US4432756A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Parenteral controlled therapy
Assignee: Alza Corp
•
Filing: 1981-11-27
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Granted: 1984-02-21
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Expires: 2001-11-27
Abstract
Abstract A parenteral delivery set is disclosed for administering a beneficial agent to a recipient. The set comprises (a) a primary container of a medical fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medical fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber connected to the secondary tubing and housing an agent dispensing device or the beneficial agent; and (f) a common tubing in communication with the primary tubing and the secondary tubing for communicating the set to the recipient.
Inventors
- 👤 John Urquhart
- 👤 Felix Theeuwes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:16
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/1407; A61M5/142; A61M5/145; A61M2005/14513
Claims Analysis
Total Claims: 47
Claim 1
Independent Claim
200 words
A parenteral delivery set for administering a beneficial fluid and a beneficial agent formulation to an animal, the set comprising: (a) a primary tube for the flow of a parenterally acceptable fluid therethrough; (b) a secondary tube for the flow of a parenterally acceptable fluid therethrough; (c) a formulation chamber in communication with the secondary tube, the formulation chamber comprising: (1) a wall surrounding a lumen; (2) an inlet for letting fluid from the secondary tube into the formulation chamber; (3) a beneficial agent in the formulation chamber that forms an agent formulation with fluid that enters the formulation chamber; (4) a release rate controlling membrane in the formulation chamber, said membrane formed of a polymeric material that governs the rate of release of agent formulation from the formulation chamber; (5) an outlet for letting an agent formulation leave the formulation chamber; and, (d) a common tube in communication with the primary tube for receiving fluid from the primary tube, and in communication with the secondary tube for receiving agent formulation from the secondary tube, which common tube, when the set is in use is in communication with the animal, administers the beneficial fluid and the beneficial agent formulation thereto.
Claim 2
Dependent Claim
200 words
A parenteral delivery set for administering a beneficial fluid and a beneficial agent formulation to an animal, the set comprising: (a) a primary tube for the flow of a parenterally acceptable fluid therethrough; (b) a secondary tube for the flow of a parenterally acceptable fluid therethrough; (c) a formulation chamber in communication with the secondary tube, the formulation chamber comprising: (1) a wall surrounding a lumen; (2) an inlet for letting fluid from the secondary tube into the formulation chamber; (3) a beneficial agent in the formulation chamber that forms an agent formulation with fluid that enters the formulation chamber; (4) a release rate controlling membrane in the formulation chamber, said membrane formed of a polymeric material that governs the rate of release of agent formulation from the formulation chamber; (5) an outlet for letting an agent formulation leave the formulation chamber; and, (d) a common tube in communication with the primary tube for receiving fluid from the primary tube, and in communication with the secondary tube for receiving agent formulation from the secondary tube, which common tube, when the set is in use is in communication with the animal, administers the beneficial fluid and the beneficial agent formulation thereto.
Claim 3
Dependent Claim
23 words
The parenteral delivery set according to claim 1, wherein the set comprises a flow regulator on the primary tube for governing flow therethrough.
Claim 4
Dependent Claim
23 words
The parenteral delivery set according to claim 1, wherein the set comprises a flow regulator on the secondary tube for governing flow therethrough.
Claim 5
Dependent Claim
27 words
The parenteral delivery set according to claim 1, wherein the set comprises a valve in communication with the primary tube, the secondary tube and the common tube.
Claim 6
Dependent Claim
44 words
The parenteral delivery set according to claim 1, wherein the set comprises a valve in communication with the primary tube, the secondary tube and the common tube, and which valve is adjustable for establishing fluid communication between the primary tube and the common tube.
Claim 7
Dependent Claim
46 words
The parenteral delivery set according to claim 1, wherein the set comprises a valve in communication with the primary tube, the secondary tube and the common tube, and which valve is adjustable for permitting agent formulation to flow from the secondary tube into the common tube.
Claim 8
Dependent Claim
22 words
The parenteral delivery set according to claim 1, wherein the set comprises a drip chamber in fluid communication with the primary tube.
Claim 9
Dependent Claim
22 words
The parenteral delivery set according to claim 1, wherein the set comprises a drip chamber in fluid communication with the secondary tube.
Claim 10
Dependent Claim
18 words
The parenteral delivery set according to claim 1, wherein the set comprises a filter in the formulation chamber.
Claim 11
Dependent Claim
20 words
The parenteral delivery set according to claim 1, wherein the beneficial agent in the formulation chamber is in tablet form.
Claim 12
Dependent Claim
20 words
The parenteral delivery set according to claim 1, wherein the beneficial agent in the formulation chamber is in lypohilized form.
