US4806252A — Plasma collection set and method

Claim 1

Independent Claim 197 words

A method of separating a selected component from a fluid within a sealed system, a collection container of which is rotated in a centrifuge while another portion of which remains stationary, the method comprising: providing a centrifuge; providing a sealed fluid collection system with a fluid filled collection container having an interior collection volume into which extends a selectively oriented barrier member; inserting the fluid filled collection container into a receiving chamber of the centrifuge; rotating the collection container at a predetermined rotational velocity thereby separating the selected component from the remaining fluid in the container by forcing the remaining fluid into an outer annular region adjacent a rotating peripheral wall of the chamber while simultaneously collecting the separated component in an inner, adjacent annular region thereby emptying a central region of the container; reducing the rotational velocity of the collection container and fluid therein and blocking movement of the fluid in the container with respect thereto by means of the barrier member so as to minimize mixing of the separated selected component with the remaining fluid; and withdrawing a selected portion of fluid from the rotating collection container and into the stationary portion of the system.

Claim 2

Independent Claim 197 words

A method of separating a selected component from a fluid within a sealed system, a collection container of which is rotated in a centrifuge while another portion of which remains stationary, the method comprising: providing a centrifuge; providing a sealed fluid collection system with a fluid filled collection container having an interior collection volume into which extends a selectively oriented barrier member; inserting the fluid filled collection container into a receiving chamber of the centrifuge; rotating the collection container at a predetermined rotational velocity thereby separating the selected component from the remaining fluid in the container by forcing the remaining fluid into an outer annular region adjacent a rotating peripheral wall of the chamber while simultaneously collecting the separated component in an inner, adjacent annular region thereby emptying a central region of the container; reducing the rotational velocity of the collection container and fluid therein and blocking movement of the fluid in the container with respect thereto by means of the barrier member so as to minimize mixing of the separated selected component with the remaining fluid; and withdrawing a selected portion of fluid from the rotating collection container and into the stationary portion of the system.

Claim 3

Dependent Claim 21 words

A method as in claim 1 including collapsing a central portion of the collection container as the central region is emptying.

Claim 4

Dependent Claim 36 words

A method as in claim 2 including sensing the location of an interface between the separated component and the remaining fluid and initiating the withdrawing step when the interface has been sensed at a predetermined location.

Claim 5

Dependent Claim 22 words

A method as in claim 2 including rotating the collection container for a predetermined period of time before initiating the withdrawing step.

Claim 6

Dependent Claim 18 words

A method as in claim 2 wherein the withdrawn selected portion of fluid corresponds to the separated component.

Claim 7

Dependent Claim 33 words

A method as in claim 5 wherein the withdrawing step includes pumping the separated component into a stationary container of the system while continuously rotating the collection container at the reduced rotational velocity.

Claim 8

Dependent Claim 15 words

A method as in claim 1 wherein the provided centrifuge is a dual member centrifuge.

Claim 9

Independent Claim 162 words

A method of separating first and second selected components from a quantity of fluid comprising: providing a fluid flow transfer set having first and second disk-shaped containers in fluid flow communication and a third container in fluid flow communication with the first and second containers; providing a centrifuge; filling the first disk-shaped container with a predetermined quantity of fluid; placing the first and second containers in a rotatable receiving chamber of the centrifuge; interposing a radially extending barrier into the first container; rotating the chamber so as to effect separation of the first and second components from a residual fluid component; withdrawing the first and second separated components from the first disk-shaped container without remixing them with the residual fluid component and at least partially filling the second disk-shaped container with same; rotating the receiving chamber and separating the first and second components from one another; and withdrawing one of the separated components from the second disk-shaped container into the third container.

Claim 10

Independent Claim 162 words

A method of separating first and second selected components from a quantity of fluid comprising: providing a fluid flow transfer set having first and second disk-shaped containers in fluid flow communication and a third container in fluid flow communication with the first and second containers; providing a centrifuge; filling the first disk-shaped container with a predetermined quantity of fluid; placing the first and second containers in a rotatable receiving chamber of the centrifuge; interposing a radially extending barrier into the first container; rotating the chamber so as to effect separation of the first and second components from a residual fluid component; withdrawing the first and second separated components from the first disk-shaped container without remixing them with the residual fluid component and at least partially filling the second disk-shaped container with same; rotating the receiving chamber and separating the first and second components from one another; and withdrawing one of the separated components from the second disk-shaped container into the third container.

