Patent US5000962A successfully refreshed from Google Patents.
US5000962A
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US
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Long acting diltiazem formulation
Assignee: Merck Sharp & Dohme LLC
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Filing: 1989-08-25
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Granted: 1991-03-19
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Expires: 2009-08-25
Abstract
Abstract A long acting diltiazem formulation is disclosed that comprises more than 35 percent by weight of a swellable hydrophilic polymer. Release rate is also controlled by the application of diffusion controlled membrane to the matrix tablet containing swellable hydrophilic polymers. The diffusion rate through the membrane depends upon the composition or ratio of hydrophilic to hydrophobic coating agent.
Inventors
- 👤 Surendra Sangekar
- 👤 Winston A. Vadino
- 👤 Eugenio A. Cefali
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 16:55
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; A61K31/00; A61K31/33; A61K31/395; A61K31/55; A61K9/205; A61K9/2054; A61K9/28; A61K9/2806; A61K9/2833; A61K9/286; A61K9/2866
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
42 words
A long acting diltiazem tablet consisting essentially of: (a) 3 to 80 percent diltiazem hydrochloride; (b) 35 to 60 percent hydroxypropylmethyl cellulose; (c) 2 to 6 percent polyvinylpyrrolidone; (d) 0.5 to 3 percent magnesium stearate; and (e) 10 to 50 percent lactose.
Claim 2
Dependent Claim
42 words
A long acting diltiazem tablet consisting essentially of: (a) 3 to 80 percent diltiazem hydrochloride; (b) 35 to 60 percent hydroxypropylmethyl cellulose; (c) 2 to 6 percent polyvinylpyrrolidone; (d) 0.5 to 3 percent magnesium stearate; and (e) 10 to 50 percent lactose.
Claim 3
Dependent Claim
46 words
The long acting diltiazem tablet defined in claim 1 consisting essentially of (a) 3 to 57 percent diltiazem hydrochloride; (b) 35 to 45 percent hydroxypropylmethyl cellulose; (c) 2 to 6 percent polyvinylpyrrolidone; (d) 1 to 3 percent magnesium stearate; and (e) 14 to 38 percent lactose.
Claim 4
Dependent Claim
45 words
The long acting diltiazem tablet defined in claim 2 consisting essentially of (a) 14 to 38 percent diltiazem hydrochloride; (b) 35 to 45 percent hydroxypropylmethyl cellulose; (c) about 4 percent polyvinylpyrrolidone, (d) 1 to 2 percent magnesium stearate; and (e) 14 to 38 percent lactose.
Claim 5
Dependent Claim
94 words
A long acting diltiazem coated tablet wherein the tablet core consists essentially of: diltiazem or a pharmaceutically acceptable salt thereof in an amount of from 3 to 80 percent by weight; a swellable hydrophilic polymer in an amount of at least 35 percent by weight; a binder in an amount of 2 to 6 percent by weight; a lubricant in an amount of 0.5 to 3 percent by weight; and a diluent in an amount of 10 to 50 percent by weight; and wherein the coating comprises film forming agents in combination with plasticizers.
Claim 6
Dependent Claim
94 words
A long acting diltiazem coated tablet wherein the tablet core consists essentially of: diltiazem or a pharmaceutically acceptable salt thereof in an amount of from 3 to 80 percent by weight; a swellable hydrophilic polymer in an amount of at least 35 percent by weight; a binder in an amount of 2 to 6 percent by weight; a lubricant in an amount of 0.5 to 3 percent by weight; and a diluent in an amount of 10 to 50 percent by weight; and wherein the coating comprises film forming agents in combination with plasticizers.
References Cited (Backward Citations)
US4411933A
Cited
US4443497A
Cited
US4462982A
Cited
US4389393B1
Cited
US4389393A
Cited
JPS5910512A
Cited
US4542042A
Cited
JPS5959632A
Cited
JPS5965009A
Cited
BE898819A
Cited
BE900817R
Cited
BE900824A
Cited
BE901359A
Cited
US4721619A
Cited
BE903540A
Cited
JPS61212517A
Cited
JPS625915A
Cited
US4784858A
Cited
EP0315197A1
Cited
US4804540A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1994-03-18 | 1994-09-17 | 1995-03-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1998-03-18 | 1998-09-17 | 1999-03-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2002-03-18 | 2002-09-17 | 2003-03-19 | $7700.00 | Window Closed / Lapsed |