Claim 13
Dependent Claim
20 words
The parenteral delivery set according to claim 1, wherein a skin piercing member is in communication with the common tube.
Claim 14
Dependent Claim
15 words
The parenteral delivery set according to claim 1, wherein the beneficial agent is a drug.
Claim 15
Dependent Claim
210 words
A parenteral delivery system for the administration of a beneficial fluid and a beneficial agent formulation to a patient, the system comprising: (a) a primary container of a medically acceptable fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medically acceptable fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber in fluid communication with the secondary tubing, the formulation chamber comprising: (1) a wall that surrounds a lumen; (2) an inlet that communicates with the secondary tubing for letting fluid into the formulation chamber; (3) a beneficial agent in the formulation chamber that forms an agent formulation with fluid that enters the formulation chamber; (4) a beneficial agent release rate controlling membrane in the formulation chamber, said membrane formed of a polymeric material that governs the rate of agent formulation release from the formulation chamber; (5) an outlet for letting an agent formulation leave the chamber; and, (f) a common tubing in communication with the primary tubing for receiving fluid from the primary tubing, and in communication with the secondary tubing for receiving agent formulation from the secondary tubing, which common tubing is attachable to a skin piercing member for communicating with the patient.
Claim 16
Dependent Claim
210 words
A parenteral delivery system for the administration of a beneficial fluid and a beneficial agent formulation to a patient, the system comprising: (a) a primary container of a medically acceptable fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medically acceptable fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber in fluid communication with the secondary tubing, the formulation chamber comprising: (1) a wall that surrounds a lumen; (2) an inlet that communicates with the secondary tubing for letting fluid into the formulation chamber; (3) a beneficial agent in the formulation chamber that forms an agent formulation with fluid that enters the formulation chamber; (4) a beneficial agent release rate controlling membrane in the formulation chamber, said membrane formed of a polymeric material that governs the rate of agent formulation release from the formulation chamber; (5) an outlet for letting an agent formulation leave the chamber; and, (f) a common tubing in communication with the primary tubing for receiving fluid from the primary tubing, and in communication with the secondary tubing for receiving agent formulation from the secondary tubing, which common tubing is attachable to a skin piercing member for communicating with the patient.
Claim 17
Dependent Claim
20 words
The parenteral delivery system according to claim 14, wherein the system comprises a drip chamber connected to the primary tube.
Claim 18
Dependent Claim
20 words
The parenteral delivery system according to claim 14, wherein the system comprises a drip chamber connected to the secondary tubing.
Claim 19
Dependent Claim
20 words
The parenteral delivery system according to claim 14, wherein the system comprises a flow control regulator on the primary tubing.
Claim 20
Dependent Claim
20 words
The parenteral delivery system according to claim 14, wherein the system comprises a flow control regulator on the secondary tubing.
Claim 21
Dependent Claim
29 words
The parenteral delivery system according to claim 14, wherein the system comprises a valve that is in communication with the primary tubing, the secondary tubing and the common tubing.
Claim 22
Dependent Claim
44 words
The parenteral delivery set according to claim 14, wherein the set comprises a valve in communication with the primary tubing, the secondary tubing and the common tubing, and which valve is adjustable for permitting fluid flow between the primary tubing and the common tubing.
Claim 23
Dependent Claim
46 words
The parenteral delivery set according to claim 14, wherein the set comprises a valve in communication with the primary tubing, the secondary tubing and the common tubing, and which valve is adjustable for permitting agent formulation to flow from the secondary tube into the common tube.
Claim 24
Dependent Claim
16 words
The parenteral delivery system according to claim 14, wherein the beneficial agent is in tablet form.
Claim 25
Dependent Claim
17 words
The parenteral delivery system according to claim 14, wherein the beneficial agent is in a lypholizied form.
Claim 26
Dependent Claim
15 words
The parenteral delivery system according to claim 16, wherein the beneficial agent is a drug.
Claim 27
Independent Claim
275 words
A method for administering a beneficial agent and a parenteral fluid to a warm-blooded animal, the method comprising: (a) admitting parenterally into an animal in need of a beneficial agent, a delivery member in communication with a parenteral delivery system, the system comprising: (1) a primary container of a parenterally acceptable fluid; (2) a primary tube in fluid communication with the primary container for the flow of fluid therethrough; (3) a secondary container of a parenterally acceptable fluid; (4) a secondary tube in fluid communication with the secondary container for the flow of fluid therethrough; (5) a formulation chamber connected to the secondary tube, the formulation chamber comprising: (i) a wall that surrounds a lumen; (ii) an inlet that communicates with the secondary tube for letting fluid into the formulation chamber; (iii) a beneficial agent in the formulation chamber, which agent forms an agent solution with fluid that enters the formulation chamber; (iv) a release rate controlling membrane in the formulation chamber, said membrane formed of a polymeric material that governs the rate of agent formulation release from the formulation chamber; (v) an outlet for letting the agent solution leave the formulation chamber; (6) a valve in communication with the primary tube and in communication with the secondary tube; (7) a common tube in communication with the valve and in communication with the delivery member; and wherein, (b) agent is administered to the animal by positioning the valve to let agent solution flow from the secondary tube into the common tube, and (c) fluid is administered to the animal by positioning the valve to let fluid flow from the primary tube into the common tube.
