US4832690A — Needle-pierceable cartridge for drug delivery

Claim 1

Independent Claim 108 words

A needle-pierceable cartridge for drug delivery to a patient which comprises: a housing; a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid outside of the bag, the walls of said bag defining a plurality of macroscopic holes; and needle-pierceable sealing means carried by said housing, so that a needle may penetrate said sealing means to provide liquid to the exterior of said bag in the housing whereby, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes for delivery to a site of use.

Claim 2

Dependent Claim 108 words

A needle-pierceable cartridge for drug delivery to a patient which comprises: a housing; a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid outside of the bag, the walls of said bag defining a plurality of macroscopic holes; and needle-pierceable sealing means carried by said housing, so that a needle may penetrate said sealing means to provide liquid to the exterior of said bag in the housing whereby, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes for delivery to a site of use.

Claim 3

Dependent Claim 38 words

The cartridge of claim 1 in which said needle-pierceable sealing means is of sufficient size to receive two, spaced, hollow needles of differing length, one to provide said water and one to receive said water containing dissolved drug.

Claim 4

Dependent Claim 31 words

The cartridge of claim 1 in which said housing is of a generally disk shape, the needle-pierceable sealing means being positioned at the center of one side of said disk-shaped housing.

Claim 5

Dependent Claim 31 words

The cartridge of claim 3 in which said housing defines a dome for receiving a needle tip, said dome being positioned at the center of the other side of said housing.

Claim 6

Dependent Claim 65 words

The cartridge of claim 1, in combination with a pair of hollow needles of differing lengths penetrating said needle-pierceable sealing means, whereby the needle tips are respectively positioned adjacent opposed walls of said housing exterior to said bag, one needle communicating with a source of said liquid and the other needle communicating with means for receiving said liquid having drug from said bag dissolved therein.

Claim 7

Dependent Claim 23 words

The cartridge of claim 5 in which one needle extends entirely through said bag and the other needle terminates short of said bag.

Claim 8

Dependent Claim 173 words

A needle-pierceable cartridge for drug delivery to a patient, which comprises: a housing; a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid across said walls whereby osmosis can take place between the drug in the bag and liquid outside the bag, the walls of said bag defining a plurality of macroscopic holes; needle-pierceable sealing means carried by said housing, said needle-pierceable sealing means being of sufficient size to receive two, spaced, hollow needles of differing length; said support means including inwardly-projecting spikes which penetrate said bag walls to form said plurality of macroscopic holes, whereby said two, spaced hollow needles may penetrate the sealing means to provide liquid to the exterior of said bag in the housing through one of said needles so that, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes and out of the other of said needles for delivery to a site of use.

Claim 9

Dependent Claim 173 words

A needle-pierceable cartridge for drug delivery to a patient, which comprises: a housing; a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid across said walls whereby osmosis can take place between the drug in the bag and liquid outside the bag, the walls of said bag defining a plurality of macroscopic holes; needle-pierceable sealing means carried by said housing, said needle-pierceable sealing means being of sufficient size to receive two, spaced, hollow needles of differing length; said support means including inwardly-projecting spikes which penetrate said bag walls to form said plurality of macroscopic holes, whereby said two, spaced hollow needles may penetrate the sealing means to provide liquid to the exterior of said bag in the housing through one of said needles so that, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes and out of the other of said needles for delivery to a site of use.

Claim 10

Dependent Claim 30 words

The cartridge of claim 7 in which said housing is of a generally disc-shape, the needle-pierceable sealing means being positioned at the center of one side of said disc-shaped housing.

Claim 11

Dependent Claim 31 words

The cartridge of claim 8 in which said housing defines a dome for receiving the needle tip, said dome being positioned at the center of the other side of said housing.

Claim 12

Dependent Claim 65 words

The cartridge of claim 7, in combination with the pair of hollow needles of differing lengths penetrating said needle-pierceable sealing means, whereby the needle tips are respectively positioned adjacent opposed walls of said housing exterior to said bag, one needle communicating with a source of said liquid, and the other needle communicating with means for receiving said liquid having drug from said bag dissolved therein.

Claim 13

Dependent Claim 23 words

The cartridge of claim 10 in which one needle extends entirely through said bag and the other needle terminates short of said bag.

Claim 14

Dependent Claim 31 words

The cartridge of claim 11 in which said housing is of a generally disc shape, the needle-pierceable sealing means being positioned at the center of one side of said disc-shaped housing.

Claim 15

Dependent Claim 23 words

The cartridge of claim 7, in which said spikes are uniformly distributed over the bag area to form uniform distribution of macroscopic holes.

Claim 16

Dependent Claim 140 words

A needle-pierceable cartridge for drug delivery to a patient which comprises: a housing; a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid across said walls whereby osmosis can take place between the drug in the bag and the liquid outside of the bag, the walls of said bag defining a plurality of macroscopic holes; said support means including inwardly projecting spikes which penetrate said bag to form said holes; and needle-pierceable sealing means carried by said housing, so that a needle may penetrate said sealing means to provide liquid to the exterior of said bag in the housing whereby, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes for delivery to a site of use.

