Microcapsules and method of preparing same

Claim 2

In ethylcellulose microcapsules comprising (i) particles of a core material and (ii) ethylcellulose coating walls deposited on and around said particles of the core material, the improvement wherein a polymer material which shows at least 1.2 times increase in weight by immersing it in water at 37° C. is incorporated into the ethylcellulose coating walls and/or the core material of the microcapsules, said polymer material being taken from the class consisting of agar, hydroxypropyl-cellulose having a hydroxypropoxy content of 2-7 w/w %, free carboxymethylcellulose or its alkaline earth metal salt, starch.acrylic acid graft copolymer or its alkali metal salt, starch.acrylonitrile graft copolymer, cellulose.acrylic acid graft copolymer or its alkali metal salt, cellulose.acrylonitrile graft copolymer, polyvinylalcohol.acrylic acid graft copolymer or its alkali metal salt, epichlorohydrin cross-linked dextrin, epichlorohydrin cross-linked gum arabic, epichlorohydrin cross-linked dextran, epichlorohydrin cross-linked polyvinylalcohol, formaldehyde cross-linked gelatin, acrylic acid cross-linked polyacrylic acid, divinylbenzene acrylic acid copolymer or its alkali metal salt, divinylbenzene methacrylic acid copolymer or its alkali metal salt and divinylbenzene styrenesulfonic acid copolymer or its alkali metal salt.

Claim 3

The microcapsules of claim 1 wherein said ethylcellulose has an ethoxy content of 46.5 to 55.0 w/w% and is present in an amount of 0.01 to 10.0 grams per gram of core material, there being at least 0.01 grams of said polymer material per gram of said ethylcellulose.

Claim 4

The microcapsules of claim 1 wherein there is 0.01 to 20 grams of said polymer material per gram of said ethylcellulose.

Claim 5

The microcapsules of claim 1 wherein the core material comprises a pharmaceutically active compound having a particle size of 30-1000μ, ethylcellulose having an ethoxy content of 46.5 to 55 w/w % and a viscosity (measured at 25° C. with respect to a 5 w/w % solution of it in tolueneethanol (4:1)) of 3 to 500 cP is used in an amount of 0.01 to 10 grams per gram of the core material, and the polymer material having a particle size of 0.1 to 300μ is used in an amount of 0.01 to 20 grams per gram of ethylcellulose.

Claim 6

The microcapsules of any one of claims 1 to 4 wherein at least one member selected from the group consisting of a phase-separation-inducing agent, an organosilicon polymer and a surfactant is further added to the solution of ethylcellulose.

Claim 7

A process for preparing ethylcellulose microcapsules, which comprises the steps of: (i) dissolving ethylcellulose in cyclohexane to form a solution, (ii) dispersing particles of a core material in said solution, (iii) cooling the dispersion in the presence of a polymer material until ethylcellulose separates out from the dispersion to form coating walls on and around the particles of the core material, said polymer material showing at least 1.2 times increase in weight when immersed in water at 37° C. and being selected from the class consisting of agar, hydroxypropyl-cellulose having a hydroxypropoxy content of 2-7 w/w %, free carboxymethylcellulose or its alkaline earth metal salt, starch.acrylic acid graft copolymer or its alkali metal salt, starch.acrylonitrile graft copolymer, cellulose.acrylic acid graft copolymer or its alkali metal salt, cellulose.acrylonitrile graft copolymer, polyvinylalcohol.acrylic acid graft copolymer or its alkali metal salt, epichlorohydrin cross-linked dextrin, epichlorohydrin cross-linked gum arabic, epichlorohydrin cross-linked dextran, epichlorohydrin cross-linked polyvinylalcohol, formaldehyde cross-linked gelatin, acrylic acid-cross-linked polyacrylic acid, divinylbenzene.acrylic acid copolymer or its alkali metal salt, divinylbenzene methacrylic acid copolymer or its alkali metal salt, and divinylbenzene.styrenesulfonic acid copolymer or its alkali metal salt, and (iv) recovering the resultant microcapsules therefrom.