Claim 11

Dependent Claim 26 words

A method as in claim 8 including infusing a selected nutritive solution from the third container into the residual fluid component in the first disk-shaped container.

Claim 12

Dependent Claim 17 words

A method as in claim 9 including separating the containers from one another and sealing each container.

Claim 13

Dependent Claim 14 words

A method as in claim 8 wherein the centrifuge is a dual member centrifuge.

Claim 14

Dependent Claim 20 words

A method as in claim 11 including forming a radially extending barrier member in at least said first disk-shaped container.

Claim 15

Dependent Claim 19 words

A method as in claim 11 including forming a radially extending barrier member in each of said disk-shaped containers.

Claim 16

Dependent Claim 165 words

A fluid collection set, usable in the collection of a quantity of fluid, and positionable in part in a receiving chamber of a centrifuge for the purpose of separating, by centrifugation, a selected fluid component, the set comprising: a flexible, disk-shaped collection container defining an interior collection volume in which a quantity of fluid can be collected with said collection container having a selectively curved, sealed periphery; a fluid flow conduit with a proximal end and a distal end, said proximal end in fluid flow communication with said interior collection volume; a separated component container in fluid flow communication with said distal end of said conduit with said disk-shaped collection container rotatable in the receiving chamber while simultaneously coupled to said component container so as to accumulate the component separated from the quantity of fluid rotated in the receiving chamber with said proximal end of said fluid flow conduit extending into said interior collection volume a predetermined amount thereby forming an elongated, radially extending barrier.

Claim 17

Dependent Claim 165 words

A fluid collection set, usable in the collection of a quantity of fluid, and positionable in part in a receiving chamber of a centrifuge for the purpose of separating, by centrifugation, a selected fluid component, the set comprising: a flexible, disk-shaped collection container defining an interior collection volume in which a quantity of fluid can be collected with said collection container having a selectively curved, sealed periphery; a fluid flow conduit with a proximal end and a distal end, said proximal end in fluid flow communication with said interior collection volume; a separated component container in fluid flow communication with said distal end of said conduit with said disk-shaped collection container rotatable in the receiving chamber while simultaneously coupled to said component container so as to accumulate the component separated from the quantity of fluid rotated in the receiving chamber with said proximal end of said fluid flow conduit extending into said interior collection volume a predetermined amount thereby forming an elongated, radially extending barrier.

Claim 18

Dependent Claim 179 words

A fluid collection set, usable in the collection of a quantity of fluid, and positionable in part in a receiving chamber of a centrifuge for the purpose of separating, by centrifugation, a selected fluid component, the set comprising: a flexible, disk-shaped collection container defining an interior collection volume in which a quantity of fluid can be collected with said collection container having a selectively curved, sealed periphery said collection container formed of first and second planar plastic members sealingly joined along said curved periphery; a fluid flow conduit with a proximal end and a distal end, said proximal end in fluid flow communication with said interior collection volume; a separated component container in fluid flow communication with said distal end of said conduit with said disk-shaped collection container rotatable in the receiving chamber while simultaneously coupled to said component container so as to accumulate the component separated from the quantity of fluid rotated in the receiving chamber with said proximal end of said fluid flow conduit extending into said collection container through a selected region of said circular periphery.

Claim 19

Dependent Claim 179 words

A fluid collection set, usable in the collection of a quantity of fluid, and positionable in part in a receiving chamber of a centrifuge for the purpose of separating, by centrifugation, a selected fluid component, the set comprising: a flexible, disk-shaped collection container defining an interior collection volume in which a quantity of fluid can be collected with said collection container having a selectively curved, sealed periphery said collection container formed of first and second planar plastic members sealingly joined along said curved periphery; a fluid flow conduit with a proximal end and a distal end, said proximal end in fluid flow communication with said interior collection volume; a separated component container in fluid flow communication with said distal end of said conduit with said disk-shaped collection container rotatable in the receiving chamber while simultaneously coupled to said component container so as to accumulate the component separated from the quantity of fluid rotated in the receiving chamber with said proximal end of said fluid flow conduit extending into said collection container through a selected region of said circular periphery.

