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Patent US4652448A successfully refreshed from Google Patents.
US4652448A
Expired / Lapsed
US
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Use of monoclonal antibodies against bacterial adhesins
Assignee: MGI Pharma Inc
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Filing: 1983-12-06
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Granted: 1987-03-24
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Expires: 2003-12-06
Abstract
Abstract Monoclonal antibodies specific for surface antigens of bacteria which act as adhesins between prokaryotic and eukaryotic cells and, in particular, K-99 pili, and methods for production thereof are described. These monoclonal antibodies may be used for the prophylactic and therapeutic treatment of diseases induced by adhesin-bearing pathogens in animals and humans, and for the diagnostic identification of adhesin-bearing bacteria.
Inventors
- 👤 Peter L. Sadowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:12
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/569; C; C07; C07K; C07K16/00; C07K16/12; C07K16/1203; C07K16/1228; C07K16/1232; G01N33/577; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
39 words
A method for preventing enterotoxin-induced diarrheal disease in animals, comprising: administering to an uninfected animal a prophylactically-effective amount of monoclonal antibodies against an Escherichia coli K-99 pilus adhesin, which adhesin mediates attachment of said E. coli to mucocutaneous tissue.
Claim 2
Independent Claim
39 words
A method for preventing enterotoxin-induced diarrheal disease in animals, comprising: administering to an uninfected animal a prophylactically-effective amount of monoclonal antibodies against an Escherichia coli K-99 pilus adhesin, which adhesin mediates attachment of said E. coli to mucocutaneous tissue.
Claim 3
Independent Claim
58 words
A method for preventing enterotoxin-induced diarrheal disease in animals, comprising: administering to an uninfected animal a prophylactically-effective amount of monoclonal antibodies against an Escherichia coli K-99 pilus adhesin, which adhesin mediates attachment of said E. coli to mucocutaneous tissue, wherein the antibodies against said adhesin are produced by hybridoma cell line 2BD4E4 having accession number ATCC No. HB8178.
Claim 4
Independent Claim
58 words
A method for preventing enterotoxin-induced diarrheal disease in animals, comprising: administering to an uninfected animal a prophylactically-effective amount of monoclonal antibodies against an Escherichia coli K-99 pilus adhesin, which adhesin mediates attachment of said E. coli to mucocutaneous tissue, wherein the antibodies against said adhesin are produced by hybridoma cell line 2BD4E4 having accession number ATCC No. HB8178.
Claim 5
Independent Claim
42 words
A method for treating animals infected with an enterotoxigenic adhesin-bearing Escherichia coli, comprising: administering to an infected animal a therapeutically-effective amount of monoclonal antibodies against an E. coli K99 pilus adhesin, which adhesin mediates attachment of said E. coli to mucocutaneous tissue.
Claim 6
Independent Claim
42 words
A method for treating animals infected with an enterotoxigenic adhesin-bearing Escherichia coli, comprising: administering to an infected animal a therapeutically-effective amount of monoclonal antibodies against an E. coli K99 pilus adhesin, which adhesin mediates attachment of said E. coli to mucocutaneous tissue.
Claim 7
Independent Claim
61 words
A method for treating animals infected with an enterotoxigenic adhesin-bearing Escherichia coli, comprising: administering to an infected animal a therapeutically-effective amount of monoclonal antibodies against an E. coli K99 pilus adhesin, which adhesin mediates attachment of said E. coli to mucocutaneous tissue, wherein the antibodies against said adhesin are produced by hybridoma cell line 2BD4E4 having accession number ATCC No. HB8178.
Claim 8
Independent Claim
61 words
A method for treating animals infected with an enterotoxigenic adhesin-bearing Escherichia coli, comprising: administering to an infected animal a therapeutically-effective amount of monoclonal antibodies against an E. coli K99 pilus adhesin, which adhesin mediates attachment of said E. coli to mucocutaneous tissue, wherein the antibodies against said adhesin are produced by hybridoma cell line 2BD4E4 having accession number ATCC No. HB8178.
Claim 9
Dependent Claim
14 words
The method according to claim 2 or 4 wherein said animal is a piglet.
Claim 10
Dependent Claim
14 words
The method according to claim 2 or 4 wherein said animal is a calf.
Claim 11
Dependent Claim
14 words
The method accordng to claim 2 or 4 wherein said animal is a lamb.
Claim 12
Dependent Claim
15 words
The method according to claim 2 or 4 wherein the monoclonal antibodies are administered orally.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-23 | 1990-09-22 | 1991-03-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-23 | 1994-09-22 | 1995-03-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-23 | 1998-09-22 | 1999-03-24 | $7700.00 | Window Closed / Lapsed |