Claim 8

A process for preparing ethylcellulose microcapsules, which comprises the steps of: (i) dissolving ethylcellulose in cyclohexane to form a solution, (ii) dispersing particles of a core material in said solution, (iii) cooling the dispersion in the presence of a polymer material until ethylcellulose separates out from the dispersion to form coating walls on and around the particles of the core material, said polymer material showing at least 1.2 times increase in weight when immersed in water at 37° C. and being selected from the class consisting of agar, hydroxypropyl-cellulose having a hydroxypropoxy content of 2-7 w/w %, free carboxymethylcellulose or its alkaline earth metal salt, starch.acrylic acid graft copolymer or its alkali metal salt, starch.acrylonitrile graft copolymer, cellulose.acrylic acid graft copolymer or its alkali metal salt, cellulose.acrylonitrile graft copolymer, polyvinylalcohol.acrylic acid graft copolymer or its alkali metal salt, epichlorohydrin cross-linked dextrin, epichlorohydrin cross-linked gum arabic, epichlorohydrin cross-linked dextran, epichlorohydrin cross-linked polyvinylalcohol, formaldehyde cross-linked gelatin, acrylic acid-cross-linked polyacrylic acid, divinylbenzene.acrylic acid copolymer or its alkali metal salt, divinylbenzene methacrylic acid copolymer or its alkali metal salt, and divinylbenzene.styrenesulfonic acid copolymer or its alkali metal salt, and (iv) recovering the resultant microcapsules therefrom.

Claim 9

The process according to claim 6, wherein ethylcellulose having an ethoxy content of 46.5 to 55 w/w % is used in an amount of 0.01 to 10 grams per gram of the core material, and the polymer material is used in an amount of not less than 0.1 gram per gram of ethylcellulose.

Claim 10

The process according to claim 6, wherein the polymer material is used in an amount of 0.01 to 20 grams per gram of ethylcellulose.

Claim 11

The process according to claim 6, wherein the core material comprises a pharmaceutically active compound having a particle size of 30-1000μ, ethylcellulose having an ethoxy content of 46.5 to 55 w/w % and a viscosity (measured at 25° C. with respect to a 5 w/w % solution of it in toluene-ethanol (4:1)) of 3 to 500 cP is used in an amount of 0.01 to 10 grams per gram of the core material, and the polymer material having a particle size of 0.1 to 300μ is used in an amount of 0.001 to 20 grams per gram of ethylcellulose.

Claim 12

The process according to any one of claims 6-9, wherein at least one member selected from the group consisting of a phase-separating-inducing agent, an organosilicon polymer and a surfactant is further added to the solution of ethylcellulose.

Claim 13

A process for preparing ethylcellulose microcapsules, which comprises the steps of: (i) dissolving ethylcellulose in cyclohexane to form a solution, (ii) dispersing particles of a polymer material-containing core material in said solution, said polymer material showing at least 1.2 times increase in weight when immersed in water at 37° C. and being selected from the class consisting of agar, hydroxypropylcellulose having a hydroxypropoxy content of 2-7 w/w %, free carboxymethylcellulose or its alkaline earth metal salt, starch.acrylic acid graft copolymer or its alkali metal salt, starch-acrylonitrile graft copolymer, cellulose.acrylic acid graft copolymer or its alkali metal salt, cellulose.acrylonitrile graft copolymer, polyvinylalcohol.acrylic acid graft copolymer or its alkali metal salt, epichlorohydrin cross-linked dextrin, epichlorohydrin cross-linked gum arabic, epichlorohydrin cross-linked dextran, epichlorohydrin cross-linked polyvinylalcohol, formaldehyde cross-linked gelatin, acrylic acid.cross-linked polyacrylic acid, divinylbenzene.acrylic acid copolymer or its alkali metal salt, divinylbenzene.methacrylic acid copolymer or its alkali metal salt, and divinylbenzene.styrenesulfonic acid copolymer or its alkali metal salt, (iii) cooling the dispersion until ethylcellulose separates out from the dispersion to form coating walls on and around the core material, and (iv) recovering the resultant microcapsules therefrom.

