Benzazepine derivatives

Claim 1

A compound having the formula ##STR17## or a pharmaceutically acceptable salt thereof wherein R 1 is hydrogen, alkyl, alkanoyl, alkenyl, arylcarbonyl, heteroarylcarbonyl or ##STR18## R 2 and R 3 are each independently hydrogen, alkyl, cycloalkyl or arylalkyl or R 2 and R 3 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl, or morpholinyl; R 4 and R 5 are each independently hydrogen, halogen, alkyl, alkoxy, aryloxy, arylalkoxy, diarylalkoxy, arylalkyl, cyano, hydroxy, alkanoyloxy, ##STR19## fluoro substituted alkoxy, fluoro substituted alkyl, (cycloalkyl)alkoxy, --NO 2 , --NX 3 X 4 , --S(O) m alkyl, --S(O) m aryl, ##STR20## n is 2 or 3; m is 0, 1 or 2; X 1 and X 2 are each independently hydrogen, alkyl, aryl or heteroaryl, or X 1 and X 2 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl or morpholinyl; X 3 and X 4 are each independently hydrogen, alkyl, alkanoyl, arylcarbonyl, heteroacrylcarbonyl, or ##STR21## X 5 is hydroxy, alkoxy, aryloxy, amino, alkylamino or dialkylamino; and X 6 is alkyl, alkoxy or aryloxy; with the proviso that if R4 is a 7-alkyl group, it must have a tertiary carbon atom bonded to the ring; wherein the term "aryl" refers to phenyl and phenyl substituted with 1, 2 or 3 amino, alkylamino, dialkylamino, nitro, halogen, hydroxyl, trifluoromethyl, alkyl or 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkanoyloxy, carbamoyl, or carboxyl groups; the term "heteroaryl" refers to pyridinyl, pyrrolyl, imidazolyl, furyl, thienyl, or thiazolyl; the terms "alkyl" and "alkoxy" refers to groups having 1 to 10 carbon atoms; the term "alkenyl" refers to groups having 2 to 10 carbon atoms; the term "alkanoyl" refers to groups having 2 to 11 carbon atoms; and the term "cycloalkyl" refers to groups having 3, 4, 5, 6 or 7 carbon atoms.