US4048321A
Expired / Lapsed
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Disubstituted azabicycloalkanes
Assignee: Science Union et Cie
•
Filing: 1976-05-13
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Granted: 1977-09-13
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Expires: 1996-05-13
Abstract
Abstract Disubstituted azabicycloalkanes of the formula ##STR1## wherein: N IS 0, 1 OR 2 R is saturated or unsaturated straight or branched (C 1 -C 5 ) aliphatic hydrocarbon, and X 1 , x 2 , x 3 , x 4 , x 5 , which are the same or different, are hydrogen, halogen, hydroxy, lower alkyl, lower alkoxy, trifluoromethyl, nitro, amino or sulfamoyl. These compounds are used as medicine especially in the treatment of gastroduodenal ulcers, gastric hypersecretion, nauseous syndromes of central origin and hypertension.
Inventors
- 👤 Laszlo Beregi
- 👤 Pierre Hugon
- 👤 Xavier Pascaud
- 👤 Jean-Claude Poignant
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 21:53
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/52; C07D209/44
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
8 words
A compound selected from the group consisting of:
Claim 2
Dependent Claim
8 words
A compound selected from the group consisting of:
Claim 3
Dependent Claim
83 words
A. Disubstituted azabicycloalkanes of the general formula I: ##STR12## wherein: n is 1; R is selected from the group consisting of saturated and unsaturated aliphatic hydrocarbon having from 1 to 5 carbon atoms inclusive in straight and branched chain, and, X 1 , x 2 , x 3 , x 4 and X 5 are each selected from the group consisting of hydrogen, halogen, hydroxy, alkyl and alkoxy each having from 1 to 5 carbon atoms inclusive, trifluoromethyl, nitro, amino, and sulfamoyl, and,
Claim 4
Dependent Claim
83 words
A. Disubstituted azabicycloalkanes of the general formula I: ##STR12## wherein: n is 1; R is selected from the group consisting of saturated and unsaturated aliphatic hydrocarbon having from 1 to 5 carbon atoms inclusive in straight and branched chain, and, X 1 , x 2 , x 3 , x 4 and X 5 are each selected from the group consisting of hydrogen, halogen, hydroxy, alkyl and alkoxy each having from 1 to 5 carbon atoms inclusive, trifluoromethyl, nitro, amino, and sulfamoyl, and,
Claim 5
Dependent Claim
7 words
B. Physiologically tolerable acid addition salts thereof.
Claim 6
Dependent Claim
7 words
B. Physiologically tolerable acid addition salts thereof.
Claim 7
Dependent Claim
12 words
A compound of claim 1, which is N-ethyl-2-(2-methoxy-5-sulfamoyl benzamido methyl)-3-azabicyclo (3,3,0) octane.
Claim 8
Dependent Claim
12 words
A compound of claim 1 which is N-allyl-2-(2-methoxy-5-sulfamoyl benzamido methyl)-3-azabicyclo (3,3,0) octane.
Claim 9
Dependent Claim
12 words
A compound of claim 1 which is N-ethyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo (3,3,0) octane.
Claim 10
Dependent Claim
12 words
A compound of claim 1, which is N-(2-methyl-2-propenyl)-2-(2-methoxy-5-sulfamoyl benzamido methyl)-3-azabicyclo (3,3,0) octane.
Claim 11
Dependent Claim
12 words
A compound of claim 1, which is N-ethyl-2-(2-methyl benzamido methyl)-3-azabicyclo (3,3,0) octane.
Claim 12
Dependent Claim
12 words
A compound of claim 1, which is N-ethyl-2-(2-amino benzamido methyl)-3-azabicyclo (3,3,0) octane.
Claim 13
Dependent Claim
12 words
A compound of claim 1, which is N-allyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo (3,3,0) octane.
Claim 14
Dependent Claim
26 words
A pharmaceutical composition containing as active principle a compound of claim 1 in an amount of 10 to 200 mg, together with a suitable pharmaceutical carrier.
Claim 15
Dependent Claim
18 words
A pharmaceutical composition of claim 9, wherein the amount of the active principle is 20 to 100 mg.
Claim 16
Dependent Claim
39 words
A method for treatiang a living animal body afflicted with a nauseous syndrome of central origin, comprising the step of administering an amount of a compound of claim 1, which is effective for the alleviation of the said condition.
References Cited (Backward Citations)
US3972994A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-09-12 | 1981-03-14 | 1981-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-09-12 | 1985-03-14 | 1985-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-09-12 | 1989-03-14 | 1989-09-13 | $7700.00 | Window Closed / Lapsed |