US3907987A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Enteric disease vaccine
Assignee: University of Guelph
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Filing: 1972-05-25
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Granted: 1975-09-23
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Expires: 1992-05-25
Abstract
Abstract Preparation of and live bacterial vaccine from selected strains of Escherichia coli. The bacterial cells are treated with dilute formalin solutions (about 0.02 to about 0.08% v/v formalin) for a period to modify the bacteria without inactivation thereof. One preferred strain is EW1 serogroup of 0157. The vaccine has been found particularly effective in preventing the occurrence of enteric colibacillosis in newborn animals. A preferred technique is to vaccinate cows, recover the milk, and continually feed it as a milk replacer to the newborn during the susceptible period.
Inventors
- 👤 Michael R Wilson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 16:08
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/025; A61K39/0258; A23; A23K; A23K10/00; A23K10/20; A23K10/26; A23K10/28; A23K50/00; A23K50/30; A61K2039/55; A61K2039/552; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y02P; Y02P60/00; Y02P60/80; Y02P60/87; Y10; Y10S; Y10S424/00; Y10S424/823; Y10S424/825
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
49 words
A BACTERIA VACCINE FOR THE PREVENTION OR TREATMENT OF E. COLI INFECTIONS COMPRISING A LIVE STRAIN OR STRAINS OF E. COLI INCUBATED IN AND MODIFIED BY DILUTE SOLUTIONS OF ABOUT 0.02 TO ABOUT 0.08% V/V FORMULIN, TO GIVE AN ALTERED GROWTH PATTERN AND APPEARANCE, AND REDUCED VIALBLE CELL COUNT.
Claim 2
Dependent Claim
49 words
A BACTERIA VACCINE FOR THE PREVENTION OR TREATMENT OF E. COLI INFECTIONS COMPRISING A LIVE STRAIN OR STRAINS OF E. COLI INCUBATED IN AND MODIFIED BY DILUTE SOLUTIONS OF ABOUT 0.02 TO ABOUT 0.08% V/V FORMULIN, TO GIVE AN ALTERED GROWTH PATTERN AND APPEARANCE, AND REDUCED VIALBLE CELL COUNT.
Claim 3
Dependent Claim
25 words
The vaccine of claim 1 wherein the E. coli is selected from the strains EWl of 0157;KV17;P307 of 08;K87.88a,c and Al of 0149; K91, K88a,c:H10.
Claim 4
Dependent Claim
22 words
The vaccine of claim 1 wherein the viable cell count has been reduced approximately 2 to 7 log dilutions by the formalin.
Claim 5
Dependent Claim
8 words
The vaccine of claim 1 in lyophilized form.
Claim 6
Dependent Claim
15 words
The vaccine of claim 4 in dosage unit form of about 40 to 400 mg.
Claim 7
Dependent Claim
9 words
The vaccine of claim 1 containing broth medium constituents.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-09-22 | 1979-03-24 | 1979-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-09-22 | 1983-03-24 | 1983-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-09-22 | 1987-03-24 | 1987-09-23 | $7700.00 | Window Closed / Lapsed |