Claim 28
Independent Claim
275 words
A method for administering a beneficial agent and a parenteral fluid to a warm-blooded animal, the method comprising: (a) admitting parenterally into an animal in need of a beneficial agent, a delivery member in communication with a parenteral delivery system, the system comprising: (1) a primary container of a parenterally acceptable fluid; (2) a primary tube in fluid communication with the primary container for the flow of fluid therethrough; (3) a secondary container of a parenterally acceptable fluid; (4) a secondary tube in fluid communication with the secondary container for the flow of fluid therethrough; (5) a formulation chamber connected to the secondary tube, the formulation chamber comprising: (i) a wall that surrounds a lumen; (ii) an inlet that communicates with the secondary tube for letting fluid into the formulation chamber; (iii) a beneficial agent in the formulation chamber, which agent forms an agent solution with fluid that enters the formulation chamber; (iv) a release rate controlling membrane in the formulation chamber, said membrane formed of a polymeric material that governs the rate of agent formulation release from the formulation chamber; (v) an outlet for letting the agent solution leave the formulation chamber; (6) a valve in communication with the primary tube and in communication with the secondary tube; (7) a common tube in communication with the valve and in communication with the delivery member; and wherein, (b) agent is administered to the animal by positioning the valve to let agent solution flow from the secondary tube into the common tube, and (c) fluid is administered to the animal by positioning the valve to let fluid flow from the primary tube into the common tube.
Claim 29
Dependent Claim
37 words
The method for administering the beneficial agent and the parenteral fluid according to claim 25, wherein the agent is administered continuously to the animal by regulating the valve to let agent solution continuously leave the secondary tube.
Claim 30
Dependent Claim
45 words
The method for administering the beneficial agent and the parenteral fluid periodically to the animal according to claim 25 wherein the valve is alternatively regulated to let fluid flow through the primary tube and then regulated to let agent solution flow through the secondary tube.
Claim 31
Dependent Claim
206 words
A parenteral delivery set for administering a beneficial fluid and a beneficial agent formulation to an animal, the set comprising: (a) a primary tube for the flow of a parenterally acceptable fluid therethrough; (b) a secondary tube for the flow of a parenterally acceptable fluid therethrough; (c) a formulation chamber in the secondary tube, the formulation chamber comprising: (1) a wall surrounding a lumen; (2) an inlet for letting fluid from the secondary tube into the formulation chamber; (3) means for automatically constituting a beneficial agent formulation in the formulation chamber, said means a beneficial agent delivery device for releasing at a rate controlled by the device a therapeutically effective amount of a beneficial agent that forms a beneficial agent formulation with parenteral fluid that enters the formulation chamber; (4) a beneficial agent in the means; (5) an outlet for letting a beneficial agent formulation leave the formulation chamber; and, (d) a common tube in communication with the primary tube for receiving fluid from the primary tube, and in communication with the secondary tube for receiving agent formulation from the secondary tube, which common tube, when the set is in use in communication with the animal, administers the beneficial agent and the beneficial agent formulation thereto.
Claim 32
Dependent Claim
206 words
A parenteral delivery set for administering a beneficial fluid and a beneficial agent formulation to an animal, the set comprising: (a) a primary tube for the flow of a parenterally acceptable fluid therethrough; (b) a secondary tube for the flow of a parenterally acceptable fluid therethrough; (c) a formulation chamber in the secondary tube, the formulation chamber comprising: (1) a wall surrounding a lumen; (2) an inlet for letting fluid from the secondary tube into the formulation chamber; (3) means for automatically constituting a beneficial agent formulation in the formulation chamber, said means a beneficial agent delivery device for releasing at a rate controlled by the device a therapeutically effective amount of a beneficial agent that forms a beneficial agent formulation with parenteral fluid that enters the formulation chamber; (4) a beneficial agent in the means; (5) an outlet for letting a beneficial agent formulation leave the formulation chamber; and, (d) a common tube in communication with the primary tube for receiving fluid from the primary tube, and in communication with the secondary tube for receiving agent formulation from the secondary tube, which common tube, when the set is in use in communication with the animal, administers the beneficial agent and the beneficial agent formulation thereto.
