US4013784A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Delayed release pharmaceutical preparations
Assignee: Individual
•
Filing: 1974-10-02
•
Granted: 1977-03-22
•
Expires: 1994-10-02
Abstract
Abstract A novel delayed release pharmaceutical preparation which is free of added enzymes and thus is stable on storage is provided. The preparation comprises particles of the therapeutically effective agent, a water-soluble calcium salt, and, if desired, a filler material, stabilizer, and other additives uniformly embedded in a triglyceride of fatty acids with 12 to 18 carbon atoms, thereby forming a granular preparation of a grain size between about 0.1 mm. and about 1.0 mm. A process of producing such a preparation is also disclosed.
Inventors
- 👤 Peter Speiser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-28 21:16
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/20; A61K9/2004; A61K9/2013; A61K9/14; A61K9/16; A61K9/1605; A61K9/1617
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
146 words
A delayed release pharmaceutical preparation in granular form comprising intermixed particles of at least one orally administrable therapeutically active agent and a substantially non-toxic water-soluble calcium salt selected from the group consisting of calcium levulinate, calcium gluconate, calcium citrate and calcium chloride, at least part of said particles of said agent and said salt being enveloped by solidifying a melt of at least one triglyceride of a fatty acid of 12 to 18 carbon atoms, said salt being present in an amount to provide at least 11/2 moles of calcium ion for each mole of said triglyceride and forming a substantially insoluble calcium soap with the fatty acid produced upon hydrolysis of said triglyceride in the intestinal tract, the granules of said preparation being of a grain size between about 0.1 mm. and about 1.0 mm. and containing between about 1 and 50% of said agent.
Claim 2
Dependent Claim
146 words
A delayed release pharmaceutical preparation in granular form comprising intermixed particles of at least one orally administrable therapeutically active agent and a substantially non-toxic water-soluble calcium salt selected from the group consisting of calcium levulinate, calcium gluconate, calcium citrate and calcium chloride, at least part of said particles of said agent and said salt being enveloped by solidifying a melt of at least one triglyceride of a fatty acid of 12 to 18 carbon atoms, said salt being present in an amount to provide at least 11/2 moles of calcium ion for each mole of said triglyceride and forming a substantially insoluble calcium soap with the fatty acid produced upon hydrolysis of said triglyceride in the intestinal tract, the granules of said preparation being of a grain size between about 0.1 mm. and about 1.0 mm. and containing between about 1 and 50% of said agent.
Claim 3
Dependent Claim
24 words
The pharmaceutical preparation of claim 1, wherein the triglyceride is selected from the group consisting of trilaurin, trimyristin, tripalmitin, and mixtures of said triglycerides.
Claim 4
Dependent Claim
19 words
The pharmaceutical preparation of claim 1, wherein the fatty acid triglyceride is present in the form of its β-modification.
Claim 5
Dependent Claim
32 words
The pharmaceutical preparation of claim 1, wherein the proportion of therapeutically active agent and calcium salt to fatty acid triglyceride in the preparation is between about 5% and about 30% by volume.
Claim 6
Dependent Claim
56 words
The pharmaceutical preparation of claim 1, wherein the preparation is in the form of spherical pellets of a diameter between about 0.1 mm. and about 1 mm. and wherein the ratio of the particle size of the active agent to the size of the pellet is between about 1 : 20 and about 1 : 100.
Claim 7
Dependent Claim
12 words
The pharmaceutical preparation of claim 1, additionally containing physiologically inert filler materials.
Claim 8
Dependent Claim
25 words
The pharmaceutical preparation of claim 1, additionally containing physiologically inert filler materials, preserving agents, stabilizers, aroma imparting and taste improving agents, and disintegration promoting agents.
Claim 9
Dependent Claim
16 words
A delayed release pharmaceutical composition having the preparation of claim 1 enclosed in a gelatin capsule.
Claim 10
Dependent Claim
20 words
A delayed release pharmaceutical composition in readily disintegrating tablet form containing the preparation of claim 1 and conventional tabletting adjuvants.
Claim 11
Dependent Claim
30 words
A delayed release pharmaceutical composition in aqueous dispersion form containing the granules of the preparation of claim 1 suspended in an aqueous medium containing a physiologically compatible, viscosity increasing agent.
References Cited (Backward Citations)
US2793979A
Cited
US2805977A
Cited
US2875130A
Cited
US2987445A
Cited
US3062720A
Cited
US3146167A
Cited
US3400197A
Cited
US3629393A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-21 | 1980-09-20 | 1981-03-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-21 | 1984-09-20 | 1985-03-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-21 | 1988-09-20 | 1989-03-22 | $7700.00 | Window Closed / Lapsed |