US4632822A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Magnesium trisilicate suitable for preparation of medicament adsorbates of antiasmatics
Assignee: Warner Lambert Co LLC
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Filing: 1985-12-19
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Granted: 1986-12-30
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Expires: 2005-12-19
Abstract
Abstract A medicament adsorbate containing a magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces, and having adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an antiasmatic.
Inventors
- 👤 David Peters
- 👤 John Denick, Jr.
- 👤 Anil K. Talwar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 09:17
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/141; A61K9/143
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
65 words
A medicament adsorbate which comprises magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces, and containing adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug wherein the medicament drug is selected from the group of antitasmatics consisting of aminophyline, epinephrine, theophylline, and mixtures thereof.
Claim 2
Dependent Claim
65 words
A medicament adsorbate which comprises magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces, and containing adsorbed therein from about 1% to about 20% by weight of the adsorbate of a medicament drug wherein the medicament drug is selected from the group of antitasmatics consisting of aminophyline, epinephrine, theophylline, and mixtures thereof.
Claim 3
Dependent Claim
25 words
The adsorbate of claim 1 wherein the medicament drug is present in the amount of about 5% to about 15% by weight of the adsorbate.
Claim 4
Dependent Claim
25 words
The adsorbate of claim 1 wherein the magnesium trisilicate has a surface area of about 440 m 2 /g to about 600 m 2 /g.
Claim 5
Dependent Claim
87 words
A process for preparing a medicament adsorbate which comprises dissolving a medicament drug wherein the medicament drug is selected from the group of antitasmatics consisting of aminophyline, epinephrine, theophylline, and mixtures thereof in solvent, admixing magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces therewith to prepare a mass having a homogenous consistency to enable migration of the medicament drug within the interstitial spaces of the magnesium trisilicate and recovering the medicament adsorbate product.
Claim 6
Dependent Claim
87 words
A process for preparing a medicament adsorbate which comprises dissolving a medicament drug wherein the medicament drug is selected from the group of antitasmatics consisting of aminophyline, epinephrine, theophylline, and mixtures thereof in solvent, admixing magnesium trisilicate having a surface area of at least 400 m 2 /g and having a flake-like structure with multiple interstitial spaces therewith to prepare a mass having a homogenous consistency to enable migration of the medicament drug within the interstitial spaces of the magnesium trisilicate and recovering the medicament adsorbate product.
Claim 7
Dependent Claim
44 words
The process of claim 4 which comprises employing about 15% to about 35% by weight solvent to prepare a granulated admixture containing the medicament drug and magnesium trisilicate adsorbate which is dried to a final moisture content of about 5% to about 20% weight.
Claim 8
Dependent Claim
36 words
The process of claim 4 which comprises employing about 30% to about 60% solvent by weight of the total composition to prepare a slurry and thereafter removing the solvent from the slurry to form a paste.
Claim 9
Dependent Claim
17 words
The process of claim 6 wherein the paste is dried and recovered as a free flowing powder.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-29 | 1990-06-30 | 1990-12-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-29 | 1994-06-30 | 1994-12-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-29 | 1998-06-30 | 1998-12-30 | $7700.00 | Window Closed / Lapsed |