Patent FR718235A successfully refreshed from Google Patents.
Patent US4908404A successfully refreshed from Google Patents.
US4908404A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Synthetic amino acid-and/or peptide-containing graft copolymers
Assignee: AL MARZOOK UNITED COMMERCIAL Co A CORP OF KUWAIT
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Filing: 1988-08-22
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Granted: 1990-03-13
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Expires: 2008-08-22
Abstract
Abstract A water soluble cationic peptide-containing graft copolymer exhibiting a number average molecular weight of from about 30,000 to about 500,000 are provided comprising: (a) a polymeric backbone containing or capable of modification to include free primary or secondary amine functional groups for reaction with an amino acid or peptide graft and exhibiting a number average molecular weight from about 10,000 to about 250,000; and (b) an amino acid or peptide graft reacted with from at least about 5% to about 100% of the primary or secondary amine functional groups of the polymeric backbone, wherein said amino acid or peptide graft comprises at least one 3,4-dihydroxyphenylalaine (Dopa) amino acid or a precursor thereof capable of hydroxylation to the Dopa form. The peptide-containing graft copolymers of the present invention can vary in (a) molecular weight, cationicity, percent substitution of the amino acid or peptide unit grafted to the polymer backbone and (b) the chemical and physical structure of the peptide-containing graft copolymer itself, thereby enabling specific tailoring of the polymers of the present invention for particular end-use applications.
Inventors
- 👤 Christine V. Benedict
- 👤 Nishith Chaturvedi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 00:56
CPC Classifications
C; C08; C08F; C08F8/00; C08F8/30
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
118 words
A water-soluble cationic peptide-containing graft copolymer exhibiting a number average molecular weight of from about 30,000 to about 500,000 comprising: (a) a polymeric backbone containing or capable of modification to include free primary or secondary amine functional groups for reaction with an amino acid or peptide graft, said polymeric backbone exhibiting a number average molecular weight of from about 10,000 to about 250,000; and (b) an amino acid or peptide graft reacted with from at least 5% to about 100% of said primary or secondary amine functional groups of said polymeric backbone, wherein said amino acid or peptide graft comprises at least one 3,4-dihydroxyphenylalanine (Dopa) amino acid or a precursor thereof capable of hydroxylation to the Dopa form.
Claim 2
Dependent Claim
118 words
A water-soluble cationic peptide-containing graft copolymer exhibiting a number average molecular weight of from about 30,000 to about 500,000 comprising: (a) a polymeric backbone containing or capable of modification to include free primary or secondary amine functional groups for reaction with an amino acid or peptide graft, said polymeric backbone exhibiting a number average molecular weight of from about 10,000 to about 250,000; and (b) an amino acid or peptide graft reacted with from at least 5% to about 100% of said primary or secondary amine functional groups of said polymeric backbone, wherein said amino acid or peptide graft comprises at least one 3,4-dihydroxyphenylalanine (Dopa) amino acid or a precursor thereof capable of hydroxylation to the Dopa form.
Claim 3
Dependent Claim
24 words
A peptide-containing graft copolymer according to claim 1 wherein the number average molecular weight of said copolymer ranges from about 50,000 to about 350,000.
Claim 4
Dependent Claim
24 words
A peptide-containing graft copolymer according to claim 1 wherein the number average molecular weight of said copolymer ranges from about 70,000 to about 350,000.
Claim 5
Dependent Claim
20 words
A peptide-containing graft copolymer according to claim 1 wherein the number average molecular weight of said copolymer is about 100,000.
Claim 6
Dependent Claim
28 words
A peptide-containing graft copolymer according to claim 1 wherein said polymeric backbone containing free primary or secondary amine functional units exhibits a pK of at least about 8.
Claim 7
Dependent Claim
30 words
A peptide-containing graft copolymer according to claim 1 wherein the polymeric backbone containing free primary or secondary amine functional units exhibits a pK of from about 8.5 to about 10.
