US4656031A
Expired / Lapsed
US
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Dentifrice compositions
Assignee: CPPD Inc A CORP OF
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Filing: 1985-05-07
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Granted: 1987-04-07
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Expires: 2005-05-07
Abstract
Abstract It is disclosed that a dentifrice which includes a surfactant and an anti-plaque agent comprising a substantially water-insoluble non-cationic antimicrobial agent or a zinc salt or a mixture thereof has enhanced activity when the dentifrice comprises at least 0.2% by weight of a lamellar liquid crystal surfactant phase having a lamellar spacing of less than 6.0 nm.
Inventors
- 👤 Roger M. Lane
- 👤 Derek M. C. Hull
- 👤 Charles A. Saxton
- 👤 Franciscus J. G. van der Ouderaa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 14:57
CPC Classifications
A; A61; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/46; A61K8/463; A61K8/02; A61K8/0295; A61K8/19; A61K8/27; A61K8/33; A61K8/34; A61K8/347; A61K8/36; A61K8/365; A61Q; A61Q11/00
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
236 words
A dentifrice composition, selected from the group consisting of a toothpaste, dental cream, or dental gel, effective to inhibit the growth of dental plaque comprising a surfactuant; a particulate abrasive agent in an amount of between about 5 and 60% by weight of the dentifrice composition; water in an amount between about 25 and 60% by weight of the dentifrice excluding insoluble solids; and an anti-plaque agent consisting of an effective amount of a substantially water-insoluble non-cationic antimicrobial agent or mixture thereof with a zinc salt having a water solubility greater than 2×10 -4 per 100 g of water at 25° C. and pH 7, characterized in that there is present in the dentifrice composition a lamellar liquid crystal surfactant phase having a lamellar spacing of less than 6.0 nm in an amount of at least about 0.2% by weight of the dentifrice composition, the lamellar spacing and percentage weight of the lamellar liquid crystal surfactant phase being measured after a centrifugation separation procedure, said separation procedure comprising: (1) sufficient centrifugation to separate the dentifrice composition into its main phases including a liquid portion; followed by (2) sufficient ultracentrifugation of the liquid portion so that the liquid portion separates into layers and there is no substantial change in the volumes of the separated layers of the liquid portion, the lamellar liquid crystal surfactant phase being present as one of the separated layers of the liquid portion.
Claim 2
Dependent Claim
236 words
A dentifrice composition, selected from the group consisting of a toothpaste, dental cream, or dental gel, effective to inhibit the growth of dental plaque comprising a surfactuant; a particulate abrasive agent in an amount of between about 5 and 60% by weight of the dentifrice composition; water in an amount between about 25 and 60% by weight of the dentifrice excluding insoluble solids; and an anti-plaque agent consisting of an effective amount of a substantially water-insoluble non-cationic antimicrobial agent or mixture thereof with a zinc salt having a water solubility greater than 2×10 -4 per 100 g of water at 25° C. and pH 7, characterized in that there is present in the dentifrice composition a lamellar liquid crystal surfactant phase having a lamellar spacing of less than 6.0 nm in an amount of at least about 0.2% by weight of the dentifrice composition, the lamellar spacing and percentage weight of the lamellar liquid crystal surfactant phase being measured after a centrifugation separation procedure, said separation procedure comprising: (1) sufficient centrifugation to separate the dentifrice composition into its main phases including a liquid portion; followed by (2) sufficient ultracentrifugation of the liquid portion so that the liquid portion separates into layers and there is no substantial change in the volumes of the separated layers of the liquid portion, the lamellar liquid crystal surfactant phase being present as one of the separated layers of the liquid portion.
Claim 3
Dependent Claim
23 words
A dentifrice composition as claimed in claim 1, wherein the lamellar spacing of the liquid crystal surfactant phase is less than 5.0 nm.
Claim 4
Dependent Claim
18 words
A dentifrice composition as claimed in claim 2, wherein the said lamellar spacing is less than 4.4 nm.
Claim 5
Dependent Claim
30 words
A dentifrice composition as claimed in claim 1, wherein said lamellar liquid crystal surfactant phase is present in an amount of at least 0.3% by weight of the dentifrice composition.
Claim 6
Dependent Claim
30 words
A dentifrice composition as claimed in claim 4, wherein said lamellar liquid crystal surfactant phase is present in an amount of at least 0.5% by weight of the dentifrice composition.
