Patent US4745105A successfully refreshed from Google Patents.
US4745105A
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US
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Low molecular weight heparin derivatives with improved permeability
Assignee: Miami University
•
Filing: 1986-08-20
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Granted: 1988-05-17
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Expires: 2006-08-20
Abstract
Abstract Low molecular weight heparin derivatives containing hydrophobic groups and exhibiting improved permeability are disclosed. Said derivatives exhibit anticoagulant activity and improved solubility in organic solvents.
Inventors
- 👤 Charles C. Griffin
- 👤 Kevin M. Foley
- 👤 Eduardo Amaya
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 09:45
CPC Classifications
C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075
Claims Analysis
Total Claims: 42
Claim 1
Independent Claim
20 words
An ester of low molecular weight heparin characterized by a butanol water (3:2) partition coefficient greater than 1×10 -4 .
Claim 2
Dependent Claim
20 words
An ester of low molecular weight heparin characterized by a butanol water (3:2) partition coefficient greater than 1×10 -4 .
Claim 3
Dependent Claim
21 words
An ester of claim 1 wherein the ester is prepared by reacting an acid chloride with the low molecular weight heparin.
Claim 4
Dependent Claim
15 words
An ester of claim 2 wherein more than 50% of the ester groups are aliphatic.
Claim 5
Dependent Claim
14 words
An ester of claim 3 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 6
Dependent Claim
15 words
An ester of claim 1 wherein more than 50% of the ester groups are aliphatic.
Claim 7
Dependent Claim
14 words
An ester of claim 5 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 8
Dependent Claim
20 words
An ester of low molecular weight heparin characterized by a relative permeability, as compared to heparin, of 1.6 or greater.
Claim 9
Dependent Claim
20 words
An ester of low molecular weight heparin characterized by a relative permeability, as compared to heparin, of 1.6 or greater.
Claim 10
Dependent Claim
21 words
An ester of claim 7 wherein the ester is prepared by reacting an acid chloride with the low molecular weight heparin.
Claim 11
Dependent Claim
14 words
An ester of claim 8 wherein a preponderance of the ester groups are aliphatic.
Claim 12
Dependent Claim
14 words
An ester of claim 9 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 13
Dependent Claim
15 words
An ester of claim 7 wherein more than 50% of the ester groups are aliphatic.
Claim 14
Dependent Claim
14 words
An ester of claim 11 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 15
Dependent Claim
29 words
An ester of low molecular weight heparin containing more than 0.1 ester groups per tetrasaccharide unit and having a butanol water (3:2) partition coefficient greater than 1×10 -4 .
Claim 16
Dependent Claim
29 words
An ester of low molecular weight heparin containing more than 0.1 ester groups per tetrasaccharide unit and having a butanol water (3:2) partition coefficient greater than 1×10 -4 .
Claim 17
Dependent Claim
21 words
An ester of claim 13 wherein the ester is prepared by reacting an acid chloride with the low molecular weight heparin.
Claim 18
Dependent Claim
15 words
An ester of claim 14 wherein more than 50% of the ester groups are aliphatic.
Claim 19
Dependent Claim
17 words
An aliphatic ester of low molecular weight heparin containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 20
Dependent Claim
17 words
An aliphatic ester of low molecular weight heparin containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 21
Dependent Claim
21 words
An ester of claim 16 wherein the ester is prepared by reacting an acid chloride with the low molecular weight heparin.
Claim 22
Dependent Claim
37 words
An ester of low molecular weight heparin formed by replacing the free hydroxyl groups of low molecular weight heparin with ester groups, said ester characterized by a butanol water (3:2) partition coefficient greater than 1×10 -4 .
Claim 23
Dependent Claim
37 words
An ester of low molecular weight heparin formed by replacing the free hydroxyl groups of low molecular weight heparin with ester groups, said ester characterized by a butanol water (3:2) partition coefficient greater than 1×10 -4 .
Claim 24
Dependent Claim
21 words
An ester of claim 18 wherein the ester is prepared by reacting an acid chloride with the low molecular weight heparin.
Claim 25
Dependent Claim
15 words
An ester of claim 19 wherein more than 50% of the ester groups are aliphatic.
Claim 26
Dependent Claim
14 words
An ester of claim 20 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 27
Dependent Claim
15 words
An ester of claim 18 wherein more than 50% of the ester groups are aliphatic.
Claim 28
Dependent Claim
14 words
An ester of claim 22 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 29
Dependent Claim
37 words
An ester of low molecular weight heparin formed by replacing the free hydroxyl groups of low molecular weight heparin with ester groups, said ester characterized by a relative permeability, as compared to heparin, of 1.6 or greater.
Claim 30
Dependent Claim
37 words
An ester of low molecular weight heparin formed by replacing the free hydroxyl groups of low molecular weight heparin with ester groups, said ester characterized by a relative permeability, as compared to heparin, of 1.6 or greater.
Claim 31
Dependent Claim
21 words
An ester of claim 24 wherein the ester is prepared by reacting an acid chloride with the low molecular weight heparin.
Claim 32
Dependent Claim
14 words
An ester of claim 25 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 33
Dependent Claim
15 words
An ester of claim 18 wherein more than 50% of the ester groups are aliphatic.
Claim 34
Dependent Claim
14 words
An ester of claim 27 containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 35
Dependent Claim
45 words
An ester of low molecular weight heparin formed by replacing the free hydroxyl groups of low molecular weight heparin with ester groups and containing more than 0.1 ester groups per tetrasaccharide unit and having a butanol water (3:2) partition coefficient greater than 1×10 -4 .
Claim 36
Dependent Claim
45 words
An ester of low molecular weight heparin formed by replacing the free hydroxyl groups of low molecular weight heparin with ester groups and containing more than 0.1 ester groups per tetrasaccharide unit and having a butanol water (3:2) partition coefficient greater than 1×10 -4 .
Claim 37
Dependent Claim
20 words
An ester of claim 29 wherein the ester is prepared by reacting an acid chloride with low molecular weight heparin.
Claim 38
Dependent Claim
15 words
An ester of claim 30 wherein more than 50% of the ester groups are aliphatic.
Claim 39
Dependent Claim
31 words
An aliphatic ester of heparin formed by replacing the free hydroxyl groups of low molecular weight heparin with ester groups, said ester containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 40
Dependent Claim
31 words
An aliphatic ester of heparin formed by replacing the free hydroxyl groups of low molecular weight heparin with ester groups, said ester containing more than 0.1 ester groups per tetrasaccharide unit.
Claim 41
Dependent Claim
20 words
An ester of claim 32 wherein the ester is prepared by reacting an acid chloride with low molecular weight heparin.
Claim 42
Dependent Claim
27 words
A pharmaceutically active composition comprising a pharmaceutically acceptable carrier or diluent and, as the pharmaceutically active component, a product as claimed in any one of claims 1-33.
References Cited (Backward Citations)
US3088868A
Cited
US2999049A
Cited
US3548052A
Cited
US3510561A
Cited
US3482014A
Cited
US3546338A
Cited
US3506642A
Cited
US3574832A
Cited
US3574831A
Cited
US3577534A
Cited
US3835112A
Cited
US4239754A
Cited
GB2002406A
Cited
US4281108A
Cited
US4440926A
Cited
US4331697A
Cited
US4510135A
Cited
US4533549A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-05-17 | 1991-11-16 | 1992-05-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-05-17 | 1995-11-16 | 1996-05-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-05-17 | 1999-11-16 | 2000-05-17 | $7700.00 | Window Closed / Lapsed |