US4294828A
Expired / Lapsed
US
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New derivatives of 4-amino-5-alkyl sulphonyl orthoanisamides, methods of preparing them and their application as psychotropic agents
Assignee: Societe dEtudes Scientifiques et Industrielles de lIle de France SA
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Filing: 1979-01-18
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Granted: 1981-10-13
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Expires: 1999-01-18
Abstract
Abstract There are provided certain N-(1-lower alkyl-2-pyrrolidylmethyl)2-lower aly-4-amino-5-lower alkyl sulphonyl benzamides and derivatives thereof which provide surprising antiapomorphine and antiserotonin activity.
Inventors
- 👤 Michel Thominet
- 👤 Jacques Acher
- 👤 Jean-Claude Monier
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 07:18
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/08; C07D207/09; A; A61; A61P; A61P1/00; A61P1/08; A61P25/00; A61P43/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
102 words
A pharmaceutical composition having antiemetic or antiserotonin activity comprising an effective amount of a compound selected from the group consisting of 4-amino-5-alkylsulphonylortho-anisamides having the formula: ##STR6## wherein: R 1 is lower alkyl of 1 to 5 carbon atoms or lower alkenyl of 2 to 5 carbon atoms and R 2 and R 3 are lower alkyl of 1 to 5 carbon atoms, the N-oxides of said anisamides, the addition salts of said derivatives with pharmacologically acceptable acids, the quaternary ammonium salts of said derivatives and the levorotatory and dextrorotatory optical isomers of all of the foregoing compounds, and a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
102 words
A pharmaceutical composition having antiemetic or antiserotonin activity comprising an effective amount of a compound selected from the group consisting of 4-amino-5-alkylsulphonylortho-anisamides having the formula: ##STR6## wherein: R 1 is lower alkyl of 1 to 5 carbon atoms or lower alkenyl of 2 to 5 carbon atoms and R 2 and R 3 are lower alkyl of 1 to 5 carbon atoms, the N-oxides of said anisamides, the addition salts of said derivatives with pharmacologically acceptable acids, the quaternary ammonium salts of said derivatives and the levorotatory and dextrorotatory optical isomers of all of the foregoing compounds, and a pharmaceutically acceptable carrier.
Claim 3
Independent Claim
106 words
A method of treating patients having need of an antiemetic active substance which comprises administering to said patient an effective amount of a compound selected from the group consisting of 4-amino-5-alkylsulphonylortho-anisamides having the formula: ##STR7## wherein: R 1 is lower alkyl of 1 to 5 carbon atoms or lower alkenyl of 2 to 5 carbon atoms and R 2 and R 3 are lower alkyl of 1 to 5 carbon atoms, the N-oxides of said anisamides, the addition salts of said derivatives with pharmacologically acceptable acids, the quaternary ammonium salts of said derivatives and the levorotatory and dextrorotatory optical isomers of all of the foregoing compounds.
Claim 4
Independent Claim
106 words
A method of treating patients having need of an antiemetic active substance which comprises administering to said patient an effective amount of a compound selected from the group consisting of 4-amino-5-alkylsulphonylortho-anisamides having the formula: ##STR7## wherein: R 1 is lower alkyl of 1 to 5 carbon atoms or lower alkenyl of 2 to 5 carbon atoms and R 2 and R 3 are lower alkyl of 1 to 5 carbon atoms, the N-oxides of said anisamides, the addition salts of said derivatives with pharmacologically acceptable acids, the quaternary ammonium salts of said derivatives and the levorotatory and dextrorotatory optical isomers of all of the foregoing compounds.
Claim 5
Independent Claim
105 words
A method of treating patients having need of an antiserotonin active composition comprising administering to said patient an effective amount of a compound selected from the group consisting of 4-amino-5-alkylsulphonylortho-anisamides having the formula: ##STR8## wherein: R 1 is lower alkyl of 1 to 5 carbon atoms or lower alkenyl of 2 to 5 carbon atoms and R 2 and R 3 are lower alkyl of 1 to 5 carbon atoms, the N-oxides of said anisamides, the addition salts of said derivatives with pharmacologically acceptable acids, the quaternary ammonium salts of said derivatives and the levorotatory and dextrorotatory optical isomers of all of the foregoing compounds.
Claim 6
Independent Claim
105 words
A method of treating patients having need of an antiserotonin active composition comprising administering to said patient an effective amount of a compound selected from the group consisting of 4-amino-5-alkylsulphonylortho-anisamides having the formula: ##STR8## wherein: R 1 is lower alkyl of 1 to 5 carbon atoms or lower alkenyl of 2 to 5 carbon atoms and R 2 and R 3 are lower alkyl of 1 to 5 carbon atoms, the N-oxides of said anisamides, the addition salts of said derivatives with pharmacologically acceptable acids, the quaternary ammonium salts of said derivatives and the levorotatory and dextrorotatory optical isomers of all of the foregoing compounds.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-10-12 | 1985-04-13 | 1985-10-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-10-12 | 1989-04-13 | 1989-10-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-10-12 | 1993-04-13 | 1993-10-13 | $7700.00 | Window Closed / Lapsed |