Claim 33
Dependent Claim
22 words
The parenteral delivery set according to claim 28, wherein the set comprises a drip chamber in fluid communication with the formulation chamber.
Claim 34
Dependent Claim
22 words
The parenteral delivery set according to claim 28, wherein the set comprises a drip chamber in fluid communication with the primary tube.
Claim 35
Dependent Claim
22 words
The parenteral delivery set according to claim 28, wherein the set comprises a drip chamber in fluid communication with the secondary tube.
Claim 36
Dependent Claim
15 words
The parenteral delivery set according to claim 28, wherein the beneficial agent is a drug.
Claim 37
Dependent Claim
61 words
The parenteral delivery set according to claim 28, wherein the set comprises a valve in communication with the primary tube, the secondary tube, and the common tube, and which valve is adjustable for establishing fluid communication between the primary tube and the common path, and is adjustable for permitting agent formulation to flow from the secondary path into the common path.
Claim 38
Dependent Claim
23 words
The parenteral delivery set according to claim 28, wherein the set comprises a flow regulator on the primary tube for governing flow therethrough.
Claim 39
Dependent Claim
23 words
The parenteral delivery set according to claim 28, wherein the set comprises a flow regulator on the secondary path for governing flow therethrough.
Claim 40
Dependent Claim
22 words
The parenteral delivery set according to claim 28, wherein the set comprises a skin piercing member in communication with the commom path.
Claim 41
Dependent Claim
223 words
A parenteral delivery system for the administration of a beneficial fluid and a beneficial agent formulation to a patient, the system comprising: (a) a primary container of a medically acceptable fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medically acceptable fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber in fluid communication with the secondary tubing, the formulation chamber comprising: (1) a wall that surrounds a lumen; (2) an inlet that communicates with the secondary tubing for letting fluid into the formulation chamber; (3) means for automatically constituting a beneficial agent formulation in the formulation chamber, said means a rate controlled dosage delivery form that delivers at a rate controlled by the form, a therapeutically effective amount of a beneficial agent that constitutes a beneficial agent formulation with fluid that enters the formulation chamber; (4) a dosage amount of a beneficial agent in the dosage delivery form; (5) an outlet for letting an agent formulation leave the chamber; and, (f) a common tubing in communication with the primary tubing for receiving fluid from the primary tubing, and in communication with the secondary tubing for receiving agent fromulation from the secondary tubing, which common tubing is attachable to a skin piercing member for communicating with the patient.
Claim 42
Dependent Claim
223 words
A parenteral delivery system for the administration of a beneficial fluid and a beneficial agent formulation to a patient, the system comprising: (a) a primary container of a medically acceptable fluid; (b) a primary tubing in fluid communication with the primary container; (c) a secondary container of a medically acceptable fluid; (d) a secondary tubing in fluid communication with the secondary container; (e) a formulation chamber in fluid communication with the secondary tubing, the formulation chamber comprising: (1) a wall that surrounds a lumen; (2) an inlet that communicates with the secondary tubing for letting fluid into the formulation chamber; (3) means for automatically constituting a beneficial agent formulation in the formulation chamber, said means a rate controlled dosage delivery form that delivers at a rate controlled by the form, a therapeutically effective amount of a beneficial agent that constitutes a beneficial agent formulation with fluid that enters the formulation chamber; (4) a dosage amount of a beneficial agent in the dosage delivery form; (5) an outlet for letting an agent formulation leave the chamber; and, (f) a common tubing in communication with the primary tubing for receiving fluid from the primary tubing, and in communication with the secondary tubing for receiving agent fromulation from the secondary tubing, which common tubing is attachable to a skin piercing member for communicating with the patient.
Claim 43
Dependent Claim
22 words
The parenteral delivery system according to claim 37, wherein the system comprises a drip chamber in fluid communication with the primary tube.
Claim 44
Dependent Claim
22 words
The parenteral delivery system according to claim 37, wherein the system comprises a drip chamber in fluid communication with the secondary tube.
Claim 45
Dependent Claim
19 words
The parenteral delivery system according to claim 37, wherein the system comprises a flow control on the primary tubing.
Claim 46
Dependent Claim
19 words
The parenteral delivery system according to claim 37, wherein the system comprises a flow control on the secondary tubing.
Claim 47
Dependent Claim
29 words
The parenteral delivery system according to claim 37, wherein the system comprises a valve that is in communication with the primary tubing, the secondary tubing and the common tubing.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-02-20 | 1987-08-22 | 1988-02-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-02-20 | 1991-08-22 | 1992-02-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-02-20 | 1995-08-22 | 1996-02-21 | $7700.00 | Window Closed / Lapsed |