US4758424A — Medicament adsorbates of decongestants with compl…

Claim 1

Independent Claim 88 words

A medicament adsorbate which comprises: a complex magnesium aluminum silicate having the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ having sorbed therein a solution of medicament drug, wherein the medicament drug is a decongestant.

Claim 2

Dependent Claim 88 words

A medicament adsorbate which comprises: a complex magnesium aluminum silicate having the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ having sorbed therein a solution of medicament drug, wherein the medicament drug is a decongestant.

Claim 3

Dependent Claim 28 words

The medicament adsorbate of claim 1 wherein the decongestant is selected from the group of decongestants consisting of phenylephrine hydrochlride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride, ephedrine and mixtures thereof.

Claim 4

Dependent Claim 53 words

The medicament adsorbate of claim 1 wherein the medicament drug is present in an amount of about 1 to about 35% by weight and the complex magnesium aluminum silicate is present in an amount of about 65 to about 99% by weight, all percents herein are by weight percent of the medicament adsorbate.

Claim 5

Dependent Claim 21 words

The medicament adsorbate of claim 1 further comprising a solvent content up to about 20% by weight of the medicament adsorbate.

Claim 6

Dependent Claim 23 words

The medicament adsorbate of claim 1 further comprising a solvent content from about 2% to about 15% by weight of the medicament adsorbate.

Claim 7

Dependent Claim 123 words

A process for preparing a medicament adsorbate which comprises: (A) preparing a solution by dissolving the medicament drug in a solvent, (B) sorbing the medicament drug within a complex magnesium aluminum silicate having the following typical chemical analysis ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ by admixing the solution with the complex magnesium aluminum silicate to form a homogenous mass, and (C) recovering the medicament adsorbate, wherein the medicament drug is a decongestant.

Claim 8

Dependent Claim 123 words

A process for preparing a medicament adsorbate which comprises: (A) preparing a solution by dissolving the medicament drug in a solvent, (B) sorbing the medicament drug within a complex magnesium aluminum silicate having the following typical chemical analysis ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ by admixing the solution with the complex magnesium aluminum silicate to form a homogenous mass, and (C) recovering the medicament adsorbate, wherein the medicament drug is a decongestant.

Claim 9

Dependent Claim 27 words

The process of claim 6 wherein the decongestant is selected from the group of decongestants consisting of phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride, ephedrine and mixtures thereof.

Claim 10

Dependent Claim 23 words

The process of claim 6 which comprises employing about 10% to about 60% by weight solvent of the solution to prepare the solution.

Claim 11

Dependent Claim 26 words

The process of claim 6 wherein the mass is dried to a final solvent content of up to about 20% by weight of the medicament adsorbate.

Claim 12

Dependent Claim 27 words

The process of claim 6 wherein the mass is dried to a final solvent content of about 2% to about 15% by weight of the medicament adsorbate.

Claim 13

Dependent Claim 116 words

A medicated composition which comprises a pharmaceutically acceptable carrier and from about 1% to about 60% by weight of the final composition of a medicament adsorbate containing magnesium aluminum silicate having the following typical chemical analysis; ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ and from about 1% to about 40% by weight of the adsorbate of a medicament drug, wherein the medicament drug is a decongestant.

Claim 14

Dependent Claim 116 words

A medicated composition which comprises a pharmaceutically acceptable carrier and from about 1% to about 60% by weight of the final composition of a medicament adsorbate containing magnesium aluminum silicate having the following typical chemical analysis; ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ and from about 1% to about 40% by weight of the adsorbate of a medicament drug, wherein the medicament drug is a decongestant.

Claim 15

Dependent Claim 30 words

The medicated composition of claim 11 wherein the pharmaceutically acceptable carrier is selected from the group consisting of a lozenge, suspension, a tablet, toffee, nougat, chewy candy and chewing gum.

Claim 16

Dependent Claim 28 words

The medicated composition of claim 11 wherein the decongestant is selected from the group of decongestants consisting of phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedine hydrochloride, ephedrine and mixtures thereof.

Claim 17

Dependent Claim 124 words

A medicated confectionery product comprising: a bulking agent of up to about 99%; a therapeutically effective amount of a medicament adsorbate comprising a complex magnesium aluminum silicate which has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ having sorbed therein a medicament drug, said medicament adsorbate being admixed in the confectionery product, all percents herein are by weight of the medicated confectionery product, wherein the medicament drug is an decongestant.

Claim 18

Dependent Claim 124 words

A medicated confectionery product comprising: a bulking agent of up to about 99%; a therapeutically effective amount of a medicament adsorbate comprising a complex magnesium aluminum silicate which has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ having sorbed therein a medicament drug, said medicament adsorbate being admixed in the confectionery product, all percents herein are by weight of the medicated confectionery product, wherein the medicament drug is an decongestant.

Claim 19

Dependent Claim 29 words

The medicated confectionery product of claim 14, wherein the decongestant is selected from the group of decongestants consisting of phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseuodphendrine hydrochloride, ephedrine and mixtures thereof.

Claim 20

Dependent Claim 146 words

A medicated chewing gum product containing a therapeutically effective amount of medicament drug which comprises: a chewing gum composition in an amount up to about 99% comprising; a gum base, a sweetener, and a therapeutically effective amount of a medicament adsorbate comprising a complex magnesium aluminum silicate which has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ having sorbed therein a medicament drug, said medicament adsorbate being admixed in the chewing gum composition, wherein the medicament drug is a decongestant, all percents herein are by weight of the medicated chewing gum product.

Claim 21

Dependent Claim 146 words

A medicated chewing gum product containing a therapeutically effective amount of medicament drug which comprises: a chewing gum composition in an amount up to about 99% comprising; a gum base, a sweetener, and a therapeutically effective amount of a medicament adsorbate comprising a complex magnesium aluminum silicate which has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 29.5 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________ having sorbed therein a medicament drug, said medicament adsorbate being admixed in the chewing gum composition, wherein the medicament drug is a decongestant, all percents herein are by weight of the medicated chewing gum product.

Claim 22

Dependent Claim 30 words

The medicated chewing gum product of claim 16 wherein the decongestant is selected from the group of decongestants consisting of phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride, ephedrine and mixtures thereof.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1991-07-19	1992-01-18	1992-07-19	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1995-07-19	1996-01-18	1996-07-19	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1999-07-19	2000-01-18	2000-07-19	$7700.00	Window Closed / Lapsed

Medicament adsorbates of decongestants with complex magnesium aluminum silicate and their preparation

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