US4499081A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Peptide compounds
Assignee: GE Healthcare AS
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Filing: 1983-11-28
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Granted: 1985-02-12
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Expires: 2003-11-28
Abstract
Abstract The invention provides compounds of the general formula: ##STR1## (in which R 1 is the residue of glycine or D-alanine, and all other amino-acid residues are in the L-form, X 1 and X 2 , which may be the same or different, are OH or NH 2 and n is 0 or 1) and their physiologically acceptable salts. The compounds of the invention are capable of inhibiting the myelopoietic system of humans and animals, thereby protecting said system against attack by cytotoxic drugs.
Inventors
- 👤 Ole D. Laerum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 12:02
CPC Classifications
C; C07; C07K; C07K7/00; C07K7/04; C07K7/06; C07K7/067; A; A61; A61P; A61P35/00; A61P35/02; A61P7/00; A61K; A61K38/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
55 words
A compound of the formula: ##STR5## (in which R 1 is the residue of glycine or D-alanine, and all other amino-acid residues are in the L-form, X 1 and X 2 , which may be the same or different, are OH or NH 2 and n is 0 or 1) and their physiologically acceptable salts.
Claim 2
Dependent Claim
55 words
A compound of the formula: ##STR5## (in which R 1 is the residue of glycine or D-alanine, and all other amino-acid residues are in the L-form, X 1 and X 2 , which may be the same or different, are OH or NH 2 and n is 0 or 1) and their physiologically acceptable salts.
Claim 3
Dependent Claim
11 words
A compound which is L-pyroGlutamyl-L-glutaminyl-L-aspartyl-L-cysteinyl-L-lysine; L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-glycyl-L-lysine; L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-L-lysine; L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-D-alanyl-L-lysine; or L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-L-lysine amide.
Claim 4
Dependent Claim
11 words
A compound which is L-pyroGlutamyl-L-glutaminyl-L-aspartyl-L-cysteinyl-L-lysine; L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-glycyl-L-lysine; L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-L-lysine; L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-D-alanyl-L-lysine; or L-pyroGlutamyl-L-glutamyl-L-aspartyl-L-cysteinyl-L-lysine amide.
Claim 5
Dependent Claim
10 words
A compound as claimed in claim 1 in crystalline form.
Claim 6
Dependent Claim
10 words
A compound as claimed in claim 2 in crystalline form.
Claim 7
Dependent Claim
78 words
A compound of the formula II: ##STR6## wherein R 1 is the residue of glycine or D-alanine, and all other amino acid residues are in the L-form, R 2 and R 6 are amine protecting groups or hydrogen atoms, R 3 , R 4 and R 7 are NH 2 , protected amino or carboxyl protecting groups or OH, R 5 is a thiol protecting group, and n is zero or one, and the physiologically acceptable salts thereof.
Claim 8
Dependent Claim
78 words
A compound of the formula II: ##STR6## wherein R 1 is the residue of glycine or D-alanine, and all other amino acid residues are in the L-form, R 2 and R 6 are amine protecting groups or hydrogen atoms, R 3 , R 4 and R 7 are NH 2 , protected amino or carboxyl protecting groups or OH, R 5 is a thiol protecting group, and n is zero or one, and the physiologically acceptable salts thereof.
Claim 9
Dependent Claim
19 words
A pharmaceutical composition comprising a compound as claimed in claim 1 in conjunction with a pharmaceutical carrier or excipient.
Claim 10
Dependent Claim
31 words
A method of inhibiting the myelopoietic system of a human or animal subject in which an effective dose of a compound as claimed in claim 1 is administered to said subject.
References Cited (Backward Citations)
US3792032A
Cited
US3928306A
Cited
US4235772A
Cited
FR2465486A1
Cited
US4412988A
Cited
US4411890A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-02-12 | 1988-08-13 | 1989-02-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-02-12 | 1992-08-13 | 1993-02-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-02-12 | 1996-08-13 | 1997-02-12 | $7700.00 | Window Closed / Lapsed |