US4416654A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pheresis apparatus
Assignee: Haemonetics Corp
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Filing: 1981-09-03
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Granted: 1983-11-22
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Expires: 2001-09-03
Abstract
Abstract This invention relates to an improvement in two-port centrifuge bowls in which component yield is enhanced by utilizing the centrifuge bowl for eluttriation, as well as centrifugation. In a particular embodiment, platelet yield is improved by terminating flow of anticoagulated whole blood from the donor to the bowl and pumping low density fluid, preferably plasma, back into the bowl at a relatively high rate to elutriate centrifugally separated cells in the bowl.
Inventors
- 👤 Donald W. Schoendorfer
- 👤 Lee E. Hansen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:32
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3693; A61M1/14; A61M1/30; A61M1/301; A61M1/303; A61M1/3601; A61M1/3603; A61M1/3696; B; B04; B04B; B04B5/00; B04B5/04; B04B5/0442
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
101 words
Apparatus comprising: (a) a centrifuge; (b) an enclosed fractionation volume on said centrifuge; (c) an inlet and outlet port mounted on said centrifuge, the ports being in fluid communication with said fractionation volume; (d) receptacle means outside said centrifuge for collecting a first fractionated whole blood component from said outlet port; (e) pump means for (i) first causing whole blood to flow into said inlet port at a predetermined rate and (ii) secondly for causing a first fractionated component of whole blood to be recirculated to the inlet port of said centrifuge to elutriate the remaining contents in the fractionation volume.
Claim 2
Dependent Claim
101 words
Apparatus comprising: (a) a centrifuge; (b) an enclosed fractionation volume on said centrifuge; (c) an inlet and outlet port mounted on said centrifuge, the ports being in fluid communication with said fractionation volume; (d) receptacle means outside said centrifuge for collecting a first fractionated whole blood component from said outlet port; (e) pump means for (i) first causing whole blood to flow into said inlet port at a predetermined rate and (ii) secondly for causing a first fractionated component of whole blood to be recirculated to the inlet port of said centrifuge to elutriate the remaining contents in the fractionation volume.
Claim 3
Dependent Claim
13 words
The apparatus of claim 1 in which the first fractionated component is plasma.
Claim 4
Dependent Claim
50 words
The apparatus of claim 1 in which the pump means is initially deenergized just prior to the point in time when substantial quantity of a blood component being harvested has exited the outlet port and thereafter the pump means is energized to cause said first fractionated component to be recirculated.
Claim 5
Dependent Claim
27 words
The apparatus of claim 3 in which the pump means is thereafter deenergized when the majority of the blood component being harvested has exited the outlet port.
Claim 6
Dependent Claim
26 words
The apparatus of claim 4 in which opto-electronic means are utilized to determine when the majority of blood component being harvested has exited the outlet port.
Claim 7
Dependent Claim
33 words
The apparatus of claim 5 in which the pump means operates at a faster flow rate during elutriation then the rate used when whole blood is caused to flow into the inlet port.
Claim 8
Dependent Claim
17 words
The apparatus of claim 5 in which the opto-electronic means responds to light scattering from blood component.
Claim 9
Dependent Claim
19 words
The apparatus of claim 1 in which fluid flow during elutriation is substantially parallel to fluid flow during centrifugation.
Claim 10
Dependent Claim
26 words
The apparatus of claim 1 in which the centrifuge is a fixed volume bowl and the flow rate during elutriation is substantially greater than during collection.
Claim 11
Dependent Claim
116 words
Apparatus for fractionating whole blood into components thereof comprising: (a) a centrifuge; (b) an enclosed fractionation volume on said centrifuge; (c) an inlet and outlet port mounted on said centrifuge, the ports being in fluid communication with said fractionation volume; (d) first pump means for causing whole blood to flow into said inlet port at a predetermined rate; (e) receptacle means outside said centrifuge for collecting fractionated whole blood component from said outlet port; (f) second pump means for causing a first fractionated component of said whole blood to be recirculated to the inlet port of said centrifuge to elutriate the remaining contents in the fractionation volume, thereby achieving enhanced separation of component within said centrifuge.
Claim 12
Dependent Claim
116 words
Apparatus for fractionating whole blood into components thereof comprising: (a) a centrifuge; (b) an enclosed fractionation volume on said centrifuge; (c) an inlet and outlet port mounted on said centrifuge, the ports being in fluid communication with said fractionation volume; (d) first pump means for causing whole blood to flow into said inlet port at a predetermined rate; (e) receptacle means outside said centrifuge for collecting fractionated whole blood component from said outlet port; (f) second pump means for causing a first fractionated component of said whole blood to be recirculated to the inlet port of said centrifuge to elutriate the remaining contents in the fractionation volume, thereby achieving enhanced separation of component within said centrifuge.
Claim 13
Dependent Claim
15 words
The apparatus of claim 10 in which the recirculated component is substantially cell free plasma.
Claim 14
Dependent Claim
40 words
The apparatus of claim 10 in which the first pump means is deenergized just prior to the point in time when the platelets, separated from the whole blood, exit the outlet port and the second pump means is energized thereafter.
Claim 15
Dependent Claim
36 words
The apparatus of claim 12 in which the second pump is deenergized when the majority of platelets have exited the outlet port, and opto-electronic means are utilized to determine when the majority of platelets have exited.
Claim 16
Dependent Claim
20 words
The apparatus of claim 13 in which the opto-electronic means provides an electrical signal proportional to the opacity of material.
Claim 17
Dependent Claim
28 words
The apparatus of claim 10 in which the flow rate of the second pump means is at least twice the rate of the first pump means during collection.
Claim 18
Independent Claim
85 words
The method of increasing component yield from donated whole blood in a two-port centrifugation bowl wherein: (i) lower density component is separated in the bowl from higher density component in the bowl and the lower density component is displaced to a separate container; and (ii) the lower density component is returned to the bowl to elutriate the higher density components remaining in the bowl; and (iii) component with density between lower density component and higher density component is displaced out of the bowl and harvested.
Claim 19
Independent Claim
85 words
The method of increasing component yield from donated whole blood in a two-port centrifugation bowl wherein: (i) lower density component is separated in the bowl from higher density component in the bowl and the lower density component is displaced to a separate container; and (ii) the lower density component is returned to the bowl to elutriate the higher density components remaining in the bowl; and (iii) component with density between lower density component and higher density component is displaced out of the bowl and harvested.
Claim 20
Dependent Claim
16 words
The method of claim 16 wherein the components remaining in the bowl after (iii) are reinfused.
Claim 21
Dependent Claim
29 words
The method of claim 16 wherein the component is returned in (ii) at a higher flow rate than the rate at which whole blood was pumped into the bowl.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-21 | 1987-05-23 | 1987-11-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-21 | 1991-05-23 | 1991-11-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-21 | 1995-05-23 | 1995-11-22 | $7700.00 | Window Closed / Lapsed |