US4585559A — Insoluble chelating compositions

Claim 1

Independent Claim 90 words

A method for inhibiting microbial growth in a liquid nutrient medium containing Fe 3+ by lowering the Fe 3+ content thereof to less than 0.1μM characterized in that said medium is contacted with an insoluble siderophoric composition and thereafter said siderophoric composition loaded with Fe 3+ is separated from said medium, said insoluble siderophoric composition comprising: (1) one or more organic siderophoric compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said organic siderophoric compounds possessing one or more coordinating sites capable of chelating Fe 3+ .

Claim 2

Independent Claim 90 words

A method for inhibiting microbial growth in a liquid nutrient medium containing Fe 3+ by lowering the Fe 3+ content thereof to less than 0.1μM characterized in that said medium is contacted with an insoluble siderophoric composition and thereafter said siderophoric composition loaded with Fe 3+ is separated from said medium, said insoluble siderophoric composition comprising: (1) one or more organic siderophoric compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said organic siderophoric compounds possessing one or more coordinating sites capable of chelating Fe 3+ .

Claim 3

Dependent Claim 65 words

A method as defined in claim 1, wherein said coordinating sites are provided by one or more members of the class consisting of (a) a N-substituted hydroxamate group of formula ##STR49## (b) a phenolate group of formula ##STR50## X being an atom of O or N--, and (c) a catecholate group of formula ##STR51## X' being an atom of O or N-and m being 1.

Claim 4

Independent Claim 103 words

A method for inhibiting microbial growth in a liquid nutrient medium containing Fe 3+ by lowering the Fe 3+ content thereof to less then 0.1μM characterized in that said medium is contacted with an insoluble siderophoric composition and thereafter said siderophoric composition loaded with Fe 3+ is separated from said medium, said insoluble siderophoric composition comprising (1) one or more organic siderophoric compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said organic siderophoric compounds possessing one or more coordinating sites capable of chelating Fe 3+ , said organic siderophoric compounds being selected from the class consisting of microbial siderophores.

Claim 5

Independent Claim 103 words

A method for inhibiting microbial growth in a liquid nutrient medium containing Fe 3+ by lowering the Fe 3+ content thereof to less then 0.1μM characterized in that said medium is contacted with an insoluble siderophoric composition and thereafter said siderophoric composition loaded with Fe 3+ is separated from said medium, said insoluble siderophoric composition comprising (1) one or more organic siderophoric compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said organic siderophoric compounds possessing one or more coordinating sites capable of chelating Fe 3+ , said organic siderophoric compounds being selected from the class consisting of microbial siderophores.

Claim 6

Dependent Claim 20 words

A method as defined in claim 3, wherein said microbial siderophores have a molecular weight of less then 2500 daltons.

Claim 7

Dependent Claim 66 words

A method as defined in claim 4, wherein said coordinating sites are provided by one or more members of the class consisting of (a) a N-substituted hydroxamate group of formula ##STR52## (b) a phenolate group of formula ##STR53## X being an atom of O or N--, and (c) a catecholate group of formula ##STR54## X' being an atom of O or N-- and m being 1.

Claim 8

Dependent Claim 23 words

A method as defined in claim 3, wherein said microbial siderophores have a molecular weight in the range of 500 to 2500 daltons.

Claim 9

Dependent Claim 23 words

A method as defined in claim 6, wherein said coordinating sites are provided by one or more N-substituted hydroxamate groups of formula ##STR55##

Claim 10

Dependent Claim 22 words

A method as defined in claim 6, wherein said coordinating sites are provided by one or more catecholate groups of formula ##STR56##

Claim 11

Dependent Claim 66 words

A method as defined in claim 6, wherein said coordinating sites are provided by one or more members of the class consisting of (a) a N-substituted hydroxamate group of formula ##STR57## (b) a phenolate group of formula ##STR58## X being an atom of O or N--, and (c) a catecholate group of formula ##STR59## X' being an atom of O or N-- and m being 1.

Claim 12

Dependent Claim 66 words

A method as defined in claim 3, wherein said coordinating sites are provided by one or more members of the class consisting of (a) a N-substituted hydroxamate group of formula ##STR60## (b) a phenolate group of formula ##STR61## X being an atom of O or N--, and (c) a catecholate group of formula ##STR62## X' being an atom of O or N-- and m being 1.

Claim 13

Dependent Claim 20 words

A method as defined in claim 3, wherein said organic siderophoric compounds are selected from the class consisting of desferrioxamines.

Claim 14

Dependent Claim 19 words

A method as defined in claim 3, wherein the organic siderophoric compound covalently fixed to the carrier is enterobactin.