Claim 20

Dependent Claim 183 words

A fluid collection set, usable in the collection of a quantity of whole blood, and positionable in part in a receiving chamber of a centrifuge for the purpose of separating, by centrifugation, a selected blood component, the set comprising: a flexible, plastic, disk-shaped collection container defining an interior collection volume in which a quantity of whole blood from a donor can be collected with said collection container having a curved periphery; a fluid flow conduit with a proximal end and a distal end, said proximal end in fluid flow communication with said interior collection volume; a separated component container in fluid flow communication with said distal end of said conduit with said disk-shaped collection container rotatable in the receiving chamber while simultaneously coupled to said component container so as to accumulate the component separated from the quantity of blood rotated in the receiving chamber with said proximal end of said fluid flow conduit extending into said collection volume a predetermined amount and attached to a region of the collection container thereby forming a radially extending barrier member positioned within said interior collection volume.

Claim 21

Dependent Claim 183 words

A fluid collection set, usable in the collection of a quantity of whole blood, and positionable in part in a receiving chamber of a centrifuge for the purpose of separating, by centrifugation, a selected blood component, the set comprising: a flexible, plastic, disk-shaped collection container defining an interior collection volume in which a quantity of whole blood from a donor can be collected with said collection container having a curved periphery; a fluid flow conduit with a proximal end and a distal end, said proximal end in fluid flow communication with said interior collection volume; a separated component container in fluid flow communication with said distal end of said conduit with said disk-shaped collection container rotatable in the receiving chamber while simultaneously coupled to said component container so as to accumulate the component separated from the quantity of blood rotated in the receiving chamber with said proximal end of said fluid flow conduit extending into said collection volume a predetermined amount and attached to a region of the collection container thereby forming a radially extending barrier member positioned within said interior collection volume.

Claim 22

Independent Claim 222 words

A system for separation of a component from a fluid comprising: means for centrifugation including a rotatable receiving chamber; a fluid collection set, usable in the collection of quantity of fluid, and positionable at least in part in said receiving chamber for the purpose of separating, by centrifugation, the selected fluid component, said set including, a flexible, disk-shaped collection container defining an interior collection volume in which the quantity of fluid can be collected with said collection container having a circular periphery, said collection container with the quantity of fluid positionable in said receiving chamber; a fluid flow conduit with a proximal end and a distal end, said proximal end in fluid flow communication with said interior collection volume; a separated component container in fluid flow communicatin with said distal end of said conduit with said disk-shaped collection container rotatable in the receiving chamber while simultaneously coupled to said component container so as to accumulate the component separated from the quantity of fluid rotated in said receiving chamber with said collection container formed of first and second planar plastic members sealingly joined along said circular periphery, a barrier member positioned within said collection container between said sealed planar plastic members, with said proximal end of said fluid flow conduit extending into said collection volume a predetermined amount thereby forming said barrier member.

Claim 23

Independent Claim 222 words

A system for separation of a component from a fluid comprising: means for centrifugation including a rotatable receiving chamber; a fluid collection set, usable in the collection of quantity of fluid, and positionable at least in part in said receiving chamber for the purpose of separating, by centrifugation, the selected fluid component, said set including, a flexible, disk-shaped collection container defining an interior collection volume in which the quantity of fluid can be collected with said collection container having a circular periphery, said collection container with the quantity of fluid positionable in said receiving chamber; a fluid flow conduit with a proximal end and a distal end, said proximal end in fluid flow communication with said interior collection volume; a separated component container in fluid flow communicatin with said distal end of said conduit with said disk-shaped collection container rotatable in the receiving chamber while simultaneously coupled to said component container so as to accumulate the component separated from the quantity of fluid rotated in said receiving chamber with said collection container formed of first and second planar plastic members sealingly joined along said circular periphery, a barrier member positioned within said collection container between said sealed planar plastic members, with said proximal end of said fluid flow conduit extending into said collection volume a predetermined amount thereby forming said barrier member.

Claim 24

Dependent Claim 17 words

A set as in claim 17 with said barrier formed as an elongated, generally radially extending member.

Claim 25

Dependent Claim 18 words

A system as in claim 17 with said distal end essentially non-rotatable with respect to said proximal end.

Claim 26

Dependent Claim 16 words

A system as in claim 19 with said separated component container positionable within said receiving chamber.

Claim 27

Dependent Claim 18 words

A system as in claim 19 with said separated component container fixedly positionable outside of said centrifugation means.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1992-02-21	1992-08-22	1993-02-21	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1996-02-21	1996-08-22	1997-02-21	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	2000-02-21	2000-08-22	2001-02-21	$7700.00	Window Closed / Lapsed

Plasma collection set and method

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