US4673686A
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US
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New substituted heterocyclic benzamides, methods of preparing them and their application as behavior modifiers
Assignee: Societe dEtudes Scientifiques et Industrielles de lIle de France SA
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Filing: 1985-08-26
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Granted: 1987-06-16
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Expires: 2005-08-26
Abstract
Abstract There are provided new substituted heterocyclic benzamides and derivatives thereof which provide modifications on the central nervous system.
Inventors
- 👤 Michel Thominet
- 👤 Jacques Acher
- 👤 Jean-Claude Monier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:44
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/14; A; A61; A61P; A61P1/00; A61P1/08; A61P25/00; A61P25/18; C07C; C07C309/00; C07C317/00; C07C323/00; C07C65/00; C07C65/21; C07C65/28; C07D207/08; C07D207/09; C07D403/00; C07D403/02
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
88 words
Substituted heterocyclic benzamides, their salts of addition with pharmacologically acceptable acids, their quaternary ammonium salts, their N-oxides and their optically active isomers, of formula (I): ##STR7## wherein: A is a single bond R 4 is a norbornyl or adamantyl group R 5 is a C 1-3 alkyl group R 1 is a sulfamoyl group or a, C 1-3 alkylsulfonyl group R 2 is a hydrogen or halogen atom, an amino group or is joined with R 1 to form an azimido group R 3 is a hydrogen atom.
Claim 2
Dependent Claim
88 words
Substituted heterocyclic benzamides, their salts of addition with pharmacologically acceptable acids, their quaternary ammonium salts, their N-oxides and their optically active isomers, of formula (I): ##STR7## wherein: A is a single bond R 4 is a norbornyl or adamantyl group R 5 is a C 1-3 alkyl group R 1 is a sulfamoyl group or a, C 1-3 alkylsulfonyl group R 2 is a hydrogen or halogen atom, an amino group or is joined with R 1 to form an azimido group R 3 is a hydrogen atom.
Claim 3
Dependent Claim
65 words
The substituted heterocyclic benzamides of claim 1 wherein: A is a single bond R 4 is a norbornyl or adamantyl group R 5 is a methyl group R 1 is a sulfamoyl group or a, C 1-2 alkylsulfonyl group R 2 is a hydrogen atom, an amino group or is joined with R 1 to form an azimido group R 3 is a hydrogen atom.
Claim 4
Dependent Claim
5 words
N-(1-adamantyl 2-pyrrolidinylmethyl) 2-methoxy 5-methylsulfonyl benzamide.
Claim 5
Dependent Claim
5 words
N-(1-adamantyl 2-pyrrolidinylmethyl) 2-methoxy 5-methylsulfonyl benzamide.
Claim 6
Dependent Claim
5 words
N-(1-adamantyl 2-pyrrolidinylmethyl) 2-methoxy 5-ethylsulfonyl benzamide.
Claim 7
Dependent Claim
5 words
N-(1-adamantyl 2-pyrrolidinylmethyl) 2-methoxy 5-ethylsulfonyl benzamide.
Claim 8
Dependent Claim
22 words
A pharmaceutical composition having anti-emetic activity which comprises the substituted heterocyclic benzamide of claim 1 or 2 and a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
30 words
A process for the treatment of nausea in patients which comprises administering an effective amount of the substituted heterocyclic benzamide of claim 1 or 2 and a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
4 words
N-(1-(2'-norbornyl)-2-pyrrolidinyl methyl) 2-methoxy-4-amino-5-ethylsulfonyl benzamide.
Claim 11
Dependent Claim
4 words
N-(1-(2'-norbornyl)-2-pyrrolidinyl methyl) 2-methoxy-4-amino-5-ethylsulfonyl benzamide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-06-15 | 1990-12-15 | 1991-06-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-06-15 | 1994-12-15 | 1995-06-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-06-15 | 1998-12-15 | 1999-06-16 | $7700.00 | Window Closed / Lapsed |