EP0048422A2
Expired / Lapsed
EP
⏱️ 0.0 years remaining
Pili of pseudomonas aeruginosa and utilization of same as vaccines against infectionary p.aeruginosa
Assignee: Bactex Inc
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Filing: 1981-09-14
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Granted: —
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Expires: 2001-09-14
Abstract
Abstract There is provided a vaccine material capable of providing a substantial level of protection against infection by organisms of Pseudomonas aeruginosa. The protecting means comprises pili of the infecting organism. The protection is given either by administering the pili directly to the subject to be protected or by the passive administration of immune serum from another subject to whom P. aeruginosa pili have been previously administered. The material, or its immune serum, is effective in protecting burned subjects against P. aeruginosa infection.
Inventors
- 👤 Charles C. Brinton
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-11-09 03:11
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/195; C07K14/21; C07K14/212; C07K16/00; C07K16/12; C07K16/1203; C07K16/1214; C07K16/1217; C07K16/1228; C07K16/1232; A; A61; A61K; A61K38/00; A61K39/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
30 words
A material derived from pili-of P. aeruginosa which is substantially free of cells or cell debris which shows strong cross-reactivity against sera containing antibodies against pili derived from P. aeruginosa.
Claim 2
Dependent Claim
30 words
A material derived from pili-of P. aeruginosa which is substantially free of cells or cell debris which shows strong cross-reactivity against sera containing antibodies against pili derived from P. aeruginosa.
Claim 3
Dependent Claim
63 words
A material of Claim 1 comprising pili derived from at least one member of a second group of strains piliated P. aeruginosa organisms wherein cells of organisms of said first group react with serum containing antibodies against pili from said second group, said first group consisting of strains which may be the same as or different from the strains of said second group.
Claim 4
Dependent Claim
45 words
A material of Claim 2 comprising pili derived from more than one member of the second group of strains wherein each of said members of said second group are capable of producing antibodies which will react with at least one member of said first group.
Claim 5
Dependent Claim
19 words
A material of Claim 2 wherein a strain of the second group is P. aeruginosa 577 B (ATCC 31706).
Claim 6
Dependent Claim
47 words
A vaccine composition capable of raising the antibody level of a vertebrate subject to a level sufficient to provide protection against infection caused by a member of a first group of strains of piliated P. aeruginosa comprising a material of Claim 1 and a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
102 words
A vaccine composition capable of raising the antibody level of a vertebrate subject to a level sufficient to provide protection against infection caused by a member of a first group of strains of piliated P. aeruginosa comprising a) pili derivedfrom at least one member of a second group of strains of piliated P. aeruginosa organisms wherein cells of organisms of said first group are agglutinable by serum containing antibodies against pili from said second group, said first group consisting of strains which may be the same as or different from the strains of said second group, and b) a pharmaceutically acceptable carrier.
Claim 8
Dependent Claim
102 words
A vaccine composition capable of raising the antibody level of a vertebrate subject to a level sufficient to provide protection against infection caused by a member of a first group of strains of piliated P. aeruginosa comprising a) pili derivedfrom at least one member of a second group of strains of piliated P. aeruginosa organisms wherein cells of organisms of said first group are agglutinable by serum containing antibodies against pili from said second group, said first group consisting of strains which may be the same as or different from the strains of said second group, and b) a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
20 words
A composition of Claim 6 comprising 1-10 mg of pili of the second group per 10 ml of injectable vechile.
Claim 10
Dependent Claim
45 words
A composition of Claim 6 wherein the pilic component of the vaccine composition is derived from at least one member of the group of pili of P. aeruginosa 577 B (ATCC 31709), 1244 (ATCC 31710), 686 (ATCC 31711), 653A (ATCC 31707), or T2A (ATCC 31708).
Claim 11
Dependent Claim
60 words
Species homologous serum compositions comprising antibodies to P. aeruginosa produced by providing pili substantially free of cell material or cell debris, derived from P. aeruginosa into a living system of a predetermined species, permitting said system to generate antibodies to said pili, removing blood fluids from said system and separating the serum components containing said antibodies from said blood fluids.
Claim 12
Dependent Claim
60 words
Species homologous serum compositions comprising antibodies to P. aeruginosa produced by providing pili substantially free of cell material or cell debris, derived from P. aeruginosa into a living system of a predetermined species, permitting said system to generate antibodies to said pili, removing blood fluids from said system and separating the serum components containing said antibodies from said blood fluids.
Claim 13
Dependent Claim
27 words
A vaccine composition of Claim 2 wherein the strains of the said first group are the same as or junior to the strains of said second group.
References Cited (Backward Citations)
No citation records indexed.
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