US3959477A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Methods of protection against emesis in mammals by administration of a heterocyclic benzamide
Assignee: Societe dEtudes Scientifiques et Industrielles de lIle de France SA
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Filing: 1975-03-24
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Granted: 1976-05-25
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Expires: 1995-03-24
Abstract
Abstract The heterocyclic benzamides of this invention are particularly effective for the treatment of emesis in mammals. For example, when they are administered to dogs in relatively small dosage, they afford 100% protection against vomiting. They are also non-toxic in dosages for effecting complete control of vomiting.
Inventors
- 👤 Michel Leon Thominet
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 22:18
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/44; A61K31/445; C; C07; C07C; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C45/70; C07C45/71
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
85 words
A method of protection a mammal against emesis which comprises administering to said mammal an anti-emetic effective amount of a compound selected from the group consisting of a heterocyclic benzamide and its pharmaceutically acceptable acid addition salts and quaternary ammonium salts, said heterocyclic benzamide having the formula: ##SPC9## in which A is allyl or lower alkyl; R is allyl or lower alkyl; X is hydroxy; Y is halogen, m is a whole number less than 3 and n is a whole number less than 4.
Claim 2
Independent Claim
85 words
A method of protection a mammal against emesis which comprises administering to said mammal an anti-emetic effective amount of a compound selected from the group consisting of a heterocyclic benzamide and its pharmaceutically acceptable acid addition salts and quaternary ammonium salts, said heterocyclic benzamide having the formula: ##SPC9## in which A is allyl or lower alkyl; R is allyl or lower alkyl; X is hydroxy; Y is halogen, m is a whole number less than 3 and n is a whole number less than 4.
Claim 3
Dependent Claim
17 words
The method of claim 1 in which R of said compound is ethyl and m is 1.
Claim 4
Dependent Claim
15 words
The method of claim 1 in which said compound is a racemic form of N-(1-ethyl-2-pyrrolidylmethyl)-2-methoxy-4-hydroxy-5-chlorobenzamide.
Claim 5
Dependent Claim
16 words
The method of claim 1 in which said compound is in the levo or dextro form.
Claim 6
Dependent Claim
16 words
The method of claim 1 in which said compound is in the dextro form of N-(1-ethyl-2-pyrrolidylmethyl)-2-methoxy-4-hydroxy-5-chlorobenzamide.
Claim 7
Dependent Claim
15 words
The method of claim 1 in which said compound is the levo form of N-(1-ethyl-2-pyrrolidylmethyl)-2-methoxy-4-hydroxy-5-chlorobenzamide.
Claim 8
Dependent Claim
12 words
The method of claim 1 in which said compound is N-(1-ethyl-2-pyrrolidylmethyl)-2-methoxy-4-hydroxy-5-chlorobenzamide bromomethylate.
Claim 9
Dependent Claim
12 words
The method of claim 1 in which said compound is N-(1-propyl-2-pyrrolidylmethyl)-2-ethoxy-4-hydroxy-5-bromobenzamide hydrochloride.
References Cited (Backward Citations)
US3043874A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-25 | 1979-11-24 | 1980-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-25 | 1983-11-24 | 1984-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-25 | 1987-11-24 | 1988-05-25 | $7700.00 | Window Closed / Lapsed |