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US4755387A
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Therapeutic particles
Assignee: Procter and Gamble Co
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Filing: 1985-03-21
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Granted: 1988-07-05
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Expires: 2005-03-21
Abstract
Abstract Therapeutic particles are disclosed which have a coating of a combination of lipids over the therapeutic agent. The lipid coating provides good stomach protection while providing good release of the therapeutic agent in the intestines.
Inventors
- 👤 Ghebre E. Tzeghai
- 👤 Paul D. Leis, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 17:49
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/5073; A61K9/5005; A61K9/5015
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
86 words
Therapeutic active particles comprising a therapeutic active having a lipid coating of a mixture of: (a) a lipid selected from the group consisting of glyceryl tristearate, glyceryl tripalmitate, monopalmityl distearyl triglyceride, dipalmityl monostearyl triglyceride and mixtures thereof; (b) a lipid selected from the group consisting of sorbitan tristearate, hexaglycerol hexapalmitate, hexaglycerol hexastearate, decaglycerol decapalmitate, decaglycerol decastearate and mixtures thereof, wherein the lipid coating comprises from about 3% to about 45% of the coated particle and the ratio of a:b is from about 1:9 to about 1:1.
Claim 2
Dependent Claim
86 words
Therapeutic active particles comprising a therapeutic active having a lipid coating of a mixture of: (a) a lipid selected from the group consisting of glyceryl tristearate, glyceryl tripalmitate, monopalmityl distearyl triglyceride, dipalmityl monostearyl triglyceride and mixtures thereof; (b) a lipid selected from the group consisting of sorbitan tristearate, hexaglycerol hexapalmitate, hexaglycerol hexastearate, decaglycerol decapalmitate, decaglycerol decastearate and mixtures thereof, wherein the lipid coating comprises from about 3% to about 45% of the coated particle and the ratio of a:b is from about 1:9 to about 1:1.
Claim 3
Dependent Claim
14 words
Thereapeutic active particles according to claim 1 wherein the therapeutic active is a nonsteroidal.
Claim 4
Dependent Claim
21 words
Therapeutic particles according to claim 2 wherein the lipid coating is from about 10% to about 30% of the coated particle.
Claim 5
Dependent Claim
21 words
Therapeutic active particles according to claim 2 wherein the coated particles are from about 0.3 to about 3 mm in diameter.
Claim 6
Dependent Claim
21 words
Therapeutic active particles according to claim 2 wherein the a lipid is glyceryl tristearate and the b lipid is sorbitan tristearate.
Claim 7
Dependent Claim
19 words
Therapeutic active particles according to claim 5 wherein the ratio of a:b is from about 1:4 to about 2:3.
Claim 8
Dependent Claim
13 words
Therapeutic active particles according to claim 6 wherein the therapeutic active is aspirin.
Claim 9
Dependent Claim
22 words
Therapeutic active particles according to claim 6 wherein the lipid coating is from about 10% to about 30% of the coated particle.
Claim 10
Dependent Claim
29 words
Therapeutic active particles according to claim 2 wherein the therapeutic active has a first coating of a polymeric enteric material and the lipid coating is over the polymeric material.
Claim 11
Dependent Claim
23 words
Therapeutic active particles according to claim 9 wherein the polymeric enteric coating is from about 3% to about 20% of the coated particle.
Claim 12
Dependent Claim
19 words
Therapeutic active particles according to claim 3 which has a polymeric enteric coating mixed in with the lipid coating.
Claim 13
Dependent Claim
26 words
A method of alleviating pain by ingesting particles of claim 1 wherein each particle contains from about 100 to about 650 milligrams of an analgesic active.
Claim 14
Dependent Claim
14 words
A method according to claim 12 wherein the particles are according to claim 2.
Claim 15
Dependent Claim
14 words
A method according to claim 12 wherein the particles are according to claim 5.
Claim 16
Dependent Claim
14 words
A method according to claim 12 wherein the particles are according to claim 7.
Claim 17
Dependent Claim
25 words
Therapeutic active granules according to claim 1 wherein the therapeutic active is selected from the group consisting of insulin, vitamins, mineral supplements and mixtures thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-07-05 | 1992-01-04 | 1992-07-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-07-05 | 1996-01-04 | 1996-07-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-07-05 | 2000-01-04 | 2000-07-05 | $7700.00 | Window Closed / Lapsed |