Claim 14

A process for preparing ethylcellulose microcapsules, which comprises the steps of: (i) dissolving ethylcellulose in cyclohexane to form a solution, (ii) dispersing particles of a polymer material-containing core material in said solution, said polymer material showing at least 1.2 times increase in weight when immersed in water at 37° C. and being selected from the class consisting of agar, hydroxypropylcellulose having a hydroxypropoxy content of 2-7 w/w %, free carboxymethylcellulose or its alkaline earth metal salt, starch.acrylic acid graft copolymer or its alkali metal salt, starch-acrylonitrile graft copolymer, cellulose.acrylic acid graft copolymer or its alkali metal salt, cellulose.acrylonitrile graft copolymer, polyvinylalcohol.acrylic acid graft copolymer or its alkali metal salt, epichlorohydrin cross-linked dextrin, epichlorohydrin cross-linked gum arabic, epichlorohydrin cross-linked dextran, epichlorohydrin cross-linked polyvinylalcohol, formaldehyde cross-linked gelatin, acrylic acid.cross-linked polyacrylic acid, divinylbenzene.acrylic acid copolymer or its alkali metal salt, divinylbenzene.methacrylic acid copolymer or its alkali metal salt, and divinylbenzene.styrenesulfonic acid copolymer or its alkali metal salt, (iii) cooling the dispersion until ethylcellulose separates out from the dispersion to form coating walls on and around the core material, and (iv) recovering the resultant microcapsules therefrom.

Claim 15

The process according to claim 11, wherein the dispersion is cooled in the presence of a polymer material which shows at least 1.2 times increase in weight when immersed in water at 37° C. and which is selected from the class consisting of agar, hydroxypropylcellulose having a hydroxypropoxy content of 2-7 w/w %, free carboxymethylcellulose or its alkaline earth metal salt, starch.acrylic acid graft copolymer or its alkali metal salt, starch.acrylonitrile graft copolymer, cellulose.acrylic acid graft copolymer or its alkali metal salt, cellulose.acrylonitrile graft copolymer, epichlorohydrin cross-linked dextrin, epichlorohydrin cross-linked gum arabic, epichlorohydrin cross-linked dextran, epichlorohydrin cross-linked polyvinylalcohol, formaldehyde cross-linked gelatin, acrylic acid.cross-linked polyacrylic acid, divinylbenzene acrylic.acid copolymer or its alkali metal salt, divinylbenene.methacrylic acid copolymer or its alkali metal salt and divinylbenzene.styrenesulfonic acid copolymer or its alkali metal salt.

Claim 16

The process according to claim 11 or 12, wherein ethylcellulose having an ethoxy content of 46.5 to 55 w/w % is used in an amount of 0.01 to 10 grams per gram of the core material, and the amount of the polymer material incorporated into the core material is 3 to 99 w/w %.

Claim 17

The process according to claim 11 or 12, wherein the dispersion is cooled in the presence of not less than 0.01 gram of the polymer material per gram of said ethylcellulose.

Claim 18

The process according to claim 11 or 12, wherein the dispersion is cooled in the presence of 0.01 to 20 grams of the polymer material per gram of ethylcellulose.

Claim 19

The process according to claim 11 or 12, wherein the core material is a pharmaceutically active compound having a particle size of 30-100μ, ethylcellulose having an ethoxy content of 46.5 to 55 w/w % and a viscosity, measured at 25° C. with respect to a 5 w/w % solution in toluene-ethanol (4:1), of 3 to 500 cP is used in an amount of 0.01 to 10 grams per gram of the core material.

Claim 20

The process according to claim 11 or 12 wherein at least one member selected from the group consisting of a phase-separation-inducing agent, an orgnosilicon polymer, and a surfactant is added to the solution of ethylcelullose.