Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
177 words
Esters of heparin, which are derived from heparin by replacement of the carboxyl groups of heparin by groups of the formula: ##STR13## in which R is hydrogen or methyl and A is hydrogen, methyl, phenyl, ##STR14## X representing chlorine, nitro, alkyl containing 1 to 4 carbon atoms or methoxy and Y representing hydrogen or chlorine, the replacement being a partial or total replacement when A is other than hydrogen, methyl or phenyl, and, when A is hydrogen, methyl or phenyl, the replacement being a partial replacement corresponding to a 10% to 90% esterification percentage of the carboxyl groups and the esters being selective esters wherein are esterified, partially or wholly, either only the carboxyl groups of the D-glucuronic acid linkages, only the carboxyl groups of the D-glucuronic acid and unsulfated L-iduronic acid linkages, only the carboxyl groups of the unsulfated L-iduronic acid and sulfated L-iduronic acid linkages, or only the carboxyl groups of the sulfated L-iduronic acid linkages, and the alkali metal, alkaline earth metal, magnesium, quaternary ammonium and triethylamine, pyridine and imidazole salts of said esters.
Claim 2
Dependent Claim
177 words
Esters of heparin, which are derived from heparin by replacement of the carboxyl groups of heparin by groups of the formula: ##STR13## in which R is hydrogen or methyl and A is hydrogen, methyl, phenyl, ##STR14## X representing chlorine, nitro, alkyl containing 1 to 4 carbon atoms or methoxy and Y representing hydrogen or chlorine, the replacement being a partial or total replacement when A is other than hydrogen, methyl or phenyl, and, when A is hydrogen, methyl or phenyl, the replacement being a partial replacement corresponding to a 10% to 90% esterification percentage of the carboxyl groups and the esters being selective esters wherein are esterified, partially or wholly, either only the carboxyl groups of the D-glucuronic acid linkages, only the carboxyl groups of the D-glucuronic acid and unsulfated L-iduronic acid linkages, only the carboxyl groups of the unsulfated L-iduronic acid and sulfated L-iduronic acid linkages, or only the carboxyl groups of the sulfated L-iduronic acid linkages, and the alkali metal, alkaline earth metal, magnesium, quaternary ammonium and triethylamine, pyridine and imidazole salts of said esters.
Claim 3
Dependent Claim
20 words
Heparin esters according to claim 1 wherein, in the groups of formula (I), R is hydrogen and A is ##STR15##
Claim 4
Dependent Claim
20 words
Heparin esters according to claim 1 which are non-selective esters in which A is other than hydrogen, methyl or phenyl.
Claim 5
Dependent Claim
26 words
Heparin esters according to claim 1 which are selective esters in which are esterified, partially or wholly, only the carboxyl groups of the D-glucuronic acid linkages.
Claim 6
Dependent Claim
31 words
Heparin esters according to claim 1 which are selective esters in which are esterified, partially or wholly, only the carboxyl groups of the D-glucuronic acid linkages and unsulfated L-iduronic acid linkages.
Claim 7
Dependent Claim
31 words
Heparin esters according to claim 1 which are selective esters in which are esterified, partially or wholly, only the carboxyl groups of the unsulfated L-iduronic acid and sulfated L-iduronic acid linkages.
Claim 8
Dependent Claim
27 words
Heparin esters according to claim 1 which are selective esters in which are esterified, partially or wholly, only the carboxyl groups of the sulfated L-iduronic acid linkages.
Claim 9
Dependent Claim
24 words
Alkali metal salts of esters according to claim 1, 2, 3, 4, 5, 6 or 7 in which the alkali metal cation is sodium.
Claim 10
Dependent Claim
26 words
Alkaline earth metal salts of esters according to claim 1, 2, 3, 4, 5, 6 or 7 in which the alkaline earth metal cation is calcium.
Claim 11
Dependent Claim
15 words
Magnesium salts of esters according to claim 1, 2, 3, 4, 5, 6 or 7.
Claim 12
Dependent Claim
26 words
Quaternary ammonium salts of esters according to claim 1, 2, 3, 4, 5, 6 or 7 in which the quaternary ammonium cation is the benzethonium cation.
Claim 13
Dependent Claim
57 words
A process for preparing the compounds according to claim 6 wherein an alcohol of the formula: ##STR16## wherein R and A have the same definition as in formula (I), is reacted with heparin in an aqueous medium having a pH of from 2 to 3 in the presence of a water-soluble condensation agent of the carbodiimide type.
Claim 14
Dependent Claim
58 words
A process for preparing the compounds according to claim 7 wherein an alcohol of the formula: ##STR17## in which R and a have the same definition as in formula (I), is reacted with heparin in an aqueous medium having a pH of from 3.5 to 4.5 in the presence of a water-soluble condensation agent of the carbodiimide type.
Claim 15
Dependent Claim
96 words
A process for preparing the compounds according to claim 4, in which: (a) a quaternary ammonium salt is reacted with heparin in an aqueous medium, the pH of which is between 3 and 4; and (b) the so obtained acid quaternary ammonium salt of heparin in which are salified, in addition to the sulfate groups, only the carboxyl groups of the D-glucuronic acid linkages is reacted with a halogen derivative of the formula: ##STR18## in which Hal is a chlorine, bromine or iodine atom and R and A have the same definition as in formula (I).
Claim 16
Dependent Claim
135 words
A process for preparing the compounds according to claim 5, in which: (a) a quaternary ammonium salt is reacted with heparin in an aqueous medium, the pH of which is from 2 to 2.5; (b) the carboxyl groups of the D-glucuronic acid and unsulfated L-iduronic acid linkages of the product so obtained are selectively neutralized by addition of a determined amount of quaternary ammonium hydroxide in a dimethylformamide medium; and (c) the so obtained acid quaternary ammonium salt of heparin in which are salified, in addition to the sulfate groups, only the carboxyl groups of the D-glucuronic acid and unsulfated L-iduronic acid linkages is reacted with a halogen derivative of the formula: ##STR19## in which Hal is a chlorine, bromine or iodine atom and R and A have the same definition as in formula (I).