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US4575495A
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Synthetic antigenic peptide derived from Hepatitis B surface antigen
Assignee: New York Blood Center
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Filing: 1984-07-17
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Granted: 1986-03-11
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Expires: 2004-07-17
Abstract
Abstract There is disclosed a new synthetic peptide which evokes an immunological response. The synthetic peptide, moreover, interacts with antibodies to Hepatitis B surface antigen (HBsAG). Thus, the synthetic peptide is useful as an immunizing agent in a vaccine as an active component thereof where it serves to produce antibodies in vivo which are protective against Hepatitis B virus. The synthetic peptide of the invention comprises the following sequence of amino acids: Arg Trp Met Met Leu Arg Arg(I) and preferably has the following sequence: Gly Tyr Arg Trp Met Met Leu Arg Arg Phe Gly (II).
Inventors
- 👤 John Vnek
- 👤 Alfred M. Prince
- 👤 Hafeez Ikram
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 22:13
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/005; A; A61; A61K; A61K39/00; C12; C12N; C12N2730/00; C12N2730/00011; C12N2730/10011; C12N2730/10111; C12N2730/10122; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/22; Y10S930/223
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
28 words
A synthetic peptide consisting essentially of the following sequence of amino acids Arg Trp Met Met Leu Arg Arg (I) wherein said peptide is disposed on a carrier.
Claim 2
Dependent Claim
28 words
A synthetic peptide consisting essentially of the following sequence of amino acids Arg Trp Met Met Leu Arg Arg (I) wherein said peptide is disposed on a carrier.
Claim 3
Dependent Claim
15 words
A synthetic peptide according to claim 1, wherein said carrier is a physiologically acceptable carrier.
Claim 4
Dependent Claim
13 words
A synthetic peptide according to claim 2, wherein said carrier comprises tetanus toxoid.
Claim 5
Dependent Claim
13 words
A synthetic peptide according to claim 1, wherein said carrier comprises polyethylene glycol.
References Cited (Backward Citations)
US4428941A
Cited
US4493796A
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Cited
US4499080A
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US4496521A
Cited
US4493795A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-03-10 | 1989-09-09 | 1990-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-03-10 | 1993-09-09 | 1994-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-03-10 | 1997-09-09 | 1998-03-11 | $7700.00 | Window Closed / Lapsed |