Claim 15

Independent Claim 112 words

A method for inhibiting microbial growth in a liquid nutrient medium containing Fe 3+ by lowering the Fe 3+ content thereof to less then 0.1μM characterized in that said medium is contacted with an insoluble siderophoric composition and thereafter said siderophoric composition loaded with Fe 3+ is separated from said medium, said insoluble siderophoric composition comprising (1) one or more catechol compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said catechol compounds being covalently fixed to the surface of said carrier at the benzene ring thereof, said catechol compounds being selected from the group consisting of catechol substituted on the benzene ring by one or two electrophilic substituents.

Claim 16

Independent Claim 112 words

A method for inhibiting microbial growth in a liquid nutrient medium containing Fe 3+ by lowering the Fe 3+ content thereof to less then 0.1μM characterized in that said medium is contacted with an insoluble siderophoric composition and thereafter said siderophoric composition loaded with Fe 3+ is separated from said medium, said insoluble siderophoric composition comprising (1) one or more catechol compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said catechol compounds being covalently fixed to the surface of said carrier at the benzene ring thereof, said catechol compounds being selected from the group consisting of catechol substituted on the benzene ring by one or two electrophilic substituents.

Claim 17

Dependent Claim 19 words

A method as defined in claim 13, wherein the catechol compound covalently fixed to the carrier is unsubstituted catechol.

Claim 18

Dependent Claim 42 words

A method as defined in claim 13, wherein said catechol compounds are selected from the group consisting of catechol substituted on the benzene ring by one or two substituents selected from the class consisting of halogen atoms, NO and NO 2 .

Claim 19

Dependent Claim 30 words

A method as defined in claim 13, wherein said catechol compounds are selected from the group consisting of catechol substituted on the benzene ring by one or two halogen atoms.

Claim 20

Dependent Claim 17 words

A method as defined in claim 16, wherein said halogen atoms are selected from chlorine and bromine.

Claim 21

Dependent Claim 34 words

A method as defined in claim 13, wherein said catechol compound is selected from the group consisting of catechol monosubstituted on the benzene ring by a substituent selected from NO and NO 2 .

Claim 22

Independent Claim 149 words

A method for removing Fe 3+ , Th 4+ , UO 2 2+ or mixtures thereof from solution characterized in that the solution is contacted with an insoluble composition comprising a member selected from the class consisting of (A) an insoluble composition comprising (1) one or more organic chelating compounds, covalently fixed to the surface of (2) a suitable insoluble carrier, said organic chelating compounds possessing one or more coordinating sites, said organic chelating compounds being selected from the class consisting of microbial siderophores and (B) an insoluble composition comprising (1) one or more catechol compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said catechol compounds being covalently fixed to the surface of said carrier at the benzene ring thereof, said catechol compounds being selected from the group consisting of unsubstituted catechol and catechol substituted on the benzene ring by one or two electrophilic substituents.

Claim 23

Independent Claim 149 words

A method for removing Fe 3+ , Th 4+ , UO 2 2+ or mixtures thereof from solution characterized in that the solution is contacted with an insoluble composition comprising a member selected from the class consisting of (A) an insoluble composition comprising (1) one or more organic chelating compounds, covalently fixed to the surface of (2) a suitable insoluble carrier, said organic chelating compounds possessing one or more coordinating sites, said organic chelating compounds being selected from the class consisting of microbial siderophores and (B) an insoluble composition comprising (1) one or more catechol compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said catechol compounds being covalently fixed to the surface of said carrier at the benzene ring thereof, said catechol compounds being selected from the group consisting of unsubstituted catechol and catechol substituted on the benzene ring by one or two electrophilic substituents.

Claim 24

Independent Claim 71 words

A method for removing Fe 3+ , Th 4+ , UO 2 2+ or mixtures thereof from solution characterized in that the solution is contacted with an insoluble composition comprising (1) one or more organic chelating compounds, covalently fixed to the surface of (2) a suitable insoluble carrier, said organic chelating compounds possessing one or more coordinating sites, said organic chelating compounds being selected from the class consisting of microbial siderophores.

Claim 25

Independent Claim 71 words

A method for removing Fe 3+ , Th 4+ , UO 2 2+ or mixtures thereof from solution characterized in that the solution is contacted with an insoluble composition comprising (1) one or more organic chelating compounds, covalently fixed to the surface of (2) a suitable insoluble carrier, said organic chelating compounds possessing one or more coordinating sites, said organic chelating compounds being selected from the class consisting of microbial siderophores.

Claim 26

Dependent Claim 20 words

A method as defined in claim 20, wherein said microbial siderophores have a molecular weight of less than 2500 daltons.

Claim 27

Dependent Claim 66 words

A method as defined in claim 21, wherein said coordinating sites are provided by one or more members of the class consisting of (a) a N-substituted hydroxamate group of formula ##STR63## (b) a phenolate group of formula ##STR64## X being an atom of O or N--, and (c) a catecholate group of formula ##STR65## X' being an atom of O or N-- and m being 1.

