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US3921636A Expired / Lapsed US ⏱️ 0.0 years remaining

Novel drug delivery device

Assignee: Alza Corp
•
Filing: 1974-04-22
•
Granted: 1975-11-25
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Expires: 1994-04-22
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Abstract

Abstract A drug delivery device for administering drug at a controlled rate for a prolonged period of time is disclosed. The device comprises a plurality of reservoirs containing drug distributed through a matrix. The reservoirs and the matrix are formed of materials permeable to passage of drug. The rate of drug permeation (release) from the reservoir is lower than the rate of permeation through the matrix so that release from the reservoir is the drug release rate controlling step.

Inventors

  • 👤 Alejandro Zaffaroni

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 14:36
CPC Classifications
A; A61; A61F; A61F13/00; A61F13/15; A61F13/84; A61F6/00; A61F6/06; A61F6/14; A61K; A61K9/00; A61K9/0012; A61K9/0034; A61K9/0036; A61K9/0039; A61K9/14; A61K9/16; A61K9/1605; A61K9/1629; A61K9/1652; A61K9/20; A61K9/2072; A61K9/2077; A61K9/2081; A61K9/48; A61K9/50; A61K9/5005; A61K9/5021; A61K9/5036; A61K9/5042; A61M; A61M31/00; A61M31/002; A61F13/20; A61F13/2002; A61F13/202; A61F13/2051; A61F13/2074; A61F13/8405; A61F2013/15008; A61F2013/15048; A61F2013/15113

Claims Analysis

Total Claims: 15
Claim 1
Independent Claim 178 words
A drug delivery device which releases drug continuously at a controlled rate over a prolonged period of time when administered to an animal comprising: a. a plurality of reservoirs each comprising i. a drug confined within ii. a drug release rate controlling material permeable to the drug by diffusion, microporous flow or a combination thereof, said drug release rate controlling material being essentially insoluble in body fluids and essentially non-crushable under the conditions of administration and, with the proviso that if said drug is highly water soluble, substantially impermeable to body fluids; dispersed in b. a matrix formed of a material permeable to said drug at a rate greater than the rate of permeability of the drug through said drug release rate controlling material so that the rate of drug permeation through said drug release rate controlling material determines the rate of release of drug from the device; whereby when the device is administered said reservoirs remain intact and release drug by diffusion, microporous flow or a combination thereof continuously at a controlled rate for said prolonged period.
Claim 2
Dependent Claim 178 words
A drug delivery device which releases drug continuously at a controlled rate over a prolonged period of time when administered to an animal comprising: a. a plurality of reservoirs each comprising i. a drug confined within ii. a drug release rate controlling material permeable to the drug by diffusion, microporous flow or a combination thereof, said drug release rate controlling material being essentially insoluble in body fluids and essentially non-crushable under the conditions of administration and, with the proviso that if said drug is highly water soluble, substantially impermeable to body fluids; dispersed in b. a matrix formed of a material permeable to said drug at a rate greater than the rate of permeability of the drug through said drug release rate controlling material so that the rate of drug permeation through said drug release rate controlling material determines the rate of release of drug from the device; whereby when the device is administered said reservoirs remain intact and release drug by diffusion, microporous flow or a combination thereof continuously at a controlled rate for said prolonged period.
Claim 3
Dependent Claim 29 words
The drug delivery device in accordance with claim 1 wherein the reservoir material is essentially imperforate and is permeable to the passage of drug by the process of diffusion.
Claim 4
Dependent Claim 14 words
The drug delivery device in accordance with claim 2 wherein the reservoirs are fibers.
Claim 5
Dependent Claim 14 words
The drug delivery device in accordance with claim 2 wherein the reservoirs are microcapsules.
Claim 6
Dependent Claim 43 words
The drug delivery device in accordance with claim 4 wherein the rate at which the drug permeates the matrix is in the range of from 10 to 2 times as great as the rate at which the drug diffuses through the reservoir material.
Claim 7
Dependent Claim 31 words
The drug delivery device in accordance with claim 1 wherein the reservoir material is microporous and is permeable to the passage oF drug by microporous flow through fluid in the micropores.
Claim 8
Dependent Claim 14 words
The drug delivery device in accordance with claim 6 wherein the reservoirs are fibers.
Claim 9
Dependent Claim 14 words
The drug delivery device in accordance with claim 6 wherein the reservoirs are microcapsules.
Claim 10
Dependent Claim 19 words
The drug delivery device in accordance with claim 8 wherein the fluid in the micropores is a body fluid.
Claim 11
Dependent Claim 20 words
The drug delivery device in accordance with claim 8 wherein the fluid in the micropores is a specifically added material.
Claim 12
Dependent Claim 18 words
The drug delivery device in accordance with claim 1 wherein said reservoirs are distributed homogeneously through said matrix.
Claim 13
Dependent Claim 18 words
The drug delivery device in accordance with claim 4 wherein said microcapsules are distributed homogeneously throughout the matrix.
Claim 14
Dependent Claim 34 words
An intrauterine drug delivery device comprising a matrix of silicone elastomer having a plurality of drug reservoirs dispersed therethrough, the reservoirs comprising progesterone particles each microencapsulated within a drug release rate controlling polyethylene wall.
Claim 15
Dependent Claim 34 words
An intrauterine drug delivery device comprising a matrix of silicone elastomer having a plurality of drug reservoirs dispersed therethrough, the reservoirs comprising progesterone particles each microencapsulated within a drug release rate controlling polyethylene wall.

References Cited (Backward Citations)

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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1978-11-24 1979-05-26 1979-11-25 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1982-11-24 1983-05-26 1983-11-25 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1986-11-24 1987-05-26 1987-11-25 $7700.00 Window Closed / Lapsed

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