US4186253A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Perfusate for preserving organ to be transplanted and preserving method
Assignee: Tanabe Pharma Corp
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Filing: 1978-10-10
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Granted: 1980-01-29
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Expires: 1998-10-10
Abstract
Abstract An organ to be transplanted, such as kidney, can effectively be preserved by perfusion for a considerably long time by the use of a perfusate which is made by mixing a Ringer's solution modified by increasing potassium ion to 8-20 meq/l, a stable perfluorocarbon compound emulsion and albumin, so that the concentration of the perfluorocarbon compound is 7.5 to 12.5% (W/V) and that of albumin is 1-8% (W/V) based on the perfusate.
Inventors
- 👤 Kazumasa Yokoyama
- 👤 Masakazu Iwai
- 👤 Hiroyuki Okamoto
- 👤 Noboru Yamada
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:20
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/126
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
45 words
A liquid for the perfusional preservation of an organ for transplantation, comprising a modified Ringer's solution characterized by containing potassium ion in a concentration of 8 to 20 meq/liter, and effective amounts of albumin dissolved therein, a liquid perfluorocarbon compound emulsified therein, and an emulsifier.
Claim 2
Dependent Claim
45 words
A liquid for the perfusional preservation of an organ for transplantation, comprising a modified Ringer's solution characterized by containing potassium ion in a concentration of 8 to 20 meq/liter, and effective amounts of albumin dissolved therein, a liquid perfluorocarbon compound emulsified therein, and an emulsifier.
Claim 3
Dependent Claim
15 words
The liquid of claim 1 which contains the albumin in concentrations of 1 to 8%(W/V).
Claim 4
Dependent Claim
17 words
The liquid of claim 1 which contains the perfluorocarbon compound in a concentration of 7.5 to 12.5%(W/V).
Claim 5
Dependent Claim
15 words
The liquid of claim 1, wherein the perfluorocarbon compound has 9 to 12 carbon atoms.
Claim 6
Dependent Claim
81 words
The liquid of claim 4, wherein the perfluorocarbon compound is at least one member selected from the group consisting of perfluoroalkylcyclohexane having 3 to 5 carbon atoms in the alkyl, perfluorodecalin, perfluoro methyldecalin, perfluoroalkyltetrahydropyran having 4 to 6 carbon atoms in the alkyl, perfluoro alkyltetrahydrofuran having 5 to 7 carbon atoms in the alkyl, perfluoro alkylpiperidine having 4 to 6 carbon atoms in the alkyl, perfluoro alkylmorpholine having 5 to 7 carbon atoms in the alkyl, perfluoro trialkylamine, perfluoro(diethylcyclohexylamine), and perfluoro(dioxaalkane).
Claim 7
Dependent Claim
25 words
The liquid of claim 4, wherein the perfluorocarbon compound is perfluoro alkylcyclohexane having 3 to 5 carbon atoms in the alkyl, perfluorodecalin or perfluoro methyldecalin.
Claim 8
Dependent Claim
55 words
The liquid of claim 4, wherein the perfluorocarbon compound is perfluoro alkyltetrahydropyran having 4 to 6 carbon atoms in the alkyl, perfluoro alkyltetrahydrofuran having 5 to 7 carbon atoms in the alkyl, perfluoro alkylpiperidine having 4 to 6 carbon atoms in the alkyl, or perfluoro alkylmorpholine having 5 to 7 carbon atoms in the alkyl.
Claim 9
Dependent Claim
13 words
The liquid of claim 4, wherein the perfluorocycloalkane is perfluorodecalin, perfluoro(methyldecalin) or perfluoro(dimethyldecalin).
Claim 10
Dependent Claim
15 words
The liquid of claim 6, wherein the perfluorocycloalkane is perfluoro(butylcyclohexane), perfluoro(methylpropylcyclohexane), perfluoro(trimethylcyclohexane), perfluoro(ethylpropylcyclohexane) or perfluoro(pentylcyclohexane).
Claim 11
Dependent Claim
19 words
The liquid of claim 7, wherein the perfluoro-saturated-heterocyclic compound is perfluoro(butyltetrahydropyran), perfluoro(pentyltetrahydrofuran), perfluoro(hexyltetrahydrofuran), perfluoro(heptyltetrahydrofuran), perfluoro(N-hexylpiperidine), perfluoro(N-pentylmorpholine), perfluoro(N-hexylmorpholine) or perfluoro(N-heptylmorpholine).
Claim 12
Dependent Claim
16 words
The liquid of claim 4, wherein the perfluorocarbon compound is a perfluoro trialkylamine, perfluoro(diethylcyclohexylamine) or perfluoro(dioxaalkane).
Claim 13
Dependent Claim
19 words
The liquid of claim 11, wherein the perfluorocarbon compound is a perfluoro-tert-amine which is perfluoro(diethylhexylamine), perfluoro(dipropylbutylamine), perfluoro(diethylcyclohexylamine) or perfluoro(tributylamine).
Claim 14
Dependent Claim
27 words
The liquid of claim 11, wherein the perfluorocarbon compound is a perfluoro(dioxaalkane) which is perfluoro(tetramethylene glycol diisopropyl ether), perfluoro(trimethylene glycol diisobutyl ether) or perfluoro(isopropylidene glycol di-n-propyl ether).
Claim 15
Dependent Claim
25 words
The liquid of claim 1, wherein the emulsifier is a polyoxyethylene-polyoxypropylene copolymer, polyoxyethylene alkyl ether, polyoxyalkyl allyl ether or a phospholipid or a mixture thereof.
Claim 16
Dependent Claim
24 words
The liquid of claim 1, wherein a C 8-21 -fatty acid is present together with the emulsifier, said fatty acid being an auxiliary emulsifier.
Claim 17
Dependent Claim
85 words
A process for preserving an organ to be transplanted comprising perfusing the organ with a perfusion liquid containing a perfluorocarbon compound under oxygenation, characterized in that the perfusion liquid is a mixture of effective amounts of albumin, a Ringer's solution which has been modified in the amount of potassium ion by increasing the amount to 8-20meq/liter, and a stable emulsion of a perfluorocarbon emulsion, the concentration of albumin being 1-8%(W/V) and that of the perfluorocarbon compound being 7.5 to 12.5%(W/V) based on the perfusion liquid.
Claim 18
Dependent Claim
85 words
A process for preserving an organ to be transplanted comprising perfusing the organ with a perfusion liquid containing a perfluorocarbon compound under oxygenation, characterized in that the perfusion liquid is a mixture of effective amounts of albumin, a Ringer's solution which has been modified in the amount of potassium ion by increasing the amount to 8-20meq/liter, and a stable emulsion of a perfluorocarbon emulsion, the concentration of albumin being 1-8%(W/V) and that of the perfluorocarbon compound being 7.5 to 12.5%(W/V) based on the perfusion liquid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-28 | 1983-07-30 | 1984-01-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-28 | 1987-07-30 | 1988-01-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-28 | 1991-07-30 | 1992-01-29 | $7700.00 | Window Closed / Lapsed |