Purine derivatives having hypocholesterolemic activity

Abstract

Abstract PURINE DERIVATIIVES OF THE FORMULA: 1-(R5-CO-R4-),2-R3,4,5-(-C(-R1)=A-C(-R2)=N-)IMIDAZOLE WHEREIN A IS N OR N$O, R1 IS HYDROGEN, HALOGEN, HYDORYXL, MERCAPTO, LOWER ALKOXY, AR(LOWER)ALKOXY, LOWER AKYTHIO, AMINO, LLLOWER ALKYLAMINO, DI(LOWER)ALKYLAMINO, AR(LOWER)ALKYLAMINO, ACYLAMINO, HYDROXYAMINO, LOWER AKOXYAMINO, AR(LOWER) ALKOXYAMINO OR ARYLOXYAMINO, R2 AND R3 ARE EACH HYDROGEN, HALOGEN, HYDOXYL, MERCAPTO, AMINO, LOWER ALKYL, ARYL, LOWER ALKOXY, AR(LOWER)ALKOXY OR LOWER ALKYLTHIO, R4 IS LOWER ALKYLENE SUBSTITUTED WITH ONE OR MORE HYDROXYIS (BUT NO HYDROXYL GROUP BEING PRESENT AT THE CARBON ATOM ADJACENT TO THE RING NITROGEN ATOM) WHICH MAY BE PROTECTED WITH ACYL, LOWER OR HIGHER ALKOXY, A AR(LOWER)AKYL OR, WHEN A PAIR OF HYDROXYLS EXIST ON THE ALKYLENE GROUP, WHICH LOWER ALKYLIDENE OR AR(LOWER)ALKYLIDENE AND R5 IS HYDROXYL, LOWER OR HIGHER ALKOXY, AMINO, LOWER ALKYLAMINO OR DI(LOWER)ALKYLAMINO, AND THEIR SALTS, WHICH EXIBIT MAKED HYPOCHOLESTEROLEMIC ACTIVITY WHICH EXTREMELY LOW TOXICITY.

Inventors

• 👤 Y Saito
• 👤 M Hashimoto
• 👤 A Tensho
• 👤 T Kamiya
• 👤 H Seki

Bibliographic Details