Claim 8
Dependent Claim
53 words
A peptide-containing graft copolymer according to claim 1 wherein said backbone comprises monomer units containing free primary or secondary amine functional groups, which amine groups are present in an amount of at least about 1-25 millimoles free amine group/gram polymer containing said amine groups for reaction with said amino acid or peptide graft.
Claim 9
Dependent Claim
24 words
A peptide-containing graft copolymer according to claim 1 wherein said backbone exhibits a number average molecular weight of from about 10,000 to about 250,000.
Claim 10
Dependent Claim
40 words
A peptide-containing graft copolymer according to claim 1 wherein said polymeric backbone is selected from the group consisting of polylysine, polyallylamine, polyethylenimine, chitosan, polyvinylamine, chrondroitin sulfate, polydextran, hyaluronic acid, polyacrylic acid, and copolymers of any of the copolymerizable monomers thereof.
Claim 11
Dependent Claim
14 words
A peptide-containing graft copolymer according to claim 1 wherein said polymeric backbone is polylysine.
Claim 12
Dependent Claim
14 words
A peptide-containing graft copolymer according to claim 1 wherein said polymeric backbone is polyallylamine.
Claim 13
Dependent Claim
35 words
A peptide-containing graft copolymer according to claim 10 wherein from at least about 5% to about 30% of said free primary or secondary free amine groups are reacted with said amino acid or peptide graft.
Claim 14
Dependent Claim
32 words
A peptide-containing graft copolymer according to claim 10 wherein from about 10% to about 20% of said free primary or secondary amine groups are reacted with said amino acid or peptide graft.
Claim 15
Dependent Claim
35 words
A peptide-containing graft copolymer according to claim 11 wherein from at least about 5% to about 30% of said free primary or secondary free amine groups are reacted with said amino acid or peptide graft.
Claim 16
Dependent Claim
32 words
A peptide-containing graft copolymer according to claim 11 wherein from about 10% to about 20% of said free primary or secondary amine groups are reacted with said amino acid or peptide graft.
Claim 17
Dependent Claim
20 words
A peptide-containing graft copolymer according to claim 1 wherein said amino acid or peptide graft comprises 3,4-dihydroxyphenylalanine (Dopa) amino acid.
Claim 18
Dependent Claim
27 words
A peptide-containing graft copolymer according to claim 1 wherein said amino acid or peptide graft comprises a precursor of 3,4-dihydroxyphenylalanine capable of hydroxylation to the Dopa form.
Claim 19
Dependent Claim
22 words
A peptide containing graft copolymer according to claim 17, wherein said precursor is selected from the group consisting of tyrosine and phenylalanine.
Claim 20
Dependent Claim
46 words
A peptide-containing graft copolymer according to claim 1 wherein said amino acid or peptide graft is selected from the group consisting of Dopa, Dopa-Lys-Ala-Lys, Hyp-Hyp-Thr-Dopa-Lys, Ala-Lys-Pro-Ser-Dopa, Dopa-Hyp-Hyp-Thr, Hyp-Thr-Dopa-Lys, Dopa-Hyp-Lys-Ser, Dopa-Lys-Ala-Lys-Hyp-Ser-Tyr, Dopa-Lys-Ala-Lys-Hyp-Ser-Tyr-Hyp-Hyp-Thr, Lys-Hyp-Ser-Dopa-Hyp-Hyp-Thr-Dopa-Lys, Dopa-Lys-Glu-Ser-Hyp, Dopa-Lys-Cys(SO 3 H)-Lys, Cys(SO 3 )-Lys-Pro-Ser-Tyr-Hyp-Hyp-Thr-Dopa-Lys, and Lys-Dopa-Thr-Hyp-Hyp-Tyr-Ser-Pro-Lys-Ala, Hyp-Hyp-Thr-Tyr-Lys, Ala-Lys-Pro-Ser-Typ, Phe-Tyr-Lys-Ser, and Hyp-Hyp-Thr-Phe-Lys.
