US4100271A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes
Assignee: Iolab Corp
•
Filing: 1976-02-26
•
Granted: 1978-07-11
•
Expires: 1996-02-26
Abstract
Abstract Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The pharmaceutical vehicles are clear, water-miscible, physiologically-acceptable, liquid compositions which gel to a thickened, non-flowing and adhering consistency at human body temperature. They are liquid at ambient room temperature and have a gel transition temperature in the range of from about 25° to about 40° C. Aqueous solutions of certain polyoxyethylene-polyoxypropylene condensates are suitable vehicles. Also provided are pharmaceutical compositions containing added pharmacologically active chemical material, i.e., a drug or medicament. A method of delivering the drug or medicament to a mucous membrane is also provided.
Inventors
- 👤 Joseph Z. Krezanoski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 22:21
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/02; A61K9/00; A61K9/0012; A61K9/0048; A61P; A61P27/00; A61P27/02
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
81 words
A method of therapeutically treating the symptoms of Sjogren's syndrome, ophthalmic edema and eye irritation in a mammal, comprising, topically administering to affected eyes of such mammal, a pharmaceutical composition which consists of a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing and adhering consistency at human body temperature, the composition comprising an aqueous solution of a polyoxyethylenepolyoxypropylene block copolymer and having a gel transition temperature in the range of from about 25° to about 40° C.
Claim 2
Independent Claim
81 words
A method of therapeutically treating the symptoms of Sjogren's syndrome, ophthalmic edema and eye irritation in a mammal, comprising, topically administering to affected eyes of such mammal, a pharmaceutical composition which consists of a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing and adhering consistency at human body temperature, the composition comprising an aqueous solution of a polyoxyethylenepolyoxypropylene block copolymer and having a gel transition temperature in the range of from about 25° to about 40° C.
Claim 3
Dependent Claim
20 words
A method according to claim 1 in which the pharmaceutical composition is applied to the affected eyes in drop form.
Claim 4
Dependent Claim
23 words
A method according to claim 1 in which the composition has a pH in the range of from about 6.2 to about 7.8.
Claim 5
Independent Claim
89 words
A method of medicinally treating a mucous membrane condition in need of pharmacologic treatment comprising contacting such mucous membrane with a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing and adhering consistency after contact with the mucous membrane, the liquid composition comprising a pharmacologically effective amount of a chemical material which is pharmacologically active against said condition, and a pharmaceutical vehicle which is a clear, water-miscible, physiologically acceptable liquid having a gel transition temperature in the range of from about 25° to about 40° C.
Claim 6
Independent Claim
89 words
A method of medicinally treating a mucous membrane condition in need of pharmacologic treatment comprising contacting such mucous membrane with a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing and adhering consistency after contact with the mucous membrane, the liquid composition comprising a pharmacologically effective amount of a chemical material which is pharmacologically active against said condition, and a pharmaceutical vehicle which is a clear, water-miscible, physiologically acceptable liquid having a gel transition temperature in the range of from about 25° to about 40° C.
Claim 7
Dependent Claim
23 words
A method according to claim 4 in which the composition has a pH in the range of from about 6.2 to about 7.8.
Claim 8
Dependent Claim
15 words
A method according to claim 4 in which the pharmacologically active chemical material is dexamethasone.
Claim 9
Dependent Claim
16 words
A method according to claim 4 in which the pharmacologically active chemical material is pilocarpine HCl.
Claim 10
Dependent Claim
15 words
A method according to claim 4 in which the pharmacologically active chemical material is phenylephrine.
Claim 11
Dependent Claim
17 words
A method according to claim 4 in which the pharmacologically active chemical material is an antimicrobial agent.
Claim 12
Dependent Claim
33 words
A method according to claim 9 in which the pharmacologically active chemical material is selected from the group consisting of clofazimine, pimaricin, amphotericin, neomycin sulfate, chloramphenicol, bacitracin, sulfacetamide, gentamycin, and polymixin B sulfate.
Claim 13
Dependent Claim
20 words
A method according to claim 4 in which the liquid composition is applied to the mucous membrane in drop form.
Claim 14
Independent Claim
87 words
A method of medicinally treating an eye condition in need of pharmacologic treatment comprising contacting the affected eye with a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing adhering consistency after contact with the mucous membrane, the liquid composition comprising a pharmacologically effective amount of a chemical material which is pharmacologically active against said condition, and a pharmaceutical vehicle which is a clear, water-miscible, physiologically acceptable liquid having a gel transition temperature in the range of from about 25° to about 40° C.
Claim 15
Independent Claim
87 words
A method of medicinally treating an eye condition in need of pharmacologic treatment comprising contacting the affected eye with a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing adhering consistency after contact with the mucous membrane, the liquid composition comprising a pharmacologically effective amount of a chemical material which is pharmacologically active against said condition, and a pharmaceutical vehicle which is a clear, water-miscible, physiologically acceptable liquid having a gel transition temperature in the range of from about 25° to about 40° C.
Claim 16
Dependent Claim
23 words
A method according to claim 12 in which the composition has a pH in the range of from about 6.2 to about 7.8.
Claim 17
Dependent Claim
15 words
A method according to claim 12 in which the pharmacologically active chemical material is dexamethasone.
Claim 18
Dependent Claim
22 words
A method according to claim 12 in which the pharmacologically active chemical material is pilocarpine HCl and the eye condition is glaucoma.
Claim 19
Dependent Claim
15 words
A method according to claim 12 in which the pharmacologically active chemical material is phenylephrine.
Claim 20
Dependent Claim
17 words
A method according to claim 12 in which the pharmacologically active chemical material is an antimicrobial agent.
References Cited (Backward Citations)
US2921885A
Cited
US3240709A
Cited
US3740421A
Cited
US3639574A
Cited
US3882036A
Cited
US3867533A
Cited
US3947573A
Cited
US3767788A
Cited
US3884826A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-07-10 | 1982-01-09 | 1982-07-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-07-10 | 1986-01-09 | 1986-07-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-07-10 | 1990-01-09 | 1990-07-11 | $7700.00 | Window Closed / Lapsed |