Claim 7
Dependent Claim
15 words
A dentifrice composition as claimed in claim 1, wherein the surfactant is an anionic surfactant.
Claim 8
Dependent Claim
30 words
A dentifrice composition as claimed in claim 6, wherein the surfactant is selected from the group consisting of sodium lauryl sulphate, sodium dodecylbenzene sulphonate, sodium lauroyl sarcosinate and mixtures thereof.
Claim 9
Dependent Claim
32 words
A dentifrice composition as claimed in claim 1, wherein the particulate abrasive agent is selected from alumina and silica abrasives having a particle size in the range of 2 to 20 microns.
Claim 10
Dependent Claim
79 words
A dentifrice composition as claimed in claim 1, wherein in the formulation of the dentifrice there is also included as an ingredient from 0.1 to 3% by weight of sodium chloride or a water-soluble electrolyte salt, other than a fluorine-containing salt, in an equivalent molar cation concentration effective to reduce the lamellar spacing of the liquid crystal surfactant phase to below 6.0 nm, but in an amount insufficient to result in the destruction of the liqid crystal surfactant phase.
Claim 11
Dependent Claim
26 words
A dentifrice composition as claimed in claim 9, wherein in the fromulation of the toothpaste there is included 0.1 to 1% by weight of sodium chloride.
Claim 12
Dependent Claim
30 words
A dentifrice composition as claimed in claim 1, wherein the antimicrobial agent is selected from the group consisting of phenolic compounds, bisphenolic compounds, halogenated diphenyl ethers, benzoate esters and carbanilides.
Claim 13
Dependent Claim
24 words
A dentifrice composition as claimed in claim 1, wherein the antimicrobial agent has a solubility in water at 25° C. of less than 0.5%.
Claim 14
Dependent Claim
24 words
A dentifrice composition as claimed in claim 12, wherein the antimicrobial agent has a solubility in water at 25° C. of less than 0.1%.
Claim 15
Dependent Claim
14 words
A dentifrice composition as claimed in claim 11, wherein the antimicrobial agent is Triclosan.
Claim 16
Dependent Claim
23 words
A dentifrice composition as claimed in claim 1, wherein the antimicrobial agent is present in an amount of 0.01 to 5% by weight.
Claim 17
Dependent Claim
32 words
A dentifrice composition as claimed in claim 1, wherein the zinc salt has a water solubility greater than 1×10 -2 g per 100 g of water at 25° C. and pH 7.
Claim 18
Dependent Claim
32 words
A dentifrice composition as claimed in claim 1, wherein the zinc salt is a salt of an orgainic acid selected from mono-, di-, and tri-carboxylic acids, alphahydroxy carboxylic acids and amino acids.
Claim 19
Dependent Claim
15 words
A dentifrice composition as claimed in claim 17, wherein the zinc salt is zinc citrate.
Claim 20
Dependent Claim
31 words
A dentifrice composition as claimed in claim 1, wherein the zinc salt is present in such amount as to provide from 0.05 to 1.5% of zinc by weight of the composition.
Claim 21
Dependent Claim
30 words
A dentifrice composition as claimed in claim 1, comprising 0.05 to 3% Triclosan, 0.3% to 1.5% zinc citrate, 0.2 to 1% sodium chloride and 1 to 3% sodium lauryl sulphate.
Claim 22
Dependent Claim
112 words
A dentifrice composition as claimed in claim 1, comprising agout 1% to about 3% by weight of an anionic surfactant selected from the group consisting of sodium lauryl sulphate, sodium dodecylbenzene sulphonate, sodium lauroyl sarcosinate and mixtures thereof, an anti-plaque agent consisting of from about 0.01% to about 5% by weight Triclosan or a mixture of said Triclosan with about 0.2% to about 2% by weight zinc citrate, about 0.1% to about 3% by weight sodium chloride, about 5% to about 60% by weight of an abrasive selected from alumina and silica abrasives, about 15% to 70% by weight of sorbitol syrup and about 0.1% to 5% by weight of flavour oil.
Claim 23
Dependent Claim
22 words
A dentifrice composition as claimed in claim 1, wherein the lamellar spacing is measured within a month of manufacturing the dentifrice composition.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-06 | 1990-10-06 | 1991-04-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-06 | 1994-10-06 | 1995-04-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-06 | 1998-10-06 | 1999-04-07 | $7700.00 | Window Closed / Lapsed |