US4368197A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Zinc aminophylline and its use in the treatment of bronchospasms
Assignee: Research Corp
•
Filing: 1980-11-07
•
Granted: 1983-01-11
•
Expires: 2000-11-07
Abstract
Abstract There is disclosed zinc complexes of amine salts of theophylline. The preferred compound disclosed is the zinc complex of aminophylline. These compounds are useful as bronchodilators and have antibronchospasmotic activity. They are substantially insoluble and do not impart an unpleasant taste to oral formulations. In addition, they are storage stable. The compounds are prepared by reacting a water soluble simple zinc salt with the amine salt of theophylline at temperatures of from 60°-90° C. for about 8 to 16 hours.
Inventors
- 👤 Eli Shefter
- 👤 Francis X. Smith
- 👤 Mark J. Gardner
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 04:03
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
34 words
A compound represented by the formula ##STR2## wherein R and R' are each a primary monoamine or ammonia or taken together are a lower alkyl primary diamine having from 2 to 6 carbon atoms.
Claim 2
Dependent Claim
34 words
A compound represented by the formula ##STR2## wherein R and R' are each a primary monoamine or ammonia or taken together are a lower alkyl primary diamine having from 2 to 6 carbon atoms.
Claim 3
Dependent Claim
12 words
The compound of claim 1, which is the zinc complex of aminophylline.
Claim 4
Dependent Claim
27 words
A chewable tablet containing an amount of the zinc complex of aminophylline which can be used to effectively treat bronchospasms and pharmaceutically acceptable tabletting adjuvants and excipients.
Claim 5
Dependent Claim
27 words
A chewable tablet containing an amount of the zinc complex of aminophylline which can be used to effectively treat bronchospasms and pharmaceutically acceptable tabletting adjuvants and excipients.
Claim 6
Dependent Claim
32 words
A pharmaceutical suspension suitable for oral administration containing an amount of the zinc complex of aminophylline which can be used to effectively treat bronchospasms and pharmaceutically acceptable oral suspension adjuvants and excipients.
Claim 7
Dependent Claim
32 words
A pharmaceutical suspension suitable for oral administration containing an amount of the zinc complex of aminophylline which can be used to effectively treat bronchospasms and pharmaceutically acceptable oral suspension adjuvants and excipients.
Claim 8
Dependent Claim
26 words
A method of treating an asthmatic patient to relieve bronchospasms which comprises orally administering to said patient an effective amount of the composition of claim 3.
Claim 9
Dependent Claim
25 words
A method of treating asthmatic patients to relieve bronchospasms which comprises orally administering to said patient an effective amount of the composition of claim 4.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-01-10 | 1986-07-12 | 1987-01-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-01-10 | 1990-07-12 | 1991-01-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-01-10 | 1994-07-12 | 1995-01-11 | $7700.00 | Window Closed / Lapsed |