immediately preceding time derivative representation.
Claim 8
Dependent Claim
91 words
The apparatus of claim 6 wherein said means for obtaining the time integral of said time derivative representation comprises accumulating means, said time derivative representation being subdivided into successive subinterval increments applied to and accumulated in said accumulating means during each interval in which it exceeds said reference level, the accumulated value of said subinterval increments for each said reference-level-exceeding interval comprising a respective tentative said integral, said systolic rise validating means being operative to extend only said integrals attending respective valid systolic rises to said maximum integral value determining means.
Claim 9
Dependent Claim
167 words
The apparatus of claim 6 wherein said means for obtaining the time integral of said time derivative representation comprises accumulating means, means for temporarily storing that portion of said time derivative representation extending over an immediately preceding interval, said immediately preceding interval being at least as long as the maximum anticipated duration of the systolic rise portion of the blood pressure pulses, means responsive to said time derivative representation going from a level exceeding said reference level to a level not exceeding said reference level and responsive to an indication of valid systolic rise from said validating means for directing a last in-first out readout of said portion of said time derivative representation stored in said storage means, means for extending said readout from said storage means to said accumulating means and for accumulating only those values of said readout which exceed said reference level, the value of said time derivative representation readout accumulated by said accumulating means being extended to said maximum integral value determining means.
Claim 10
Dependent Claim
82 words
The apparatus of claim 1 wherein said means for obtaining the time integral of said time derivative representation comprises accumulating means, said time derivative representation being applied to and accumulated in said accumulating means during each interval in which it exceeds said reference level, the accumulated value of each said reference-level-exceeding intervals comprising a respective tentative said integral, said systolic rise validating means being operative to extend only said integrals attending respective valid systolic rises to said maximum integral value determining means.
Claim 11
Dependent Claim
18 words
The apparatus of claim 9 including means for clearing said accumulating means prior to each subsequent integrating accumulation.
Claim 12
Dependent Claim
39 words
The apparatus of claim 9 including means for converting at least said reference-level-exceeding portions of said time derivative representation to consecutively timed discrete increments thereof and wherein said accumulating means sum said discrete increments which exceed said reference level.
Claim 13
Dependent Claim
167 words
The apparatus of claim 1 wherein said means for obtaining the time integral of said time derivative representation comprises accumulating means, means for temporarily storing that portion of said time derivative representation extending over an immediately preceding interval, said immediately preceding interval being at least as long as the maximum anticipated duration of the systolic rise portion of the blood pressure pulses, means responsive to said time derivative representation going from a level exceeding said reference level to a level not exceeding said reference level and responsive to an indication of valid systolic rise from said validating means for directing a last in-first out readout of said portion of said time derivative representation stored in said storage means, means for extending said readout from said storage means to said accumulating means and for accumulating only those values of said readout which exceed said reference level, the value of said time derivative representation readout accumulated by said accumulating means being extended to said maximum integral value determining means.
Claim 14
Dependent Claim
18 words
The apparatus of claim 12 including means for clearing said accumulating means prior to each subsequent integrating accumulation.
Claim 15
Independent Claim
245 words
A method for determining blood pressure of a living test subject comprising: applying a selectively changeable pressure to the test subject adjacent a blood vessel; measuring a quantity proportional to a sum, the sum comprising a time-dependent fluctuating component proportional to the amplitude of the pulsatile pressure within the blood vessel plus the selectively changeable pressure applied externally adjacent the blood vessel; converting said quantity into a representation of the time derivative of the fluctuating component thereof, a portion of the time derivative in each of successive blood pressure pulses being representative of the systolic rise; determining the time integral of said time derivative over an interval of predetermined limits in each of successive blood pressure pulses as a measure of this systolic rise, said interval being the time during which said time derivative representation exceeds a predetermined reference level; establishing a threshold level signal representative of the magnitude of substantially only the time derivative representation of a systolic rise; comparing said time derivative representation of said fluctuating component of said quantity with said threshold level signal while the time derivative representation exceeds said reference level to provide a control signal indicative of whether or not said time derivative representation exceeding said reference level is representative of a valid systolic rise; processing selective ones of said time integral to provide an indication of blood pressure; and selecting for processing only the said time interval of said time derivative representations indicated as being valid systolic rises.
Claim 16
Independent Claim
245 words
A method for determining blood pressure of a living test subject comprising: applying a selectively changeable pressure to the test subject adjacent a blood vessel; measuring a quantity proportional to a sum, the sum comprising a time-dependent fluctuating component proportional to the amplitude of the pulsatile pressure within the blood vessel plus the selectively changeable pressure applied externally adjacent the blood vessel; converting said quantity into a representation of the time derivative of the fluctuating component thereof, a portion of the time derivative in each of successive blood pressure pulses being representative of the systolic rise; determining the time integral of said time derivative over an interval of predetermined limits in each of successive blood pressure pulses as a measure of this systolic rise, said interval being the time during which said time derivative representation exceeds a predetermined reference level; establishing a threshold level signal representative of the magnitude of substantially only the time derivative representation of a systolic rise; comparing said time derivative representation of said fluctuating component of said quantity with said threshold level signal while the time derivative representation exceeds said reference level to provide a control signal indicative of whether or not said time derivative representation exceeding said reference level is representative of a valid systolic rise; processing selective ones of said time integral to provide an indication of blood pressure; and selecting for processing only the said time interval of said time derivative representations indicated as being valid systolic rises.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-05 | 1982-08-07 | 1983-02-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-05 | 1986-08-07 | 1987-02-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-05 | 1990-08-07 | 1991-02-06 | $7700.00 | Window Closed / Lapsed |