Claim 28

Dependent Claim 23 words

A method as defined in claim 20, wherein said microbial siderophores have a molecular weight in the range of 500 to 2500 daltons.

Claim 29

Dependent Claim 23 words

A method as defined in claim 23, wherein said coordinating sites are provided by one or more N-substituted hydroxamate groups of formula ##STR66##

Claim 30

Dependent Claim 22 words

A method as defined in claim 23, wherein said coordinating sites are provided by one or more catecholate groups of formula ##STR67##

Claim 31

Dependent Claim 66 words

A method as defined in claim 23, wherein said coordinating sites are provided by one or more members of the class consisting of (a) a N-substituted hydroxamate group of formula ##STR68## (b) a phenolate group of formula ##STR69## X being an atom of O or N--, and (c) a catecholate group of formula ##STR70## X' being an atom of O or N-- and m being 1.

Claim 32

Dependent Claim 66 words

A method as defined in claim 20, wherein said coordinating sites are provided by one or more members of the class consisting of (a) a N-substituted hydroxamate group of formula ##STR71## (b) a phenolate group of formula ##STR72## X being an atom of O or N--, and (c) a catecholate group of formula ##STR73## X' being an atom of O or N-- and m being 1.

Claim 33

Dependent Claim 20 words

A method as defined in claim 20, wherein said organic chelating compounds are selected from the class consisting of desferrioxamines.

Claim 34

Dependent Claim 19 words

A method as defined in claim 20, wherein the organic chelating compound covalently fixed to the carrier is enterobactin.

Claim 35

Independent Claim 89 words

A method for removing Fe 3+ , Th 4+ , UO 2 2+ or mixtures thereof from solution characterized in that the solution is contacted with an insoluble composition comprising: (1) one or more catechol compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said catechol compounds being covalently fixed to the surface of said carrier at the benzene ring thereof, said catechol compounds being selected from the group consisting of unsubstituted catechol and catechol substituted on the benzene ring by one or two electrophilic substituents.

Claim 36

Independent Claim 89 words

A method for removing Fe 3+ , Th 4+ , UO 2 2+ or mixtures thereof from solution characterized in that the solution is contacted with an insoluble composition comprising: (1) one or more catechol compounds covalently fixed to the surface of (2) a suitable insoluble carrier, said catechol compounds being covalently fixed to the surface of said carrier at the benzene ring thereof, said catechol compounds being selected from the group consisting of unsubstituted catechol and catechol substituted on the benzene ring by one or two electrophilic substituents.

Claim 37

Dependent Claim 18 words

A method as defined in claim 30, wherein the catechol compound fixed to the carrier is unsubstituted catechol.

Claim 38

Dependent Claim 42 words

A method as defined in claim 30, wherein said catechol compounds are selected from the group consisting of catechol substituted on the benzene ring by one or two substituents selected from the class consisting of halogen atoms, NO and NO 2 .

Claim 39

Dependent Claim 30 words

A method as defined in claim 30, wherein said catechol compounds are selected from the group consisting of catechol substituted on the benzene ring by one or two halogen atoms.

Claim 40

Dependent Claim 17 words

A method as defined in claim 33, wherein said halogen atoms are selected from chlorine and bromine.

Claim 41

Dependent Claim 34 words

A method as defined in claim 30, wherein said catechol compound is selected from the group consisting of catechol monosubstituted on the benzene ring by a substituent selected from NO and NO 2 .

Claim 42

Dependent Claim 35 words

A method as defined in claim 30, wherein said catechol compounds convalently fixed to the carrier are selected from the group consisting of catechol substituted on the benzene ring by one or two electrophilic substituents.

Claim 43

Dependent Claim 27 words

A method as defined in claim 36, wherein said electrophilic substituents are selected from the group consisting of halogen atoms, NO, NO 2 , COOH and ##STR74##

Claim 44

Independent Claim 50 words

A method for removing Th 4+ from solution comprising the step of contacting a solution which contains Th 4+ with an insoluble composition comprising catechol convalently fixed to the surface of a suitable insoluble carrier, said catechol being fixed at the benzene ring thereof to the surface of said carrier.

Claim 45

Independent Claim 50 words

A method for removing Th 4+ from solution comprising the step of contacting a solution which contains Th 4+ with an insoluble composition comprising catechol convalently fixed to the surface of a suitable insoluble carrier, said catechol being fixed at the benzene ring thereof to the surface of said carrier.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1989-04-28	1989-10-28	1990-04-29	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1993-04-28	1993-10-28	1994-04-29	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1997-04-28	1997-10-28	1998-04-29	$7700.00	Window Closed / Lapsed

Insoluble chelating compositions

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