Process for the preparation of medicament adsorbates

Claim 2

A process for preparing a medicament adsorbate which comprises: admixing a complex magnesium aluminum silicate with a medicament drug and a sufficient amount of solvent to dissolve the medicament drug and hydrate the complex magnesium aluminum silicate to form a swollen mass containing said drug in an adsorbed condition, said solvent having a water content of at least about 50% by weight of the solvent, drying the swollen mass to a final solvent content up to about 20% by weight of the medicament adsorbate, and recovering the medicament adsorbate.

Claim 3

The process of claim 1 wherein the solvent is present in an amount from about 1 to about 20 times the weight of the complex magnesium aluminum silicate.

Claim 4

The process of claim 1 wherein the swollen mass is dried to a final solvent content of about 2% to about 15% by weight of the medicament adsorbate.

Claim 5

The process of claim 1 which comprises: employing about 65% to about 99% by weight of complex magnesium aluminum silicate, and about 1% to about 35% by weight of medicament drug, all percents herein are by weight percent of the medicament adsorbate.

Claim 6

The process of claim 1 wherein the complex magnesium aluminum silicate has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 55 to 70 3.2 to 35 Magnesium oxide 2.9 to 25 0.17 to 12.5 Aluminum oxide 2.0 to 17 1 Ferric oxide 0.4 to 1.8 Calcium oxide 1.1 to 2.4 Sodium oxide 1.0 to 3.8 Potassium oxide 0.2 to 1.9 Ignition Loss 5.5 to 12.6 ______________________________________

Claim 7

The process of claim 1 wherein the complex magnesium aluminum silicate has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 35 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________

Claim 8

The process for preparing a medicament adsorbate which comprises: (A) preparing a blend by admixing a complex magnesium aluminum silicate with at least an equal weight of solvent to form a swollen complex magnesium aluminum silicate, (B) preparing a solution by dissolving the medicament drug in a solvent, (C) sorbing the medicament drug within the swollen complex magnesium aluminum silicate by admixing the blend with the solution to form a swollen mass having a homogenous consistency and a water content of at least about 50% by weight of the total solvent content, (D) drying the swollen mass to a final solvent content of up to about 20% by weight of the medicament adsorbate, (E) recovering the medicament adsorbate.

Claim 9

The process for preparing a medicament adsorbate which comprises: (A) preparing a blend by admixing a complex magnesium aluminum silicate with at least an equal weight of solvent to form a swollen complex magnesium aluminum silicate, (B) preparing a solution by dissolving the medicament drug in a solvent, (C) sorbing the medicament drug within the swollen complex magnesium aluminum silicate by admixing the blend with the solution to form a swollen mass having a homogenous consistency and a water content of at least about 50% by weight of the total solvent content, (D) drying the swollen mass to a final solvent content of up to about 20% by weight of the medicament adsorbate, (E) recovering the medicament adsorbate.

Claim 10

The process of claim 7 wherein the complex magnesium aluminum silicate has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 55 to 70 3.2 to 35 Magnesium oxide 2.9 to 25 0.17 to 12.5 Aluminum oxide 2.0 to 17 1 Ferric oxide 0.4 to 1.8 Calcium oxide 1.1 to 2.4 Sodium oxide 1.0 to 3.8 Potassium oxide 0.2 to 1.9 Ignition Loss 5.5 to 12.6 ______________________________________

Claim 11

The process of claim 7 wherein the complex magnesium aluminum silicate has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 35 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________

Claim 12

The process of claim 7 which comprises preparing the solution with solvent in an amount from about 10% to about 60% by weight of the complex magnesium aluminum silicate, and preparing the blend with solvent in an amount from about 1 to about 20 times the weight of the complex magnesium aluminum silicate.

Claim 13

The process of claim 7 wherein the swollen mass is dried to a final solvent content of about 2% to about 15% by weight of the medicament adsorbate.

Claim 14

The process for claim 7 which comprises: employing about 65% to about 99% by weight of complex magnesium aluminum silicate, and about 1% to about 35% by weight of medicament drug, all percents herein are by weight percent of the medicament adsorbate.

Claim 15

A process for preparing a medicament adsorbate which comprises: (A) preparing a solution by dissolving a medicament drug in an amount of solvent at least equal in weight to the amount of complex magnesium aluminum silicate said solvent having a water content of at least about 50% by weight of the solvent, (B) sorbing the medicament drug within a complex magnesium aluminum silicate by admixing the solution with the complex magnesium aluminum silicate to form a swollen homogenous mass, and (C) drying the swollen mass to a final solvent content of up to about 20% by weight of the medicament adsorbate, (D) recovering the swollen medicament adsorbate.

Claim 16

A process for preparing a medicament adsorbate which comprises: (A) preparing a solution by dissolving a medicament drug in an amount of solvent at least equal in weight to the amount of complex magnesium aluminum silicate said solvent having a water content of at least about 50% by weight of the solvent, (B) sorbing the medicament drug within a complex magnesium aluminum silicate by admixing the solution with the complex magnesium aluminum silicate to form a swollen homogenous mass, and (C) drying the swollen mass to a final solvent content of up to about 20% by weight of the medicament adsorbate, (D) recovering the swollen medicament adsorbate.

Claim 17

The process of claim 13 wherein the swollen mass is dried to a final solvent content of about 2% to about 20% by weight of the medicament adsorbate.

Claim 18

The process of claim 13 which comprises: employing about 65% to about 99% by weight of complex magnesium aluminum silicate, about 1% to about 35% by weight of medicament drug, about 0.05% to about 4% by weight of surfactant, all percents herein are by weight percent of the medicament adsorbate.

Claim 19

The process of claim 13 wherein the complex magnesium aluminum silicate has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 55 to 70 3.2 to 35 Magnesium oxide 2.9 to 25 0.17 to 12.5 Aluminum oxide 2.0 to 17 1 Ferric oxide 0.4 to 1.8 Calcium oxide 1.1 to 2.4 Sodium oxide 1.0 to 3.8 Potassium oxide 0.2 to 1.9 Ignition Loss 5.5 to 12.6 ______________________________________

Claim 20

The process of claim 13 wherein the complex magnesium aluminum silicate has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 35 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ingition Loss 5.5 to 12.6 ______________________________________

Claim 21

The process of claim 13 wherein the solvent is present in an amount from about 1 to about 20 times the weight of the complex magnesium aluminum silicate.