Benzazepine derivatives

Claim 1

A compound having the formula ##STR20## or a pharmaceutically acceptable salt thereof wherein R and R 1 are each hydrogen or alkyl, R is hydrogen and R 1 is alkenyl, alkynyl, aryl, heteroaryl or cycloalkyl, or R and R 1 together with the carbon atom to which they are attached are cycloalkyl; R 2 and R 3 are each independently hydrogen, alkyl, cycloalkyl, or arylalkyl or R 2 and R 3 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl, or morpholinyl; R 4 and R 5 are each independently hydrogen, halogen, alkyl, alkoxy, aryloxy, arylalkoxy, arylalkyl, hydroxy, alkanoyloxy, ##STR21## difluoromethoxy, trifluoromethyl, --NX 3 X 4 , --SO m alkyl, or --SO m aryl; n is 2 or 3; m is 0, 1 or 2; X 1 and X 2 are each independently hydrogen, alkyl, aryl or heteroaryl, or X 1 and X 2 together with the nitrogen atom to which they are attached are a nitrogen containing heteroaryl; X 3 and X 4 are each independently hydrogen, alkyl, alkanoyl, arylcarbonyl, heteroarylcarbonyl, carbamoyl, alkylsulfonyl, or arylsulfonyl; with the proviso that if R 4 is a 7-alkyl group, it must have a tertiary carbon atom bonded to the ring; wherein the term "aryl" refers to phenyl and phenyl substituted with 1, 2 or 3 amino, alkylamino, dialkylamino, nitro, halogen, hydroxyl, trifluoromethyl, alkyl or 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkanoyloxy carbamoyl, or carboxyl groups; the term "heteroaryl" refers to pyridinyl, pyrrolyl, imidazolyl, furyl, thienyl, or thiazolyl; the term "nitrogen containing heteroaryl" refers to pyridinyl, pyrrolyl, imidazolyl and thiazolyl; the terms "alkyl" and "alkoxy" refer to groups having 1 to 10 carbon atoms; the terms "alkenyl" and "alkynyl" refer to groups having 2 to 10 carbon atoms; the term "alkanoyl" refers to groups having 2 to 11 carbon atoms; and the term "cycloalkyl" refers to groups having 3, 4 5, 6 or 7 carbon atoms.