US4493796A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Didemnins A, B, C, and derivatives thereof, as antiviral agents
Assignee: University of Illinois at Urbana-Champaign
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Filing: 1984-03-13
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Granted: 1985-01-15
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Expires: 2004-03-13
Abstract
Abstract Novel antibiotics didemnins A, B, C, D, and E (didemnins), are obtained from a marine organism. These antibiotics, and derivatives thereof, are active against a variety of DNA and RNA viruses; thus, they can be used in various environments to control or eradicate these viruses.
Inventors
- 👤 Kenneth L. Rinehart, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 06:37
CPC Classifications
C; C07; C07K; C07K11/00; Y; Y10; Y10S; Y10S530/00; Y10S530/855; Y10S930/00; Y10S930/01; Y10S930/19; Y10S930/27
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
119 words
A didemnin of the Formula I wherein R is (a) hydrogen, (b) --COCH 3 , (c) a side chain of Formula II, ##STR13## (d) a side chain of Formula III, ##STR14## (e) CH 3 CHOHC(O)--, (f) a side chain of Formula IV, ##STR15## (g) a side chain of Formula V, ##STR16## (h) CH 3 CH 2 (CO)--, (i) (CH 3 ) 2 CHCH 2 CH(NH 2 )C(O)--, or (j) a side chain of the formula VI, ##STR17## wherein R 1 is hydrogen; or R and R 1 taken together form methylene (--CH 2 --); wherein R 2 is (a) hydrogen, or (b) --COCH 3 ; and wherein X is (a) ═O, or (b) H, --OH, or an acylate thereof.
Claim 2
Dependent Claim
119 words
A didemnin of the Formula I wherein R is (a) hydrogen, (b) --COCH 3 , (c) a side chain of Formula II, ##STR13## (d) a side chain of Formula III, ##STR14## (e) CH 3 CHOHC(O)--, (f) a side chain of Formula IV, ##STR15## (g) a side chain of Formula V, ##STR16## (h) CH 3 CH 2 (CO)--, (i) (CH 3 ) 2 CHCH 2 CH(NH 2 )C(O)--, or (j) a side chain of the formula VI, ##STR17## wherein R 1 is hydrogen; or R and R 1 taken together form methylene (--CH 2 --); wherein R 2 is (a) hydrogen, or (b) --COCH 3 ; and wherein X is (a) ═O, or (b) H, --OH, or an acylate thereof.
Claim 3
Dependent Claim
28 words
Antibiotic didemnin A, a compound of claim 1, wherein R, R 1 , and R 2 are hydrogen and X is ═O, or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
35 words
Antibiotic didemnin B, a compound of claim 1, wherein R 1 and R 2 are hydrogen, R is a Formula II substituent --COCH 3 , and X is ═O, or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
31 words
Antibiotic didemnin C, a compound of claim 1, wherein R is CH 3 CHOHC(O), R 1 and R 2 are hydrogen, and X is ═O, or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
30 words
N-acetyldidemnin A, a compound of claim 1, wherein R is --COCH 3 , R 1 and R 2 are hydrogen, and X is ═O; or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
30 words
Diacetyldidemnin A, a compound of claim 1, wherein R and R 2 are --COCH 3 , R 1 is hydrogen, and X is ═O; or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
28 words
Dihydrodidemnin A, a compound of claim 1 wherein R, R 1 , and R 2 are hydrogen and X is H, OH; or a pharmaceutically acceptable salt thereof.
Claim 9
Dependent Claim
25 words
Methylene didemnin A, a compound of claim 1, wherein R and R 1 form --CH 2 --, R 2 is hydrogen, and X is ═O.
Claim 10
Dependent Claim
34 words
Diacetyldidemnin B, a compound of claim 1, wherein R is a Formula III substituent, R 1 is hydrogen, R 2 is --COCH 3 , and X is ═O; or a pharmaceutically acceptable salt thereof.
Claim 11
Dependent Claim
31 words
Didemnin D, a compound of claim 1, wherein R is a Formula IV substituent, R 1 and R 2 are hydrogen, and X is ═O; or a pharmaceutically acceptable salt thereof.
Claim 12
Dependent Claim
31 words
Didemnin E, a compound of claim 1, wherein R is a Formula V substituent, R 1 and R 2 are hydrogen, and X is ═O; or a pharmaceutically acceptable salt thereof.
Claim 13
Dependent Claim
32 words
N-Propionyl-Didemnin A, a compound of claim 1, wherein R is CH 3 CH 2 C(O)--, R 1 and R 2 are hydrogen, and X is ═O; or a pharmaceutically acceptable salt thereof.
Claim 14
Dependent Claim
37 words
N-(L)-Leucyl Didemnin A, a compound of claim 1, wherein R is (CH 3 ) 2 CHCH 2 CH(NH 2 )(Co)--, R 1 and R 2 are hydrogen and X is ═O; or a pharmaceutically acceptable salt thereof.
Claim 15
Dependent Claim
31 words
N-(L)-Prolyl-Didemnin A, a compound of claim 1, wherein R is a formula VI substituent, R 1 and R 2 are hydrogen, and X is ═O, or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-01-15 | 1988-07-16 | 1989-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-01-15 | 1992-07-16 | 1993-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-01-15 | 1996-07-16 | 1997-01-15 | $7700.00 | Window Closed / Lapsed |