US4085214A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Stable pro-drug forms of theophylline
Assignee: Interx Research Corp
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Filing: 1976-10-18
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Granted: 1978-04-18
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Expires: 1996-10-18
Abstract
Abstract There is provided exceptionally stable and useful pro-drug forms of theophylline having the formula: ##STR1## wherein R represents a straight or branched phenylalkenyl group having 2-8 carbon atoms in the alkenyl portion. The compounds of this invention are useful in the treatment of asthma in warm-blooded animals. Upon administration, the compounds of this invention slowly go into solution and subsequently cleave prior to and/or during the absorption process, releasing theophylline in a sustained manner at a non-toxic, therapeutic level; that is, without the large blood level variations normally observed when theophylline per se is administered.
Inventors
- 👤 Takeru Higuchi
- 👤 Nicolae S. Bodor
- 👤 Yu-Neng Kuo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 08:41
CPC Classifications
C; C07; C07D; C07D473/00; C07D473/02; C07D473/04; C07D473/06; C07D473/08
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
24 words
A pro-theophylline compound of the formula: ##STR3## wherein R represents a straight or branched phenylalkenyl group having 2-8 carbon atoms in the alkenyl portion.
Claim 2
Dependent Claim
24 words
A pro-theophylline compound of the formula: ##STR3## wherein R represents a straight or branched phenylalkenyl group having 2-8 carbon atoms in the alkenyl portion.
Claim 3
Dependent Claim
6 words
The compound of claim 1: 7-(3-phenyl-propenoyl)-theophylline
Claim 4
Dependent Claim
6 words
The compound of claim 1: 7-(6-phenyl-hexen-2-oyl)-theophylline
Claim 5
Dependent Claim
6 words
The compound of claim 1: 7-(8-phenyl-octen-5-oyl)-theophylline
Claim 6
Dependent Claim
34 words
A method for inducing a non-toxic, sustained therapeuticcally effective release of theophylline in the bloodstream of a warm-blooded animal which comprises: orally administering thereto, a pharmaceutically effective amount of the compound of claim 1.
Claim 7
Dependent Claim
10 words
The method of claim 5, wherein said compound is: 7-(3-phenyl-propenoyl)-theophylline.
Claim 8
Dependent Claim
25 words
A pharmaceutical composition which comprises: (1) a pharmaceutically effective amount of the compound of claim 1 in combination with, (2) a pharmaceutically acceptable inert diluent.
Claim 9
Dependent Claim
10 words
A composition of claim 7, wherein said compound is: 7-(3-phenyl-propenoyl)-theophylline.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-17 | 1981-10-17 | 1982-04-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-17 | 1985-10-17 | 1986-04-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-17 | 1989-10-17 | 1990-04-18 | $7700.00 | Window Closed / Lapsed |