US3909444A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Microcapsule
Assignee: NCR Voyix Corp
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Filing: 1971-08-05
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Granted: 1975-09-30
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Expires: 1991-08-05
Abstract
Abstract An enterically active, controlled release microcapsule is disclosed which includes: (a) an internal phase or capsule core of a continuous matrix of water-soluble polymeric material having finely-divided particles of an active contained material and finely-divided particles of an enteric contained material mixed throughout; and (b) a seamless external coating of capsule wall of a water-insoluble polymeric material which prevents disintegration of the internal phase in aqueous liquids but which is permeable to aqueous solutions.
Inventors
- 👤 Jerrold L Anderson
- 👤 Thomas C Powell
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:51
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5042; A61K9/5047; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; B; B01; B01J; B01J13/00; B01J13/02; Y; Y10; Y10S; Y10S436/00; Y10S436/829; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2989; Y10T428/2991; Y10T428/2998
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
75 words
A MICROCAPSULE CONSISTING OF AN INTERNAL PHASE AND A WATER SOLUBLE CAPSULE WALL PERMEABLE TO AQUEOUS SOLUTION WHEREIN THE INTERNAL PHASE COMPRISES AN INDIVIDUAL PARTICLE OF A CONTINUOUS MATRIX OF WATER-SOLUBLE MATERIAL AND, DISTRIBUTED SUBSTANTIALLY EVENLY THROUGHOUT THE CONTINUOUS MATRIX, A PLURALITY OF FINELY-DIVIDED PARTICLES OF AN ACTIVE MATERIAL AND A PLURALITY OF FINELY-DIVIDED PARTICLES OF ENTERIC MATERIAL AND WHEREIN THE WATER INSOLUBLE CAPSULE WALL PERMEABLE TO AQUEOUS SOLUTIONS COMPRISES A THIN COATING OF WATER-INSOLUBLE
Claim 2
Dependent Claim
75 words
A MICROCAPSULE CONSISTING OF AN INTERNAL PHASE AND A WATER SOLUBLE CAPSULE WALL PERMEABLE TO AQUEOUS SOLUTION WHEREIN THE INTERNAL PHASE COMPRISES AN INDIVIDUAL PARTICLE OF A CONTINUOUS MATRIX OF WATER-SOLUBLE MATERIAL AND, DISTRIBUTED SUBSTANTIALLY EVENLY THROUGHOUT THE CONTINUOUS MATRIX, A PLURALITY OF FINELY-DIVIDED PARTICLES OF AN ACTIVE MATERIAL AND A PLURALITY OF FINELY-DIVIDED PARTICLES OF ENTERIC MATERIAL AND WHEREIN THE WATER INSOLUBLE CAPSULE WALL PERMEABLE TO AQUEOUS SOLUTIONS COMPRISES A THIN COATING OF WATER-INSOLUBLE
Claim 3
Dependent Claim
80 words
A minute, enterically active, microcapsule having a capsule wall permeable to aqueous solutions and consisting essentially of hydrophobic polymeric film-forming material insoluble in aqueous systems and a solid core of finely-divided water-soluble active material and finely-divided enteric material intimately combined with a matrix of water-soluble binder material wherein the enteric material is relatively insoluble in acidic aqueous systems and is relatively more soluble in aqueous systems of decreased acidity and wherein the capsule wall prevents disintegration of the solid core.
Claim 4
Dependent Claim
80 words
A minute, enterically active, microcapsule having a capsule wall permeable to aqueous solutions and consisting essentially of hydrophobic polymeric film-forming material insoluble in aqueous systems and a solid core of finely-divided water-soluble active material and finely-divided enteric material intimately combined with a matrix of water-soluble binder material wherein the enteric material is relatively insoluble in acidic aqueous systems and is relatively more soluble in aqueous systems of decreased acidity and wherein the capsule wall prevents disintegration of the solid core.
Claim 5
Dependent Claim
16 words
The capsule of claim 2 wherein the hydrophobic polymeric film-forming capsule wall material is ethyl cellulose.
Claim 6
Dependent Claim
14 words
The capsule of claim 3 wherein the enteric material is cellulose acetate hydrogen phthalate.
Claim 7
Dependent Claim
74 words
A capsule consisting of: a. a substantially water insoluble capsule wall permeable to aqueous solutions and b. an internal phase comprising i. a water-soluble, continuous, matrix binding ii. a multitude of particles of finely-divided active material and iii. a multitude of particles of finely-divided enteric material wherein the enteric material and the active material are substantially homogeneously dispersed in and bound by the matrix and the capsule wall prevents disintegration of the internal phase.
Claim 8
Dependent Claim
74 words
A capsule consisting of: a. a substantially water insoluble capsule wall permeable to aqueous solutions and b. an internal phase comprising i. a water-soluble, continuous, matrix binding ii. a multitude of particles of finely-divided active material and iii. a multitude of particles of finely-divided enteric material wherein the enteric material and the active material are substantially homogeneously dispersed in and bound by the matrix and the capsule wall prevents disintegration of the internal phase.
Claim 9
Dependent Claim
43 words
The capsule of claim 5 wherein the capsule wall consists essentially of a film of water insoluble, hydrophobic, polymeric material permeable to aqueous solutions and encasing the internal phase in conformance with the internal phase shape and preventing disintegration of the internal phase.
Claim 10
Dependent Claim
27 words
The capsule of claim 6 wherein the particle of active material are water soluble and of a size substantially the same as the particles of enteric material.
Claim 11
Dependent Claim
27 words
The capsule of claim 6 wherein the internal phase is substantially spherical and of a size more than about 100 microns and less than about 1000 microns.
Claim 12
Dependent Claim
24 words
The capsule of claim 8 wherein the internal phase constitutes 85 to 98 percent, by weight, of the capsule;-the remainder being capsule wall material.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-29 | 1979-03-31 | 1979-09-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-29 | 1983-03-31 | 1983-09-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-29 | 1987-03-31 | 1987-09-30 | $7700.00 | Window Closed / Lapsed |