Patent US4871731A successfully refreshed from Google Patents.
US4871731A
Expired / Lapsed
US
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Captopril and diltiazem composition and the like
Assignee: Aventis Pharmaceuticals Inc
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Filing: 1987-10-07
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Granted: 1989-10-03
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Expires: 2007-10-07
Abstract
Abstract A combination of the titled compounds, appropriate salt(s) thereof, and/or the like, is employed for significantly alleviating hypertension and so forth.
Inventors
- 👤 Steven D. Walker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 17:12
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/55
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
46 words
A pharmaceutical composition useful for treating hypertension comprising a mixture of captopril or its pharmaceutically acceptable salt(s) and diltiazem or its pharmaceutically acceptable salt(s) in a ratio of diltiazem or its said salt(s) to captopril or its said salt(s) about from 2:1 to 3:1 by weight.
Claim 2
Dependent Claim
46 words
A pharmaceutical composition useful for treating hypertension comprising a mixture of captopril or its pharmaceutically acceptable salt(s) and diltiazem or its pharmaceutically acceptable salt(s) in a ratio of diltiazem or its said salt(s) to captopril or its said salt(s) about from 2:1 to 3:1 by weight.
Claim 3
Dependent Claim
14 words
The composition of claim 1, which is in a pharmaceutically acceptable intravenous dosage form.
Claim 4
Dependent Claim
14 words
The composition of claim 1, which is in a pharmaceutically acceptable oral dosage form.
Claim 5
Dependent Claim
33 words
The composition of claim 3, wherein the diltiazem or its said salt(s) is sustainably releasable in a substantially linear manner in about from 12 hours to a day in a suitable human patient.
Claim 6
Dependent Claim
10 words
The composition of claim 4, which is in capsule form.
Claim 7
Dependent Claim
10 words
The composition of claim 4, which is in tablet form.
Claim 8
Dependent Claim
17 words
The composition of claim 1, 2, 3, 4, 5 or 6, wherein said ratio is about 2.4:1.
Claim 9
Dependent Claim
30 words
A pharmaceutical composition useful for treating hypertension comprising a mixture of captopril and diltiazem hydrochloride in a ratio of diltiazem hydrochloride to captopril about from 2:1 to 3:1 by weight.
Claim 10
Dependent Claim
30 words
A pharmaceutical composition useful for treating hypertension comprising a mixture of captopril and diltiazem hydrochloride in a ratio of diltiazem hydrochloride to captopril about from 2:1 to 3:1 by weight.
Claim 11
Dependent Claim
14 words
The composition of claim 8, which is in a pharmaceutically acceptable intravenous dosage form.
Claim 12
Dependent Claim
14 words
The composition of claim 8, which is in a pharmaceutically acceptable oral dosage form.
Claim 13
Dependent Claim
30 words
The composition of claim 10, wherein the diltiazem hydrochloride is sustainably releasable in a substantially linear manner in about from 12 hours to a day in a suitable human patient.
Claim 14
Dependent Claim
10 words
The composition of claim 11, which is in capsule form.
Claim 15
Dependent Claim
10 words
The composition of claim 11, which is in tablet form.
Claim 16
Dependent Claim
17 words
The composition of claim 8, 9, 10, 11, 12 or 13, wherein said ratio is about 2.4:1.
Claim 17
Independent Claim
56 words
A method for treating hypertension which comprises concurrently administering to a hypertensive subject an amount effective to treat hypertension of both captopril or its pharmaceutically acceptable salt(s) and diltiazem or its pharmaceutically acceptable salt(s) in a ratio of diltiazem or its said salt(s)) to captopril or its said salt(s) about from 2:1 to 3:1 by weight.
Claim 18
Independent Claim
56 words
A method for treating hypertension which comprises concurrently administering to a hypertensive subject an amount effective to treat hypertension of both captopril or its pharmaceutically acceptable salt(s) and diltiazem or its pharmaceutically acceptable salt(s) in a ratio of diltiazem or its said salt(s)) to captopril or its said salt(s) about from 2:1 to 3:1 by weight.
Claim 19
Dependent Claim
24 words
The method of claim 15, wherein the captopril or its said salt(s) is captopril, and the diltiazem or its said salt(s) is diltiazem hydrochloride.
Claim 20
Dependent Claim
15 words
The method of claim 15 or 16, wherein the hypertensive subject is a human patient.
Claim 21
Dependent Claim
19 words
The method of claim 17, wherein the diltiazem or its said salt(s) is administered in a substantially linear manner.
Claim 22
Dependent Claim
29 words
The method of claim 18, wherein the captopril or its said salt(s) and the diltiazem or its said salt(s) are administered together in a pharmaceutically acceptable oral dosage form.
Claim 23
Dependent Claim
30 words
The method of claim 17, wherein the human patient had failed to appropriately respond either to captopril or its said salt(s), or to diltiazem or its said salt(s), as monotherapy.
Claim 24
Dependent Claim
13 words
The method of claim 15 or 16, wherein said ratio is about 2.4:1.
Claim 25
Dependent Claim
11 words
The method of claim 17, wherein said ratio is about 2.4:1.
Claim 26
Dependent Claim
11 words
The method of claim 18, wherein said ratio is about 2.4:1.
Claim 27
Dependent Claim
11 words
The method of claim 19, wherein said ratio is about 2.4:1.
Claim 28
Dependent Claim
11 words
The method of claim 20, wherein said ratio is about 2.4:1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1992-10-02 | 1993-04-03 | 1993-10-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1996-10-02 | 1997-04-03 | 1997-10-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 2000-10-02 | 2001-04-03 | 2001-10-03 | $7700.00 | Window Closed / Lapsed |