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US4281108A Expired / Lapsed US ⏱️ 0.0 years remaining

Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained

Assignee: Hepar Industries Inc
•
Filing: 1980-06-02
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Granted: 1981-07-28
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Expires: 2000-06-02
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Abstract

Abstract The present invention relates to a process for obtaining low molecular weight heparins endowed with pharmacological and therapeutic properties of outstanding interest, starting from normal heparin. The said process is characterized in that it comprises the following steps: (a) acidification of normal heparin to obtain heparinic acid, (b) depolymerization of said heparinic acid by heating in autoclave in the presence of peroxides, to obtain a low molecular weight heparamine, (c) sulphation of said heparamine to obtain the corresponding low molecular weight heparin. A further object of the invention is the low molecular weight heparins, or LMW heparins, so obtained, and their utilization in the field of therapeutics.

Inventors

  • 👤 Fernando Fussi

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-25 07:05
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/70; A61K31/715; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075

Claims Analysis

Total Claims: 8
Claim 1
Independent Claim 68 words
A process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, comprising the following steps: (a) acidification of normal heparin to obtain heparinic acid, (b) depolymerization of said heparinic acid by heating in the presence of peroxides, to obtain a low molecular weight heparamine of molecular weight approximately 4000 D to 12,000 D, (c) sulphation of said heparamine to obtain the corresponding low molecular weight heparin.
Claim 2
Dependent Claim 68 words
A process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, comprising the following steps: (a) acidification of normal heparin to obtain heparinic acid, (b) depolymerization of said heparinic acid by heating in the presence of peroxides, to obtain a low molecular weight heparamine of molecular weight approximately 4000 D to 12,000 D, (c) sulphation of said heparamine to obtain the corresponding low molecular weight heparin.
Claim 3
Dependent Claim 14 words
A process according to claim 1, wherein said depolymerization takes place in an autoclave.
Claim 4
Dependent Claim 25 words
A process according to claim 1, wherein said sulphation takes place by treatment with sulphotrioxides of nitrogen-containing organic bases, in the presence of a base.
Claim 5
Dependent Claim 19 words
A process according to claim 3, wherein said base is the free nitrogen-containing bases corresponding to the said sulphotrioxide.
Claim 6
Dependent Claim 13 words
A process according to claim 3, wherein said base is an alkaline carbonate.
Claim 7
Dependent Claim 20 words
A process according to claim 1, wherein said sulphation takes place by treatment with chloro-sulphonic acid and nitrogen-containing organic bases.
Claim 8
Dependent Claim 15 words
A process according to claim 1 wherein the acidification is with a cation exchange resin.

References Cited (Backward Citations)

GB867064A Cited
US3247063A Cited
GB2002406A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1984-07-27 1985-01-26 1985-07-28 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1988-07-27 1989-01-26 1989-07-28 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1992-07-27 1993-01-26 1993-07-28 $7700.00 Window Closed / Lapsed

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