Claim 21
Dependent Claim
36 words
A peptide-containing graft copolymer according to claim 1 wherein said polymeric backbone is polylysine and said amino acid or peptide graft is selected from the group consisting of Lys-Dopa-Thr-Hyp-Hyp-Tyr-Ser-Pro-Lys-Ala, Lys-Pro-Ser-Tyr-Hyp-Hyp-Thr-Dopa-Lys, Lys-Hyp-Ser-Dopa-Hyp-Hyp-Thr-Dopa-Lys, Ala-Lys-Pro-Ser-Tyr-Hyp-Thr-Dopa-Lys, Dopa-Lys-Ala-Lys-Pro-Ser-Tyr, Dopa-Lys-Ala-Lys-Ala-Lys-Hyp-Ser-Dopa-Hyp-Hyp-Thr and Dopa.
Claim 22
Dependent Claim
35 words
A peptide-containing graft copolymer according to claim 1 wherein said polymeric backbone is polyallylamine and said amino acid or peptide graft is selected from the group consisting of Dopa, Lys-Pro-Ser-Tyr-Hyp-Hyp-Thr-Dopa-Lys, Cys-Pro-Ser-Thr-Pro-Pro-Thr-Thr-Lys, Hyp-Thr-Dopa-Lys, Dopa-Lys-Ala-Lys-Pro-Ser-Tyr, and Dopa-Lys-Ala-Lys-Hyp-Ser-Dopa-Hyp-Hyp-Thr.
Claim 23
Dependent Claim
23 words
A peptide-containing graft copolymer according to claim 1 wherein said polymeric backbone is polyallylamine and said amino acid or peptide graft is Dopa.
Claim 24
Dependent Claim
23 words
A peptide-containing graft copolymer according to claim 1 wherein said polymeric backbone is polyallylamine and said amino acid or peptide graft is SA-Lys-Pro-Tyr-Hyp-Hyp-Thr-Dopa-Lys-OH.
Claim 25
Dependent Claim
121 words
A water-soluble cationic peptide-containing graft copolymer exhibiting a molecular weight of from about 30,000 to about 500,000 comprising: (a) a polymeric backbone comprising monomer repeat units, each of said monomer repeat units including or capable of modification to include free primary or secondary amine functional units for reaction with an amino acid or peptide graft, said polymeric backbone exhibiting a number average molecular weight of from about 10,000 to about 250,000; and (b) an amino acid or peptide graft reacted with at least 5% of said primary or secondary amine functional units of said polymeric backbone, wherein said amino acid or peptide graft comprises at least one 3,4-dihydroxyphenyalanine (Dopa) amino acid or precursor thereof capable of hydroxylation to the Dopa form.
Claim 26
Dependent Claim
121 words
A water-soluble cationic peptide-containing graft copolymer exhibiting a molecular weight of from about 30,000 to about 500,000 comprising: (a) a polymeric backbone comprising monomer repeat units, each of said monomer repeat units including or capable of modification to include free primary or secondary amine functional units for reaction with an amino acid or peptide graft, said polymeric backbone exhibiting a number average molecular weight of from about 10,000 to about 250,000; and (b) an amino acid or peptide graft reacted with at least 5% of said primary or secondary amine functional units of said polymeric backbone, wherein said amino acid or peptide graft comprises at least one 3,4-dihydroxyphenyalanine (Dopa) amino acid or precursor thereof capable of hydroxylation to the Dopa form.
Claim 27
Dependent Claim
26 words
A water soluble cationic peptide-containing graft copolymer according to claim 24 wherein said monomer repeat units are selected from the group consisting of lysine and allylamine.
Claim 28
Dependent Claim
43 words
A water soluble cationic peptide-containing graft copolymer according to claim 24 wherein the free primary or secondary amine functional units are present in an amount of at least about 1-25 millimoles amine/gram of polymer for reaction with said amino acid or peptide graft.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1993-03-12 | 1993-09-11 | 1994-03-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1997-03-12 | 1997-09-11 | 1998-03-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2001-03-12 | 2001-09-11 | 2002-03-13 | $7700.00 | Window Closed / Lapsed |