US4968400A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enzyme sensor
Assignee: Terumo Corp
•
Filing: 1989-07-19
•
Granted: 1990-11-06
•
Expires: 2009-07-19
Abstract
Abstract PCT Filed Nov. 19, 1987 PCT Pub. No. WO88/04050 PCT Pub. Date Jun. 2, 1988. An insulative substrate (1) is coated with an electrically conductive layer (2) and a redox layer (3) which comprises an electrolytic polymerization film of 2,6-dimethylphenol, and the surface of the redox layer is provided with an enzyme-fixed (7). The enzyme electrode thus obtained exhibits a potentiometric response, and the enzyme-fixed layer has a strong adhesion. As a result, sensitivity is high, there is little drift and service life is prolonged. An ion-selective field-effect transistor can be used instead of the insulative substrate (1).
Inventors
- 👤 Takeshi Shimomura
- 👤 Shuichiro Yamaguchi
- 👤 Naoto Uchida
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 20:54
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; G01N27/28; G01N27/30; C; C12; C12Q; C12Q1/00; C12Q1/001; C12Q1/004; G01N27/403; G01N27/414; G01N27/4145; Y; Y10; Y10S; Y10S435/00; Y10S435/817
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
56 words
An enzyme sensor characterized by comprising: an insulating substrate; an electrically conductive layer coating said insulating substrate; a redox layer having an oxidation-reduction function formed on a surface of said electrically conductive layer by an electrolytic oxidative polymerization process; and an enzyme-fixed layer coating a surface of said redox layer and having an enzyme fixed thereto.
Claim 2
Dependent Claim
56 words
An enzyme sensor characterized by comprising: an insulating substrate; an electrically conductive layer coating said insulating substrate; a redox layer having an oxidation-reduction function formed on a surface of said electrically conductive layer by an electrolytic oxidative polymerization process; and an enzyme-fixed layer coating a surface of said redox layer and having an enzyme fixed thereto.
Claim 3
Dependent Claim
22 words
The enzyme sensor according to claim 1, characterized in that said insulating substrate is selected from among substances exhibiting an insulating property.
Claim 4
Dependent Claim
23 words
The enzyme sensor according to claim 1, characterized in that said electrically conductive layer is selected from among substances manifesting an oxidation-reduction reaction.
Claim 5
Dependent Claim
21 words
The enzyme sensor according to claim 1, characterized in that said redox layer is a layer sensitive to hydrogen ion concentration.
Claim 6
Dependent Claim
21 words
The enzyme sensor according to claim 1, characterized in that said enzyme layer is formed by an electrolytic (oxidative) polymerization process.
Claim 7
Dependent Claim
24 words
The enzyme sensor according to claim 1, characterized in that said enzyme-fixed layer is formed by a crosslinking process or by an incorporating process.
Claim 8
Dependent Claim
59 words
An enzyme sensor characterized by comprising: a MOSFET: an electrically conductive layer coating a gate insulating film of said MOSFET; a redox layer having an oxidation-reduction function formed on a surface of said electrically conductive layer by an electrolytic oxidative polymerization process; and an enzyme-fixed layer coating a surface of said redox layer and having an enzyme fixed thereto.
Claim 9
Dependent Claim
59 words
An enzyme sensor characterized by comprising: a MOSFET: an electrically conductive layer coating a gate insulating film of said MOSFET; a redox layer having an oxidation-reduction function formed on a surface of said electrically conductive layer by an electrolytic oxidative polymerization process; and an enzyme-fixed layer coating a surface of said redox layer and having an enzyme fixed thereto.
Claim 10
Dependent Claim
23 words
The enzyme sensor according to claim 7, characterized in that said electrically conductive layer is selected from among substances manifesting an oxidation-reduction reaction.
Claim 11
Dependent Claim
27 words
The enzyme sensor according to claim 7, characterized in that said electrically conductive layer is an isolated gate formed at a small distance from a FET portion.
Claim 12
Dependent Claim
21 words
The enzyme sensor according to claim 7, characterized in that said redox layer is a layer sensitive to hydrogen ion concentration.
Claim 13
Dependent Claim
21 words
The enzyme sensor according to claim 7, characterized in that said enzyme-fixed layer is formed by an electrolytic (oxidative) polymerization process.
Claim 14
Dependent Claim
24 words
The enzyme sensor according to claim 7, characterized in that said enzyme-fixed layer is formed by a crosslinking process or by an incorporating process.
References Cited (Backward Citations)
US3598713A
Cited
US3926764A
Cited
US3932233A
Cited
US3957612A
Cited
US4115209A
Cited
US3957613A
Cited
JPS5167951A
Cited
US4052285A
Cited
JPS5230490A
Cited
US4280889A
Cited
JPS5451595A
Cited
US4214968A
Cited
JPS54140594A
Cited
US4198851A
Cited
SU898314A1
Cited
US4305802A
Cited
US4282079A
Cited
JPS5763444A
Cited
JPS57118153A
Cited
DE3134760A1
Cited
US4563263A
Cited
US4632732A
Cited
US4512870A
Cited
US4454007A
Cited
JPS59164952A
Cited
JPS59166852A
Cited
EP0136362A1
Cited
JPS59176662A
Cited
US4561962A
Cited
US4711245A
Cited
JPS59210356A
Cited
JPS6052759A
Cited
JPS6073351A
Cited
US4549951A
Cited
US4615954A
Cited
EP0186210A2
Cited
US4816118A
Cited
US4704193A
Cited
US4797181A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-11-05 | 1994-05-07 | 1994-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-11-05 | 1998-05-07 | 1998-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-11-05 | 2002-05-07 | 2002-11-06 | $7700.00 | Window Closed / Lapsed |