Claim 17

Dependent Claim 140 words

A needle-pierceable cartridge for drug delivery to a patient which comprises: a housing; a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid across said walls whereby osmosis can take place between the drug in the bag and the liquid outside of the bag, the walls of said bag defining a plurality of macroscopic holes; said support means including inwardly projecting spikes which penetrate said bag to form said holes; and needle-pierceable sealing means carried by said housing, so that a needle may penetrate said sealing means to provide liquid to the exterior of said bag in the housing whereby, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes for delivery to a site of use.

Claim 18

Dependent Claim 170 words

A needle-pierceable cartridge for drug delivery to a patient, which comprises: a housing; a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid across said walls whereby osmosis can take place between the drug in the bag and liquid outside of the bag, the walls of said bag defining a plurality of macroscopic holes; and needle-pierceable sealing means carried by said housing, said housing being of a generally disc-shape, the needle-pierceable sealing means being positioned at the center of one side of said disc-shaped housing, said housing defining a dome for receiving a needle tip, said dome being positioned at the center of the other side of said housing; whereby a needle may penetrate said sealing means to provide liquid to the exterior of said bag in the housing whereby, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes for delivery to a site of use.

Claim 19

Dependent Claim 170 words

A needle-pierceable cartridge for drug delivery to a patient, which comprises: a housing; a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid across said walls whereby osmosis can take place between the drug in the bag and liquid outside of the bag, the walls of said bag defining a plurality of macroscopic holes; and needle-pierceable sealing means carried by said housing, said housing being of a generally disc-shape, the needle-pierceable sealing means being positioned at the center of one side of said disc-shaped housing, said housing defining a dome for receiving a needle tip, said dome being positioned at the center of the other side of said housing; whereby a needle may penetrate said sealing means to provide liquid to the exterior of said bag in the housing whereby, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes for delivery to a site of use.

Claim 20

Dependent Claim 25 words

The cartridge of claim 14 in which said inwardly projecting spikes are uniformly distributed over the bag area to form uniform distribution of macroscopic holes.

Claim 21

Dependent Claim 27 words

The cartridge of claim 1 in which said housing is of a generally elongated shape, the needle-pierceable sealing means being positioned on one end of said housing.

Claim 22

Dependent Claim 24 words

The cartridge of claim 1 in which means are provided for pressing said bag into generally flat configuration to minimize open, drug-free volume therein.

Claim 23

Dependent Claim 26 words

The cartridge of claim 7 in which said housing is of generally elongated shape, the needle-pierceable sealing means being positioned on one end of said housing.

Claim 24

Dependent Claim 24 words

The cartridge of claim 12 in which means are provided for pressing said bag into generally flat configuration to minimize open, drug-free volume therein.

Claim 25

Dependent Claim 24 words

The cartridge of claim 7 in which means are provided for pressing said bag into generally flat configuration to minimize open, drug-free volume therein.

Claim 26

Dependent Claim 158 words

A needle-pierceable cartridge for drug delivery to the patient which comprises: a housing, a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid across said walls, whereby osmosis can take place between the drug in the bag and liquid outside of the bag; and needle-pierceable sealing means carried by said housing, said sealing means being of sufficient size to receive two, spaced hollow needles of differing length, the walls of said bag defining a plurality of macroscopic holes so that a needle may penetrate said sealing means to provide liquid to the exterior of said bag in the housing, so that, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes for delivery to a site of use, and means provided for pressing said bag into generally flat configuration to minimize open, drug-free volume therein.

Claim 27

Dependent Claim 158 words

A needle-pierceable cartridge for drug delivery to the patient which comprises: a housing, a drug-containing bag positioned within said housing, means within said housing for supporting said bag, said bag having walls of hydrophilic material capable of diffusing liquid across said walls, whereby osmosis can take place between the drug in the bag and liquid outside of the bag; and needle-pierceable sealing means carried by said housing, said sealing means being of sufficient size to receive two, spaced hollow needles of differing length, the walls of said bag defining a plurality of macroscopic holes so that a needle may penetrate said sealing means to provide liquid to the exterior of said bag in the housing, so that, as osmosis takes place, liquid containing dissolved drug is forced from said bag through said macroscopic holes for delivery to a site of use, and means provided for pressing said bag into generally flat configuration to minimize open, drug-free volume therein.

Claim 28

Dependent Claim 67 words

The cartridge of claim 22, in combination with a pair of hollow needles of differing length penetrating said needle-pierceable sealing means, whereby the needle tips are respectively positioned adjacent opposed walls of said housing exterior to said bag, one needle communicating with a source of aqueous drug diluent solution and the other needle communicating with means for receiving diluent solution having drug from said bag dissolved therein.

Claim 29

Dependent Claim 23 words

The cartridge of claim 22 in which one needle extends entirely through said bag and the other needle terminates short of said bag.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1992-05-22	1992-11-21	1993-05-23	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1996-05-22	1996-11-21	1997-05-23	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2000-05-22	2000-11-21	2001-05-23	$7700.00	Window Closed / Lapsed

Needle-pierceable cartridge for drug delivery

Abstract

Inventors

Bibliographic Details

Claims Analysis

References Cited (Backward Citations)

USPTO Annuity & Maintenance Windows

Assigned Categories & Tags

Assign Category Tag