Patent US5028599A successfully refreshed from Google Patents.
US5028599A
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Method of treating mycardial damage
Assignee: Emory University
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Filing: 1990-05-11
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Granted: 1991-07-02
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Expires: 2010-05-11
Abstract
Abstract In accordance with the present invention, a method is provided for treating myocardial damage. More particularly, the present invention relates to a method for treating myocardial damage comprising injecting certain ethylene oxide-propylene oxide condensation surface-active copolymers. The surface-active copolymer can be an ethylene oxide-propylene oxide condensation product with the following general formula: HO(C2H4O)b(C3H6O)a(C2H4O)bH wherein a is an integer such that the hydrophobe represented by (C3H6O) has a molecular weight of approximately 950 to 4000, preferably approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C2H4O) constitutes approximately 50% to 90% by weight of the compound.
Inventors
- 👤 Robert L. Hunter
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/74; A61K31/765; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126; A61K38/00; A61K38/16; A61K38/164; A61K38/166; A61K38/43; A61K38/44; A61K38/446; A61K38/46; A61K38/48; A61K38/49
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
104 words
A method for treating myocardial damage in a human or animal comprising the step of injecting into the human or animal with the myocardial damage a solution with an effective concentration of a surface-active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 2
Independent Claim
104 words
A method for treating myocardial damage in a human or animal comprising the step of injecting into the human or animal with the myocardial damage a solution with an effective concentration of a surface-active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 3
Dependent Claim
77 words
The method of claim 1 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 4
Dependent Claim
49 words
The method of claim 1 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 5
Dependent Claim
15 words
The method of claim 1, wherein the myocardial damage is caused by a myocardial infarction.
Claim 6
Independent Claim
105 words
A method for treating myocardial damage in a human or animal comprising the step of injecting intravenously into the human or animal with the myocardial damage a solution with an effective concentration of a surface-active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 7
Independent Claim
105 words
A method for treating myocardial damage in a human or animal comprising the step of injecting intravenously into the human or animal with the myocardial damage a solution with an effective concentration of a surface-active copolymer with the following general formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 8
Dependent Claim
77 words
The method of claim 5 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 9
Dependent Claim
49 words
The method of claim 5 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 10
Dependent Claim
15 words
The method of claim 5 wherein the myocardial damage is caused by a myocardial infarction.
Claim 11
Independent Claim
104 words
A method for treating myocardial damage in a human or animal comprising the step of injecting intramuscularly into the human or animal with the myocardial damage a solution with an effective concentration of a surface-active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 12
Independent Claim
104 words
A method for treating myocardial damage in a human or animal comprising the step of injecting intramuscularly into the human or animal with the myocardial damage a solution with an effective concentration of a surface-active copolymer with the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 950 to 4000, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 13
Dependent Claim
77 words
The method of claim 9 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein a is an integer such that the hydrophobe represented by (C 3 H 6 O) has a molecular weight of between approximately 1200 to 3500, and b is an integer such that the hydrophile portion represented by (C 2 H 4 O) constitutes between approximately 50% to 90% by weight of the copolymer.
Claim 14
Dependent Claim
49 words
The method of claim 9 wherein the surface-active copolymer has the following formula: HO(C.sub.2 H.sub.4 O).sub.b (C.sub.3 H.sub.6 O).sub.a (C.sub.2 H.sub.4 O).sub.b H wherein the molecular weight of the hydrophobe (C 3 H 6 O) is approximately 1750 and the total molecular weight of the compound is approximately 8400.
Claim 15
Dependent Claim
15 words
The method of claim 9, wherein the myocardial damage is caused by a myocardial infarction.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1994-07-01 | 1994-12-31 | 1995-07-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-07-01 | 1998-12-31 | 1999-07-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-07-01 | 2002-12-31 | 2003-07-02 | $7700.00 | Window Closed / Lapsed |