Patent US2937738A successfully refreshed from Google Patents.
US4237115A
Expired / Lapsed
US
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Method of immunization against enterotoxogenic infection by Escherichia coli
Assignee: Bactex Inc
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Filing: 1977-11-23
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Granted: 1980-12-02
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Expires: 1997-11-23
Abstract
Abstract There is provided a vaccine material capable of providing a substantial level of protection against infection by enterotoxogenic organisms of Escherichia coli. The protecting means comprises pili of the infecting organism. The protection is given either by administering the pili directly to the subject to be protected or to a pregnant female where protection of the newborn is desired. In the case of piglets, where there is substantially no transplacental transfer of immunity from mother to offspring, the pili are administered to mothers, who are then caused to feed the offspring to be protected, whereby the immunization is transferred via the colostrum of the mother.
Inventors
- 👤 Charles C. Brinton, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-30 23:38
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/02; A61K39/025; A61K39/0258; C; C07; C07K; C07K14/00; C07K14/195; C07K14/24; C07K14/245; C07K16/00; C07K16/12; C07K16/1203; C07K16/1228; C07K16/1232; A61K2039/545; A61K2039/55; A61K2039/552; A61K38/00; Y; Y02; Y02A; Y02A50/00; Y02A50/30; Y10; Y10S; Y10S424/00; Y10S424/825; Y10S435/00; Y10S435/82
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
111 words
A vaccine composition capable of raising the antibody level of pigs to a level sufficient to provide protection against neonatal porcine colibacillosis caused by a member of a first group of strains of piliated E. coli, comprising (a) pili previously separated from other E. coli organism components derived from at least one member of a second group of strains of piliated E. coli organisms wherein cells of organisms of said first group are agglutinable by serum containing antibodies against pili from said second group, said first group consisting of strains which may be the same as or different from the strains of said second group, and (b) a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
111 words
A vaccine composition capable of raising the antibody level of pigs to a level sufficient to provide protection against neonatal porcine colibacillosis caused by a member of a first group of strains of piliated E. coli, comprising (a) pili previously separated from other E. coli organism components derived from at least one member of a second group of strains of piliated E. coli organisms wherein cells of organisms of said first group are agglutinable by serum containing antibodies against pili from said second group, said first group consisting of strains which may be the same as or different from the strains of said second group, and (b) a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
52 words
A vaccine of claim 1 comprising pili derived from more than one member of the second group of strains wherein each of said members of said second group are capable of producing antibodies which will cause the cells of at least one member of said first group to agglutinate in their presence.
Claim 4
Dependent Claim
22 words
A composition of claim 1 wherein a strain of the second group is E. coli 987-5 (ATCC 31346) or 74-5208 (ATCC 31347).
Claim 5
Dependent Claim
20 words
A composition of claim 3 comprising 1-10 mg of pili of the second group per 10 ml of injectable vehicle.
Claim 6
Dependent Claim
12 words
A composition of claim 4 wherein the vehicle is physiologically acceptable saline.
Claim 7
Independent Claim
122 words
A method of protecting newborn piglets against neonatal porcine colibacillosis caused by a member of a predetermined first group of strains of piliated E. coli which comprises (a) administering pre-partum to pregnant sows a composition comprising pili derived from at least one member of a second group of strains of piliated E. coli organisms wherein cells of organisms of said first group are agglutinable by serum containing antibodies against pili from said strains which may be the same as or different from strains of said second group; said first group consisting of strains which may be the same as or different from the strains of said second group; (b) administering colostrum or milk derived postpartum from the aforesaid sows to newborn piglets.
Claim 8
Independent Claim
122 words
A method of protecting newborn piglets against neonatal porcine colibacillosis caused by a member of a predetermined first group of strains of piliated E. coli which comprises (a) administering pre-partum to pregnant sows a composition comprising pili derived from at least one member of a second group of strains of piliated E. coli organisms wherein cells of organisms of said first group are agglutinable by serum containing antibodies against pili from said strains which may be the same as or different from strains of said second group; said first group consisting of strains which may be the same as or different from the strains of said second group; (b) administering colostrum or milk derived postpartum from the aforesaid sows to newborn piglets.
Claim 9
Dependent Claim
26 words
A method of claim 6 wherein the vaccine composition is administered at least once to the pregnant sows between about 5 and about 30 days pre-partum.
Claim 10
Dependent Claim
23 words
A method of claim 7 wherein there is administered between 1 and 100 μg/Kg body weight of the pilic component of vaccine composition.
Claim 11
Dependent Claim
29 words
A method of claim 7 wherein the pilic component of the vaccine composition is derived from pili of E. coli 987-5 (ATCC 31346) or E. coli 74-5280 (ATCC 31347).
Claim 12
Dependent Claim
20 words
A method of claim 6 wherein the colostrum is administered by suckling the newborn piglets to previously vaccinated post-partum sows.
Claim 13
Dependent Claim
18 words
A method of claim 6 wherein the colostrum is drawn from post-partum sows and fed to newborn piglets.
Claim 14
Dependent Claim
52 words
A vaccine of claim 1 comprising pili derived from more than one member of the second group of strains wherein each of said members of said second group are capable of producing antibodies which will cause the cells of at least one member of said first group to agglutinate in their presence.
References Cited (Backward Citations)
US3127318A
Cited
US3975517A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-02 | 1984-06-02 | 1984-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-02 | 1988-06-02 | 1988-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-02 | 1992-06-02 | 1992-12-02 | $7700.00 | Window Closed / Lapsed |